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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:folate cycle metabolic pathway
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Accession:PW:0001207 term browser browse the term
Definition:The folate cycle metabolic pathway sums up the uptake and transport of folates, the processing and interconversion reactions of folate compounds. The folate cycle and the folate mediate one-carbon transfer pathways are part of folate metabolism.
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folate cycle metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family member L1 ISO RGD PMID:22353665 RGD:7242562 NCBI chrNW_004955421:21,420,264...21,506,004
Ensembl chrNW_004955421:21,420,147...21,527,037 		JBrowse link
G Amt aminomethyltransferase ISO RGD PMID:20645850 RGD:7242560 NCBI chrNW_004955532:1,351,743...1,358,220
Ensembl chrNW_004955532:1,351,743...1,358,220 		JBrowse link
G Dhfr dihydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955418:29,274,170...29,283,028 JBrowse link
G Dld dihydrolipoamide dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chrNW_004955410:12,212,981...12,238,561
Ensembl chrNW_004955410:12,212,963...12,238,561 		JBrowse link
G Dmgdh dimethylglycine dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chrNW_004955425:22,045,977...22,103,381
Ensembl chrNW_004955425:22,045,993...22,102,852 		JBrowse link
G Folr1 folate receptor alpha ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955414:19,188,830...19,197,728
Ensembl chrNW_004955414:19,187,388...19,197,728 		JBrowse link
G Fpgs folylpolyglutamate synthase ISO RGD PMID:16859665 RGD:7242559 NCBI chrNW_004955419:853,891...871,729
Ensembl chrNW_004955419:851,152...871,522 		JBrowse link
G Gcsh glycine cleavage system protein H ISO RGD PMID:20645850 RGD:7242560 NCBI chrNW_004955522:3,858,156...3,869,730
Ensembl chrNW_004955522:3,857,628...3,870,228 		JBrowse link
G Ggh gamma-glutamyl hydrolase ISO RGD PMID:16859665 RGD:7242559 NCBI chrNW_004955444:15,901,225...15,930,358
Ensembl chrNW_004955444:15,900,485...15,931,338 		JBrowse link
G Gldc glycine decarboxylase ISO RGD PMID:20645850 RGD:7242560 NCBI chrNW_004955434:10,431,434...10,533,118
Ensembl chrNW_004955434:10,431,983...10,533,002 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955466:5,422,141...5,485,773
Ensembl chrNW_004955466:5,420,702...5,485,773 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955439:10,432,732...10,621,991
Ensembl chrNW_004955439:10,438,883...10,621,768 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO RGD PMID:20645850 PMID:22108709 RGD:7242557 RGD:7242560 NCBI chrNW_004955424:11,538,344...11,550,119
Ensembl chrNW_004955424:11,539,399...11,550,220 		JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955474:450,676...558,659
Ensembl chrNW_004955474:450,680...558,716 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955486:2,096,379...2,112,240
Ensembl chrNW_004955486:2,096,379...2,112,240 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955492:3,372,915...3,474,173
Ensembl chrNW_004955492:3,376,512...3,474,180 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955504:5,412,290...5,435,409
Ensembl chrNW_004955504:5,413,586...5,435,645 		JBrowse link
G Sardh sarcosine dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chrNW_004955513:2,933,918...2,975,645
Ensembl chrNW_004955513:2,933,918...2,976,931 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955478:10,972,791...11,001,535
Ensembl chrNW_004955478:10,978,139...11,001,202 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 ISO RGD PMID:20645850 PMID:22108709 RGD:7242557 RGD:7242560 NCBI chrNW_004955458:4,957,614...4,962,691
Ensembl chrNW_004955458:4,957,602...4,962,691 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 ISO RGD PMID:20814827 PMID:22108709 RGD:7242426 RGD:7242557 NCBI chrNW_004955407:42,132,216...42,154,252
Ensembl chrNW_004955407:42,132,165...42,141,992 		JBrowse link
G Slc25a32 solute carrier family 25 member 32 ISO RGD PMID:22332074 RGD:7242561 NCBI chrNW_004955417:27,530,806...27,545,103
Ensembl chrNW_004955417:27,527,144...27,546,043 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 ISO RGD PMID:20814827 PMID:22108709 RGD:7242426 RGD:7242557 NCBI chrNW_004955481:4,735,325...4,741,810
Ensembl chrNW_004955481:4,734,967...4,745,586 		JBrowse link
altered folate cycle metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family member L1 ISO RGD PMID:22353665 RGD:7242562 NCBI chrNW_004955421:21,420,264...21,506,004
Ensembl chrNW_004955421:21,420,147...21,527,037 		JBrowse link
G Dhfr dihydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955418:29,274,170...29,283,028 JBrowse link
G Folr1 folate receptor alpha ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955414:19,188,830...19,197,728
Ensembl chrNW_004955414:19,187,388...19,197,728 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955466:5,422,141...5,485,773
Ensembl chrNW_004955466:5,420,702...5,485,773 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955486:2,096,379...2,112,240
Ensembl chrNW_004955486:2,096,379...2,112,240 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955492:3,372,915...3,474,173
Ensembl chrNW_004955492:3,376,512...3,474,180 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955504:5,412,290...5,435,409
Ensembl chrNW_004955504:5,413,586...5,435,645 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955481:4,735,325...4,741,810
Ensembl chrNW_004955481:4,734,967...4,745,586 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3924
    classic metabolic pathway 966
      metabolic pathway of cofactors, vitamins, nutrients 226
        folate metabolic pathway 30
          folate cycle metabolic pathway 23
            altered folate cycle metabolic pathway 8
Path 2
Term Annotations click to browse term
  pathway 3924
    regulatory pathway 2432
      homeostasis pathway 1271
        organic chemical homeostasis pathway 345
          S-adenosylmethionine homeostasis pathway 258
            folate metabolic pathway 30
              folate cycle metabolic pathway 23
                altered folate cycle metabolic pathway 8
paths to the root