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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:calcium signaling pathway via the calcium-sensing receptor
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Accession:PW:0001141 term browser browse the term
Definition:Calcium signaling through the calcium-sensing receptor inhibits the secretion of parathyroid hormone in the parathyroid glands and controls calcium absorption and water balance in the kidneys. Calcium is considered the main physiological agonist but other cations and various agonists can activate the receptor. The G protein coupled receptor (GPCR) is believed to engage several types of Galpha proteins and to have many other interacting partners. The pathway leads to activation of MAPK cascades, particularly the one mediated by Erk1/2. Casr signaling is cell specific; many of its molecular details are not fully understood. Many mutations, both inactivating and activating the receptor, have been identified.
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calcium signaling pathway via the calcium-sensing receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRB1 arrestin beta 1 IDA
ISO		 RGD PMID:15637145 PMID:22192592 RGD:7207060, RGD:7207059 NCBI chr11:75,260,122...75,351,661
Ensembl chr11:75,260,122...75,351,705 		JBrowse link
G ARRB2 arrestin beta 2 IDA
ISO		 RGD PMID:15637145 PMID:22192592 RGD:7207060, RGD:7207059 NCBI chr17:4,710,632...4,721,497
Ensembl chr17:4,710,596...4,721,499 		JBrowse link
G CASR calcium sensing receptor ISO RGD PMID:22192592 PMID:12239094 PMID:15637145 RGD:7207059, RGD:7207227, RGD:7207060 NCBI chr 3:122,183,668...122,291,629
Ensembl chr 3:122,183,668...122,291,629 		JBrowse link
G FLNA filamin A IMP RGD PMID:12239094 RGD:7207227 NCBI chr  X:154,348,531...154,374,634
Ensembl chr  X:154,348,524...154,374,634 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 IDA RGD PMID:15637145 RGD:7207060 NCBI chr11:67,266,473...67,286,556
Ensembl chr11:67,266,473...67,286,556 		JBrowse link
G GRK3 G protein-coupled receptor kinase 3 IDA RGD PMID:15637145 RGD:7207060 NCBI chr22:25,564,675...25,729,294
Ensembl chr22:25,564,675...25,729,294 		JBrowse link
G GRK4 G protein-coupled receptor kinase 4 IDA RGD PMID:15637145 RGD:7207060 NCBI chr 4:2,963,571...3,040,760
Ensembl chr 4:2,963,571...3,040,760 		JBrowse link
G RGS12 regulator of G protein signaling 12 TAS RGD PMID:12239094 RGD:7207227 NCBI chr 4:3,285,891...3,439,913
Ensembl chr 4:3,293,021...3,439,913 		JBrowse link
G RGS2 regulator of G protein signaling 2 IEP RGD PMID:12239094 RGD:7207227 NCBI chr 1:192,809,039...192,812,275
Ensembl chr 1:192,809,039...192,812,275 		JBrowse link
G RGS4 regulator of G protein signaling 4 IEP RGD PMID:12239094 RGD:7207227 NCBI chr 1:163,068,871...163,076,802
Ensembl chr 1:163,068,775...163,076,802 		JBrowse link
G RGS5 regulator of G protein signaling 5 IEP RGD PMID:21393447 RGD:7207228 NCBI chr 1:163,142,299...163,321,735
Ensembl chr 1:163,111,121...163,321,791 		JBrowse link
G RHOA ras homolog family member A IMP RGD PMID:12239094 RGD:7207227 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5957
    signaling pathway 2493
      calcium/calcium-mediated signaling pathway 134
        calcium signaling pathway via the calcium-sensing receptor 12
          altered calcium signaling pathway via the calcium-sensing receptor 0
Path 2
Term Annotations click to browse term
  pathway 5957
    regulatory pathway 3600
      homeostasis pathway 1667
        inorganic chemical homeostasis pathway 293
          metal homeostasis pathway 201
            calcium homeostasis pathway 139
              calcium/calcium-mediated signaling pathway 134
                calcium signaling pathway via the calcium-sensing receptor 12
                  altered calcium signaling pathway via the calcium-sensing receptor 0
paths to the root