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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:calcium signaling pathway via the calcium-sensing receptor
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Accession:PW:0001141 term browser browse the term
Definition:Calcium signaling through the calcium-sensing receptor inhibits the secretion of parathyroid hormone in the parathyroid glands and controls calcium absorption and water balance in the kidneys. Calcium is considered the main physiological agonist but other cations and various agonists can activate the receptor. The G protein coupled receptor (GPCR) is believed to engage several types of Galpha proteins and to have many other interacting partners. The pathway leads to activation of MAPK cascades, particularly the one mediated by Erk1/2. Casr signaling is cell specific; many of its molecular details are not fully understood. Many mutations, both inactivating and activating the receptor, have been identified.
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calcium signaling pathway via the calcium-sensing receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb1 arrestin beta 1 ISO RGD PMID:15637145 PMID:22192592 RGD:7207059 RGD:7207060 NCBI chrNW_004624817:1,750,448...1,828,399
Ensembl chrNW_004624817:1,750,156...1,823,309 		JBrowse link
G Arrb2 arrestin beta 2 ISO RGD PMID:15637145 PMID:22192592 RGD:7207059 RGD:7207060 NCBI chrNW_004624786:8,568,102...8,576,445
Ensembl chrNW_004624786:8,568,198...8,577,914 		JBrowse link
G Casr calcium sensing receptor ISO RGD PMID:12239094 PMID:15637145 PMID:22192592 RGD:7207059 RGD:7207060 RGD:7207227 NCBI chrNW_004624912:485,252...613,572
Ensembl chrNW_004624912:485,258...614,656 		JBrowse link
G Flna filamin A ISO RGD PMID:12239094 RGD:7207227 NCBI chrNW_004624946:812,278...836,307
Ensembl chrNW_004624946:812,287...837,273 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:15637145 RGD:7207060 NCBI chrNW_004624767:19,212,218...19,231,218
Ensembl chrNW_004624767:19,210,965...19,231,082 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO RGD PMID:15637145 RGD:7207060 NCBI chrNW_004624747:1,567,540...1,758,251
Ensembl chrNW_004624747:1,576,681...1,758,201 		JBrowse link
G Grk4 G protein-coupled receptor kinase 4 ISO RGD PMID:15637145 RGD:7207060 NCBI chrNW_004624755:24,741,985...24,789,972
Ensembl chrNW_004624755:24,742,073...24,830,314 		JBrowse link
G Rgs12 regulator of G protein signaling 12 ISO RGD PMID:12239094 RGD:7207227 NCBI chrNW_004624755:24,489,746...24,567,937
Ensembl chrNW_004624755:24,489,966...24,553,505 		JBrowse link
G Rgs2 regulator of G protein signaling 2 ISO RGD PMID:12239094 RGD:7207227 NCBI chrNW_004624814:754,743...758,148
Ensembl chrNW_004624814:753,164...758,192 		JBrowse link
G Rgs4 regulator of G protein signaling 4 ISO RGD PMID:12239094 RGD:7207227 NCBI chrNW_004624826:1,570,143...1,577,300
Ensembl chrNW_004624826:1,569,854...1,579,627 		JBrowse link
G Rgs5 regulator of G protein signaling 5 ISO RGD PMID:21393447 RGD:7207228 NCBI chrNW_004624826:1,644,874...1,698,855
Ensembl chrNW_004624826:1,648,891...1,699,353 		JBrowse link
G Rhoa ras homolog family member A ISO RGD PMID:12239094 RGD:7207227 NCBI chrNW_004624730:3,316,122...3,361,820 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3917
    signaling pathway 1875
      calcium/calcium-mediated signaling pathway 129
        calcium signaling pathway via the calcium-sensing receptor 12
          altered calcium signaling pathway via the calcium-sensing receptor 0
Path 2
Term Annotations click to browse term
  pathway 3917
    regulatory pathway 2426
      homeostasis pathway 1267
        inorganic chemical homeostasis pathway 280
          metal homeostasis pathway 194
            calcium homeostasis pathway 134
              calcium/calcium-mediated signaling pathway 129
                calcium signaling pathway via the calcium-sensing receptor 12
                  altered calcium signaling pathway via the calcium-sensing receptor 0
paths to the root