Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:calcium signaling pathway via the calcium-sensing receptor
go back to main search page
Accession:PW:0001141 term browser browse the term
Definition:Calcium signaling through the calcium-sensing receptor inhibits the secretion of parathyroid hormone in the parathyroid glands and controls calcium absorption and water balance in the kidneys. Calcium is considered the main physiological agonist but other cations and various agonists can activate the receptor. The G protein coupled receptor (GPCR) is believed to engage several types of Galpha proteins and to have many other interacting partners. The pathway leads to activation of MAPK cascades, particularly the one mediated by Erk1/2. Casr signaling is cell specific; many of its molecular details are not fully understood. Many mutations, both inactivating and activating the receptor, have been identified.
View Interactive Diagram


show annotations for term's descendants           Sort by:
calcium signaling pathway via the calcium-sensing receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRB1 arrestin beta 1 ISO RGD PMID:15637145 PMID:22192592 RGD:7207059 RGD:7207060 NCBI chr 9:9,516,944...9,597,446
Ensembl chr 9:9,516,947...9,597,976 		JBrowse link
G ARRB2 arrestin beta 2 ISO RGD PMID:15637145 PMID:22192592 RGD:7207059 RGD:7207060 NCBI chr12:52,161,776...52,170,362
Ensembl chr12:52,161,778...52,170,342 		JBrowse link
G CASR calcium sensing receptor ISO RGD PMID:12239094 PMID:15637145 PMID:22192592 RGD:7207059 RGD:7207060 RGD:7207227 NCBI chr13:138,279,785...138,364,934
Ensembl chr13:138,280,364...138,364,252 		JBrowse link
G FLNA filamin A ISO RGD PMID:12239094 RGD:7207227 NCBI chr  X:124,889,934...124,915,000
Ensembl chr  X:124,890,162...124,914,992 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:15637145 RGD:7207060 NCBI chr 2:5,209,435...5,227,543
Ensembl chr 2:5,209,439...5,227,758 		JBrowse link
G GRK3 G protein-coupled receptor kinase 3 ISO RGD PMID:15637145 RGD:7207060 NCBI chr14:43,305,255...43,445,626
Ensembl chr14:43,224,930...43,442,965 		JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:15637145 RGD:7207060 NCBI chr 8:1,737,960...1,792,390
Ensembl chr 8:1,738,333...1,792,374 		JBrowse link
G RGS12 regulator of G protein signaling 12 ISO RGD PMID:12239094 RGD:7207227 NCBI chr 8:1,971,390...2,074,970
Ensembl chr 8:1,963,308...2,075,971 		JBrowse link
G RGS2 regulator of G protein signaling 2 ISO RGD PMID:12239094 RGD:7207227 NCBI chr10:936,836...940,083
Ensembl chr10:936,789...940,098 		JBrowse link
G RGS4 regulator of G protein signaling 4 ISO RGD PMID:12239094 RGD:7207227 NCBI chr 4:87,383,336...87,390,478
Ensembl chr 4:87,383,345...87,390,893 		JBrowse link
G RGS5 regulator of G protein signaling 5 ISO RGD PMID:21393447 RGD:7207228 NCBI chr 4:87,286,953...87,340,816
Ensembl chr 4:87,286,953...87,342,088 		JBrowse link
G RHOA ras homolog family member A ISO RGD PMID:12239094 RGD:7207227 NCBI chr13:31,918,484...31,991,207
Ensembl chr13:31,918,834...31,986,607 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4041
    signaling pathway 1918
      calcium/calcium-mediated signaling pathway 132
        calcium signaling pathway via the calcium-sensing receptor 12
          altered calcium signaling pathway via the calcium-sensing receptor 0
Path 2
Term Annotations click to browse term
  pathway 4041
    regulatory pathway 2489
      homeostasis pathway 1301
        inorganic chemical homeostasis pathway 288
          metal homeostasis pathway 198
            calcium homeostasis pathway 137
              calcium/calcium-mediated signaling pathway 132
                calcium signaling pathway via the calcium-sensing receptor 12
                  altered calcium signaling pathway via the calcium-sensing receptor 0
paths to the root