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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:phosphate homeostasis pathway
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Accession:PW:0001182 term browser browse the term
Definition:Phosphate is an essential element with many important roles in biology, from skeletal development and integrity to metabolism and cellular signaling. The greatest amount of phosphate is found in bone and teeth. The major regulator of phosphate homeostasis is the kidney. Maintenance of proper phosphate levels is assured by an interplay of transport and signaling pathways. Sodium phosphate co-transporters, primarily type 2 and 3 and parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) signaling are essential components.


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parathyroid hormone signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb1 arrestin, beta 1 ISO RGD PMID:20703892 RGD:7207469 NCBI chr 1:163,249,654...163,321,711
Ensembl chr 1:153,838,078...153,904,061 		JBrowse link
G Arrb2 arrestin, beta 2 ISO RGD PMID:20703892 RGD:7207469 NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Ezr ezrin ISO RGD PMID:21777186 RGD:7207465 NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:46,967,658...47,011,505 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:19395963 RGD:7207470 NCBI chr 1:211,010,259...211,031,013
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Nherf1 NHERF family PDZ scaffold protein 1 ISO RGD PMID:21777186 RGD:7207465 NCBI chr10:100,902,165...100,919,265
Ensembl chr10:100,403,069...100,420,598 		JBrowse link
G Nherf2 NHERF family PDZ scaffold protein 2 ISO RGD PMID:21777186 RGD:7207465 NCBI chr10:14,167,005...14,177,519
Ensembl chr10:13,662,461...13,673,049 		JBrowse link
G Pth parathyroid hormone IDA
ISO		 RGD PMID:9054374 PMID:19395963 PMID:21777186 RGD:7207455, RGD:7207470, RGD:7207465 NCBI chr 1:176,942,901...176,946,034
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Pth1r parathyroid hormone 1 receptor IDA
ISO		 RGD PMID:9054374 PMID:19395963 PMID:20703892 PMID:21777186 RGD:7207455, RGD:7207470, RGD:7207469, RGD:7207465 NCBI chr 8:119,572,295...119,597,405
Ensembl chr 8:110,697,485...110,719,729 		JBrowse link
phosphate transport pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc20a1 solute carrier family 20 member 1 ISO RGD PMID:21778753 RGD:7207819 NCBI chr 3:136,880,360...136,894,255
Ensembl chr 3:116,427,098...116,441,051 		JBrowse link
G Slc20a2 solute carrier family 20 member 2 ISO RGD PMID:21778753 RGD:7207819 NCBI chr16:76,163,315...76,253,881
Ensembl chr16:69,460,462...69,521,711 		JBrowse link
G Slc34a1 solute carrier family 34 member 1 ISO RGD PMID:21778753 RGD:7207819 NCBI chr17:9,224,010...9,238,983
Ensembl chr17:9,218,876...9,233,852 		JBrowse link
G Slc34a2 solute carrier family 34 member 2 ISO RGD PMID:21778753 RGD:7207819 NCBI chr14:62,123,313...62,153,020
Ensembl chr14:57,910,480...57,930,436 		JBrowse link
G Slc34a3 solute carrier family 34 member 3 ISO RGD PMID:21778753 RGD:7207819 NCBI chr 3:28,442,455...28,447,997
Ensembl chr 3:8,044,296...8,049,970 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3866
      homeostasis pathway 1773
        inorganic chemical homeostasis pathway 430
          phosphate homeostasis pathway 13
            altered phosphate homeostasis pathway 0
            fibroblast growth factor 23 signaling pathway + 0
            parathyroid hormone signaling pathway 8
            phosphate transport pathway 5
paths to the root