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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:calcium signaling pathway via the calcium-sensing receptor
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Accession:PW:0001141 term browser browse the term
Definition:Calcium signaling through the calcium-sensing receptor inhibits the secretion of parathyroid hormone in the parathyroid glands and controls calcium absorption and water balance in the kidneys. Calcium is considered the main physiological agonist but other cations and various agonists can activate the receptor. The G protein coupled receptor (GPCR) is believed to engage several types of Galpha proteins and to have many other interacting partners. The pathway leads to activation of MAPK cascades, particularly the one mediated by Erk1/2. Casr signaling is cell specific; many of its molecular details are not fully understood. Many mutations, both inactivating and activating the receptor, have been identified.
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calcium signaling pathway via the calcium-sensing receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRB1 arrestin beta 1 ISO RGD PMID:15637145 PMID:22192592 RGD:7207059 RGD:7207060 NCBI chr 1:66,489,358...66,580,167
Ensembl chr 1:66,490,102...66,580,154 		JBrowse link
G ARRB2 arrestin beta 2 ISO RGD PMID:15637145 PMID:22192592 RGD:7207059 RGD:7207060 NCBI chr16:4,191,040...4,202,382
Ensembl chr16:4,191,172...4,202,385 		JBrowse link
G CASR calcium sensing receptor ISO RGD PMID:12239094 PMID:15637145 PMID:22192592 RGD:7207059 RGD:7207060 RGD:7207227 NCBI chr22:58,579,640...58,612,142
Ensembl chr22:58,578,396...58,604,756 		JBrowse link
G FLNA filamin A ISO RGD PMID:12239094 RGD:7207227 NCBI chr  X:128,657,580...128,683,812
Ensembl chr  X:128,657,393...128,680,531 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:15637145 RGD:7207060 NCBI chr 1:6,975,202...6,995,369
Ensembl chr 1:6,975,002...6,995,259 		JBrowse link
G GRK3 G protein-coupled receptor kinase 3 ISO RGD PMID:15637145 RGD:7207060 NCBI chr19:8,438,543...8,601,652
Ensembl chr19:8,438,380...8,600,359 		JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:15637145 RGD:7207060 NCBI chr27:45,691,936...45,765,334 JBrowse link
G RGS12 regulator of G protein signaling 12 ISO RGD PMID:12239094 RGD:7207227 NCBI chr27:45,302,193...45,444,012 JBrowse link
G RGS2 regulator of G protein signaling 2 ISO RGD PMID:12239094 RGD:7207227 NCBI chr25:36,620,047...36,623,367
Ensembl chr25:36,619,140...36,623,308 		JBrowse link
G RGS4 regulator of G protein signaling 4 ISO RGD PMID:12239094 RGD:7207227 NCBI chr25:65,729,344...65,735,278
Ensembl chr25:65,726,394...65,735,381 		JBrowse link
G RGS5 regulator of G protein signaling 5 ISO RGD PMID:21393447 RGD:7207228 NCBI chr25:65,608,384...65,667,811
Ensembl chr25:65,608,303...65,662,772 		JBrowse link
G RHOA ras homolog family member A ISO RGD PMID:12239094 RGD:7207227 NCBI chr22:10,757,381...10,809,257
Ensembl chr22:10,757,337...10,772,704 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4028
    signaling pathway 1919
      calcium/calcium-mediated signaling pathway 132
        calcium signaling pathway via the calcium-sensing receptor 12
          altered calcium signaling pathway via the calcium-sensing receptor 0
Path 2
Term Annotations click to browse term
  pathway 4028
    regulatory pathway 2488
      homeostasis pathway 1295
        inorganic chemical homeostasis pathway 287
          metal homeostasis pathway 197
            calcium homeostasis pathway 137
              calcium/calcium-mediated signaling pathway 132
                calcium signaling pathway via the calcium-sensing receptor 12
                  altered calcium signaling pathway via the calcium-sensing receptor 0
paths to the root