PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: ataxia telangiectasia-mutated (ATM) signaling pathway
Accession: PW:0001361
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Definition: The ataxia telangiectasia-mutated (ATM) serine/threonine kinase mediated signaling plays a major role in the response to DNA double strand breaks (DSB). Following lesion sensing by the MRN complex, ATM gets activated. Active ATM phosphorylates itself and targets resulting in triggering of DNA repair, cell cycle checkpoint and signaling pathways. While ATM signaling is best documented for its role in DSB responses, evidence accumulates that it functions in a range of other, DNA damage unrelated, responses.
Synonyms: exact_synonym: ATM signaling pathway
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Atm
ATM serine/threonine kinase
ISO
RGD
PMID:23532176 PMID:21533982
RGD:8661225 , RGD:8661232
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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Baz1b
bromodomain adjacent to zinc finger domain, 1B
ISO
RGD
PMID:24002223
RGD:8661242
NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426
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Brca1
BRCA1, DNA repair associated
ISO
RGD
PMID:24326623
RGD:8661237
NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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Brcc3
BRCA1/BRCA2-containing complex subunit 3
ISO
RGD
PMID:24002223
RGD:8661242
NCBI chr 9:1,986,942...1,989,484
Ensembl chr 9:1,986,575...1,991,080
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Eya1
EYA transcriptional coactivator and phosphatase 1
ISO
RGD
PMID:24002223
RGD:8661242
NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483
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Eya3
EYA transcriptional coactivator and phosphatase 3
ISO
RGD
PMID:24002223
RGD:8661242
NCBI chr 5:144,806,523...144,934,522
Ensembl chr 5:144,806,577...144,934,518
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H2ax
H2A.X variant histone
ISO
RGD
PMID:21533982 PMID:24002223
RGD:8661232 , RGD:8661242
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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Kat5
lysine acetyltransferase 5
ISO
RGD
PMID:23532176 PMID:21533982
RGD:8661225 , RGD:8661232
NCBI chr 1:202,895,751...202,903,178
Ensembl chr 1:202,895,751...202,903,458
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Kdm4a
lysine demethylase 4A
ISO
RGD
PMID:24326623 PMID:24002223
RGD:8661237 , RGD:8661242
NCBI chr 5:131,672,754...131,719,534
Ensembl chr 5:131,672,754...131,719,501
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L3mbtl1
L3MBTL histone methyl-lysine binding protein 1
ISO
RGD
PMID:24326623 PMID:24002223
RGD:8661237 , RGD:8661242
NCBI chr 3:151,597,903...151,633,657
Ensembl chr 3:151,602,980...151,631,233
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Mdc1
mediator of DNA damage checkpoint 1
ISO
RGD
PMID:21533982 PMID:24002223
RGD:8661232 , RGD:8661242
NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240
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Mre11
MRE11 homolog, double strand break repair nuclease
ISO
RGD
PMID:21533982
RGD:8661232
NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
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Nbn
nibrin
ISO
RGD
PMID:21533982
RGD:8661232
NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
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Otub1
OTU deubiquitinase, ubiquitin aldehyde binding 1
ISO
RGD
PMID:24002223
RGD:8661242
NCBI chr 1:204,387,215...204,395,495
Ensembl chr 1:204,387,215...204,395,483
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Pias1
protein inhibitor of activated STAT, 1
ISO
RGD
PMID:24002223
RGD:8661242
NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905
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Pias4
protein inhibitor of activated STAT, 4
ISO
RGD
PMID:24002223
RGD:8661242
NCBI chr 7:8,546,312...8,559,838
Ensembl chr 7:8,546,312...8,559,808
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Ppm1d
protein phosphatase, Mg2+/Mn2+ dependent, 1D
ISO
RGD
PMID:21533982 PMID:24002223
RGD:8661232 , RGD:8661242
NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607
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Ppp2ca
protein phosphatase 2 catalytic subunit alpha
ISO
RGD
PMID:21533982 PMID:24002223
RGD:8661232 , RGD:8661242
NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
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Ppp4c
protein phosphatase 4, catalytic subunit
ISO
RGD
PMID:24002223
RGD:8661242
NCBI chr 1:181,392,899...181,399,703
Ensembl chr 1:181,392,923...181,399,659
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Ppp5c
protein phosphatase 5, catalytic subunit
ISO
RGD
PMID:21533982
RGD:8661232
NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456
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Ppp6c
protein phosphatase 6, catalytic subunit
ISO
RGD
PMID:24002223
RGD:8661242
NCBI chr 3:22,929,816...22,962,123
Ensembl chr 3:22,931,577...22,962,113
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Psmd14
proteasome 26S subunit, non-ATPase 14
ISO
RGD
PMID:24002223
RGD:8661242
NCBI chr 3:46,254,338...46,347,076
Ensembl chr 3:46,254,330...46,347,076
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Pwwp3a
PWWP domain containing 3A, DNA repair factor
ISO
RGD
PMID:24326623
RGD:8661237
NCBI chr 7:9,465,180...9,482,053
Ensembl chr 7:9,465,195...9,481,966
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Rad50
RAD50 double strand break repair protein
ISO
RGD
PMID:21533982
RGD:8661232
NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396
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Rbbp8
RB binding protein 8, endonuclease
ISO
RGD
PMID:24326623
RGD:8661237
NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846
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Rif1
replication timing regulatory factor 1
ISO
RGD
PMID:24326623
RGD:8661237
NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617
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Rnf168
ring finger protein 168
ISO
RGD
PMID:21533982 PMID:24326623
RGD:8661232 , RGD:8661237
NCBI chr11:68,486,313...68,508,296
Ensembl chr11:68,486,321...68,508,277
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Rnf20
ring finger protein 20
ISO
RGD
PMID:23532176
RGD:8661225
NCBI chr 5:63,976,063...64,001,754
Ensembl chr 5:63,976,045...64,001,754
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Rnf4
ring finger protein 4
ISO
RGD
PMID:24002223
RGD:8661242
NCBI chr14:76,401,292...76,423,270
Ensembl chr14:76,401,299...76,422,566
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Rnf40
ring finger protein 40
ISO
RGD
PMID:23532176
RGD:8661225
NCBI chr 1:182,202,475...182,217,899
Ensembl chr 1:182,202,600...182,217,241
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Rnf8
ring finger protein 8
ISO
RGD
PMID:21533982 PMID:24326623
RGD:8661232 , RGD:8661237
NCBI chr20:7,682,258...7,710,448
Ensembl chr20:7,682,322...7,708,491
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Tp53bp1
tumor protein p53 binding protein 1
ISO
RGD
PMID:24326623
RGD:8661237
NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
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Trip12
thyroid hormone receptor interactor 12
ISO
RGD
PMID:24002223
RGD:8661242
NCBI chr 9:85,916,691...86,043,312
Ensembl chr 9:85,916,691...86,051,403
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Ube2n
ubiquitin-conjugating enzyme E2N
ISO
RGD
PMID:21533982 PMID:24326623
RGD:8661232 , RGD:8661237
NCBI chr 7:30,154,330...30,184,373
Ensembl chr 7:30,154,616...30,184,355
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Ubr5
ubiquitin protein ligase E3 component n-recognin 5
ISO
RGD
PMID:24002223
RGD:8661242
NCBI chr 7:69,115,216...69,224,843
Ensembl chr 7:69,116,761...69,224,903
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Usp16
ubiquitin specific peptidase 16
ISO
RGD
PMID:24002223
RGD:8661242
NCBI chr11:26,681,359...26,711,313
Ensembl chr11:26,681,414...26,710,539
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Usp3
ubiquitin specific peptidase 3
ISO
RGD
PMID:24002223
RGD:8661242
NCBI chr 8:67,078,249...67,154,109
Ensembl chr 8:67,079,927...67,154,111
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Usp44
ubiquitin specific peptidase 44
ISO
RGD
PMID:24002223
RGD:8661242
NCBI chr 7:28,364,169...28,412,039
Ensembl chr 7:28,364,033...28,410,053
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Vcp
valosin-containing protein
ISO
RGD
PMID:24326623 PMID:24002223
RGD:8661237 , RGD:8661242
NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571
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