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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:altered folate metabolic pathway
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Accession:PW:0001189 term browser browse the term
Definition:A folate metabolic pathway that deviates from what its normal course should be. Impairment of folate cycle and/or folate mediated one-carbon pathways is associated with an increased risk for several conditions and developmental anomalies.


show annotations for term's descendants           Sort by:
altered folate cycle metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 ISO RGD PMID:22353665 RGD:7242562 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Dhfr dihydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Folr1 folate receptor alpha ISO RGD PMID:22108709 RGD:7242557 NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22108709 PMID:22108709 RGD:7242557, RGD:7242557 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848 		JBrowse link
altered folate mediated one-carbon metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22353665 RGD:7242562 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:22353665 RGD:7242562 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22353665 RGD:7242562 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    classic metabolic pathway 1854
      metabolic pathway of cofactors, vitamins, nutrients 367
        folate metabolic pathway 42
          altered folate metabolic pathway 8
            altered folate cycle metabolic pathway 8
            altered folate mediated one-carbon metabolic pathway 3
Path 2
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3867
      homeostasis pathway 1773
        organic chemical homeostasis pathway 438
          S-adenosylmethionine homeostasis pathway 289
            folate metabolic pathway 42
              altered folate metabolic pathway 8
                altered folate cycle metabolic pathway 8
                altered folate mediated one-carbon metabolic pathway 3
paths to the root