Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:ataxia telangiectasia-mutated (ATM) signaling pathway
go back to main search page
Accession:PW:0001361 term browser browse the term
Definition:The ataxia telangiectasia-mutated (ATM) serine/threonine kinase mediated signaling plays a major role in the response to DNA double strand breaks (DSB). Following lesion sensing by the MRN complex, ATM gets activated. Active ATM phosphorylates itself and targets resulting in triggering of DNA repair, cell cycle checkpoint and signaling pathways. While ATM signaling is best documented for its role in DSB responses, evidence accumulates that it functions in a range of other, DNA damage unrelated, responses.
Synonyms:exact_synonym: ATM signaling pathway

View Interactive Diagram



show annotations for term's descendants           Sort by:
ataxia telangiectasia-mutated (ATM) signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase ISO RGD PMID:23532176 PMID:21533982 RGD:8661225, RGD:8661232 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Baz1b bromodomain adjacent to zinc finger domain, 1B ISO RGD PMID:24002223 RGD:8661242 NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426
JBrowse link
G Brca1 BRCA1, DNA repair associated ISO RGD PMID:24326623 RGD:8661237 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Brcc3 BRCA1/BRCA2-containing complex subunit 3 ISO RGD PMID:24002223 RGD:8661242 NCBI chr 9:1,986,942...1,989,484
Ensembl chr 9:1,986,575...1,991,080
JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 ISO RGD PMID:24002223 RGD:8661242 NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483
JBrowse link
G Eya3 EYA transcriptional coactivator and phosphatase 3 ISO RGD PMID:24002223 RGD:8661242 NCBI chr 5:144,806,523...144,934,522
Ensembl chr 5:144,806,577...144,934,518
JBrowse link
G H2ax H2A.X variant histone ISO RGD PMID:21533982 PMID:24002223 RGD:8661232, RGD:8661242 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Kat5 lysine acetyltransferase 5 ISO RGD PMID:23532176 PMID:21533982 RGD:8661225, RGD:8661232 NCBI chr 1:202,895,751...202,903,178
Ensembl chr 1:202,895,751...202,903,458
JBrowse link
G Kdm4a lysine demethylase 4A ISO RGD PMID:24326623 PMID:24002223 RGD:8661237, RGD:8661242 NCBI chr 5:131,672,754...131,719,534
Ensembl chr 5:131,672,754...131,719,501
JBrowse link
G L3mbtl1 L3MBTL histone methyl-lysine binding protein 1 ISO RGD PMID:24326623 PMID:24002223 RGD:8661237, RGD:8661242 NCBI chr 3:151,597,903...151,633,657
Ensembl chr 3:151,602,980...151,631,233
JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 ISO RGD PMID:21533982 PMID:24002223 RGD:8661232, RGD:8661242 NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease ISO RGD PMID:21533982 RGD:8661232 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
JBrowse link
G Nbn nibrin ISO RGD PMID:21533982 RGD:8661232 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
JBrowse link
G Otub1 OTU deubiquitinase, ubiquitin aldehyde binding 1 ISO RGD PMID:24002223 RGD:8661242 NCBI chr 1:204,387,215...204,395,495
Ensembl chr 1:204,387,215...204,395,483
JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 ISO RGD PMID:24002223 RGD:8661242 NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905
JBrowse link
G Pias4 protein inhibitor of activated STAT, 4 ISO RGD PMID:24002223 RGD:8661242 NCBI chr 7:8,546,312...8,559,838
Ensembl chr 7:8,546,312...8,559,808
JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D ISO RGD PMID:21533982 PMID:24002223 RGD:8661232, RGD:8661242 NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha ISO RGD PMID:21533982 PMID:24002223 RGD:8661232, RGD:8661242 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
JBrowse link
G Ppp4c protein phosphatase 4, catalytic subunit ISO RGD PMID:24002223 RGD:8661242 NCBI chr 1:181,392,899...181,399,703
Ensembl chr 1:181,392,923...181,399,659
JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit ISO RGD PMID:21533982 RGD:8661232 NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456
JBrowse link
G Ppp6c protein phosphatase 6, catalytic subunit ISO RGD PMID:24002223 RGD:8661242 NCBI chr 3:22,929,816...22,962,123
Ensembl chr 3:22,931,577...22,962,113
JBrowse link
G Psmd14 proteasome 26S subunit, non-ATPase 14 ISO RGD PMID:24002223 RGD:8661242 NCBI chr 3:46,254,338...46,347,076
Ensembl chr 3:46,254,330...46,347,076
JBrowse link
G Pwwp3a PWWP domain containing 3A, DNA repair factor ISO RGD PMID:24326623 RGD:8661237 NCBI chr 7:9,465,180...9,482,053
Ensembl chr 7:9,465,195...9,481,966
JBrowse link
G Rad50 RAD50 double strand break repair protein ISO RGD PMID:21533982 RGD:8661232 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396
JBrowse link
G Rbbp8 RB binding protein 8, endonuclease ISO RGD PMID:24326623 RGD:8661237 NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846
JBrowse link
G Rif1 replication timing regulatory factor 1 ISO RGD PMID:24326623 RGD:8661237 NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617
JBrowse link
G Rnf168 ring finger protein 168 ISO RGD PMID:21533982 PMID:24326623 RGD:8661232, RGD:8661237 NCBI chr11:68,486,313...68,508,296
Ensembl chr11:68,486,321...68,508,277
JBrowse link
G Rnf20 ring finger protein 20 ISO RGD PMID:23532176 RGD:8661225 NCBI chr 5:63,976,063...64,001,754
Ensembl chr 5:63,976,045...64,001,754
JBrowse link
G Rnf4 ring finger protein 4 ISO RGD PMID:24002223 RGD:8661242 NCBI chr14:76,401,292...76,423,270
Ensembl chr14:76,401,299...76,422,566
JBrowse link
G Rnf40 ring finger protein 40 ISO RGD PMID:23532176 RGD:8661225 NCBI chr 1:182,202,475...182,217,899
Ensembl chr 1:182,202,600...182,217,241
JBrowse link
G Rnf8 ring finger protein 8 ISO RGD PMID:21533982 PMID:24326623 RGD:8661232, RGD:8661237 NCBI chr20:7,682,258...7,710,448
Ensembl chr20:7,682,322...7,708,491
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 ISO RGD PMID:24326623 RGD:8661237 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
JBrowse link
G Trip12 thyroid hormone receptor interactor 12 ISO RGD PMID:24002223 RGD:8661242 NCBI chr 9:85,916,691...86,043,312
Ensembl chr 9:85,916,691...86,051,403
JBrowse link
G Ube2n ubiquitin-conjugating enzyme E2N ISO RGD PMID:21533982 PMID:24326623 RGD:8661232, RGD:8661237 NCBI chr 7:30,154,330...30,184,373
Ensembl chr 7:30,154,616...30,184,355
JBrowse link
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 ISO RGD PMID:24002223 RGD:8661242 NCBI chr 7:69,115,216...69,224,843
Ensembl chr 7:69,116,761...69,224,903
JBrowse link
G Usp16 ubiquitin specific peptidase 16 ISO RGD PMID:24002223 RGD:8661242 NCBI chr11:26,681,359...26,711,313
Ensembl chr11:26,681,414...26,710,539
JBrowse link
G Usp3 ubiquitin specific peptidase 3 ISO RGD PMID:24002223 RGD:8661242 NCBI chr 8:67,078,249...67,154,109
Ensembl chr 8:67,079,927...67,154,111
JBrowse link
G Usp44 ubiquitin specific peptidase 44 ISO RGD PMID:24002223 RGD:8661242 NCBI chr 7:28,364,169...28,412,039
Ensembl chr 7:28,364,033...28,410,053
JBrowse link
G Vcp valosin-containing protein ISO RGD PMID:24326623 PMID:24002223 RGD:8661237, RGD:8661242 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3867
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1738
        DNA damage response pathway 405
          ataxia telangiectasia-mutated (ATM) signaling pathway 39
paths to the root