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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:calcium/calmodulin dependent kinase 2 signaling pathway
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Accession:PW:0001185 term browser browse the term
Definition:Calcium/calmodulin dependent kinase 2 (CAMK2) signaling plays important roles in excitation-contraction coupling in the heart and long-term potentiation (LPT) and memory in the brain.
Synonyms:exact_synonym: CAMKII signaling pathway
 related_synonym: CAMK2 signaling pathway
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calcium/calmodulin dependent kinase 2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit ISO RGD PMID:23091085 RGD:7240708 NCBI chr 6:118,564,201...119,174,345
Ensembl chr 6:118,564,201...119,173,851 		JBrowse link
G Cacnb2 calcium channel, voltage-dependent, beta 2 subunit ISO RGD PMID:23091085 RGD:7240708 NCBI chr 2:14,608,672...14,993,622
Ensembl chr 2:14,607,899...14,992,719 		JBrowse link
G Cacng2 calcium channel, voltage-dependent, gamma subunit 2 ISO RGD PMID:22334212 RGD:7240704 NCBI chr15:77,876,119...78,004,420
Ensembl chr15:77,875,948...78,004,228 		JBrowse link
G Calm1 calmodulin 1 ISO RGD PMID:22717267 PMID:23091085 RGD:7240705, RGD:7240708 NCBI chr12:100,165,694...100,176,083
Ensembl chr12:100,165,694...100,176,073 		JBrowse link
G Calm2 calmodulin 2 ISO RGD PMID:22717267 PMID:23091085 RGD:7240705, RGD:7240708 NCBI chr17:87,740,829...87,754,363
Ensembl chr17:87,740,840...87,754,363 		JBrowse link
G Calm3 calmodulin 3 ISO RGD PMID:22717267 PMID:23091085 RGD:7240705, RGD:7240708 NCBI chr 7:16,649,304...16,657,957
Ensembl chr 7:16,649,304...16,658,039 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO RGD PMID:22334212 PMID:22717267 RGD:7240704, RGD:7240705 NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II, beta ISO RGD PMID:22334212 PMID:22717267 RGD:7240704, RGD:7240705 NCBI chr11:5,919,642...6,016,401
Ensembl chr11:5,919,644...6,016,362 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II, delta ISO RGD PMID:22717267 PMID:23091085 RGD:7240705, RGD:7240708 NCBI chr 3:126,389,136...126,639,975
Ensembl chr 3:126,389,951...126,639,975 		JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma ISO RGD PMID:22717267 RGD:7240705 NCBI chr14:20,784,943...20,844,225
Ensembl chr14:20,784,943...20,844,156 		JBrowse link
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 ISO RGD PMID:21070840 PMID:21301225 RGD:7240706, RGD:7240707 NCBI chr 4:138,182,459...138,187,437
Ensembl chr 4:138,181,625...138,187,434 		JBrowse link
G Camk2n2 calcium/calmodulin-dependent protein kinase II inhibitor 2 ISO RGD PMID:21070840 PMID:21301225 RGD:7240706, RGD:7240707 NCBI chr16:20,437,965...20,440,028
Ensembl chr16:20,437,965...20,440,037 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 ISO RGD PMID:22717267 RGD:7240705 NCBI chr16:31,482,261...31,692,174
Ensembl chr16:31,482,261...31,693,947 		JBrowse link
G Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) ISO RGD PMID:22334212 RGD:7240704 NCBI chr11:56,902,342...57,221,070
Ensembl chr11:56,902,213...57,221,070 		JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) ISO RGD PMID:22717267 RGD:7240705 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199 		JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) ISO RGD PMID:22717267 RGD:7240705 NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424 		JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) ISO RGD PMID:22334212 PMID:22717267 RGD:7240704, RGD:7240705 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509 		JBrowse link
G Hdac4 histone deacetylase 4 ISO RGD PMID:21255680 RGD:7241019 NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421 		JBrowse link
G Hdac5 histone deacetylase 5 ISO RGD PMID:21255680 RGD:7241019 NCBI chr11:102,085,244...102,120,968
Ensembl chr11:102,085,258...102,120,992 		JBrowse link
G Lrrc7 leucine rich repeat containing 7 ISO RGD PMID:22717267 RGD:7240705 NCBI chr 3:157,772,823...158,268,254
Ensembl chr 3:157,788,528...158,267,858
Ensembl chr 3:157,788,528...158,267,858 		JBrowse link
G Pln phospholamban ISO RGD PMID:23091085 RGD:7240708 NCBI chr10:53,213,782...53,222,095
Ensembl chr10:53,213,763...53,222,083 		JBrowse link
G Ppm1e protein phosphatase 1E (PP2C domain containing) ISO RGD PMID:18454172 RGD:7241020 NCBI chr11:87,117,724...87,249,884
Ensembl chr11:87,117,732...87,249,849 		JBrowse link
G Ppm1f protein phosphatase 1F (PP2C domain containing) ISO RGD PMID:18454172 RGD:7241020 NCBI chr16:16,714,314...16,745,239
Ensembl chr16:16,714,333...16,745,228 		JBrowse link
G Ppp1cc protein phosphatase 1 catalytic subunit gamma ISO RGD PMID:18454172 RGD:7241020 NCBI chr 5:122,296,338...122,313,336
Ensembl chr 5:122,296,341...122,313,336 		JBrowse link
G Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform ISO RGD PMID:18454172 RGD:7241020 NCBI chr11:51,989,651...52,013,576
Ensembl chr11:51,989,508...52,018,605 		JBrowse link
G Ryr2 ryanodine receptor 2, cardiac ISO RGD PMID:23091085 RGD:7240708 NCBI chr13:11,567,985...12,121,831
Ensembl chr13:11,567,988...12,121,831 		JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha ISO RGD PMID:23091085 RGD:7240708 NCBI chr 9:119,312,470...119,408,096
Ensembl chr 9:119,312,474...119,408,082 		JBrowse link
G Syngap1 synaptic Ras GTPase activating protein 1 homolog (rat) ISO RGD PMID:22717267 RGD:7240705 NCBI chr17:27,160,186...27,191,408
Ensembl chr17:27,160,227...27,191,408 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6074
    signaling pathway 2500
      calcium/calcium-mediated signaling pathway 135
        calcium/calmodulin dependent signaling pathway 38
          calcium/calmodulin dependent kinase signaling pathway 29
            calcium/calmodulin dependent kinase 2 signaling pathway 28
Path 2
Term Annotations click to browse term
  pathway 6074
    regulatory pathway 3686
      homeostasis pathway 1721
        inorganic chemical homeostasis pathway 294
          metal homeostasis pathway 202
            calcium homeostasis pathway 140
              calcium/calcium-mediated signaling pathway 135
                calcium/calmodulin dependent signaling pathway 38
                  calcium/calmodulin dependent kinase signaling pathway 29
                    calcium/calmodulin dependent kinase 2 signaling pathway 28
paths to the root