Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:calcium signaling pathway via the calcium-sensing receptor
go back to main search page
Accession:PW:0001141 term browser browse the term
Definition:Calcium signaling through the calcium-sensing receptor inhibits the secretion of parathyroid hormone in the parathyroid glands and controls calcium absorption and water balance in the kidneys. Calcium is considered the main physiological agonist but other cations and various agonists can activate the receptor. The G protein coupled receptor (GPCR) is believed to engage several types of Galpha proteins and to have many other interacting partners. The pathway leads to activation of MAPK cascades, particularly the one mediated by Erk1/2. Casr signaling is cell specific; many of its molecular details are not fully understood. Many mutations, both inactivating and activating the receptor, have been identified.
View Interactive Diagram

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
calcium signaling pathway via the calcium-sensing receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb1 arrestin beta 1 ISO RGD PMID:15637145 PMID:22192592 RGD:7207059 RGD:7207060 NCBI chrNW_004955414:16,478,843...16,568,050
Ensembl chrNW_004955414:16,478,843...16,562,135 		JBrowse link
G Arrb2 arrestin beta 2 ISO RGD PMID:15637145 PMID:22192592 RGD:7207059 RGD:7207060 NCBI chrNW_004955467:10,109,985...10,118,687
Ensembl chrNW_004955467:10,110,003...10,123,022 		JBrowse link
G Casr calcium sensing receptor ISO RGD PMID:12239094 PMID:15637145 PMID:22192592 RGD:7207059 RGD:7207060 RGD:7207227 NCBI chrNW_004955427:21,486,608...21,574,017
Ensembl chrNW_004955427:21,486,427...21,575,210 		JBrowse link
G Flna filamin A ISO RGD PMID:12239094 RGD:7207227 NCBI chrNW_004955580:874,233...895,172
Ensembl chrNW_004955580:874,233...895,232 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:15637145 RGD:7207060 NCBI chrNW_004955422:18,173,438...18,192,357
Ensembl chrNW_004955422:18,170,616...18,192,412 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO RGD PMID:15637145 RGD:7207060 NCBI chrNW_004955442:19,640,145...19,785,803
Ensembl chrNW_004955442:19,640,145...19,785,803 		JBrowse link
G Grk4 G protein-coupled receptor kinase 4 ISO RGD PMID:15637145 RGD:7207060 NCBI chrNW_004955514:1,837,141...1,895,785
Ensembl chrNW_004955514:1,837,141...1,895,785 		JBrowse link
G Rgs12 regulator of G protein signaling 12 ISO RGD PMID:12239094 RGD:7207227 NCBI chrNW_004955514:2,081,575...2,154,414
Ensembl chrNW_004955514:2,088,354...2,154,191 		JBrowse link
G Rgs2 regulator of G protein signaling 2 ISO RGD PMID:12239094 RGD:7207227 NCBI chrNW_004955406:30,261,757...30,265,389
Ensembl chrNW_004955406:30,261,757...30,266,005 		JBrowse link
G Rgs4 regulator of G protein signaling 4 ISO RGD PMID:12239094 RGD:7207227 NCBI chrNW_004955462:13,340,812...13,347,598
Ensembl chrNW_004955462:13,338,960...13,347,610 		JBrowse link
G Rgs5 regulator of G protein signaling 5 ISO RGD PMID:21393447 RGD:7207228 NCBI chrNW_004955462:13,228,110...13,288,063
Ensembl chrNW_004955462:13,228,002...13,283,034 		JBrowse link
G Rhoa ras homolog family member A ISO RGD PMID:12239094 RGD:7207227 NCBI chrNW_004955532:1,300,821...1,347,453
Ensembl chrNW_004955532:1,300,462...1,347,451 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3924
    signaling pathway 1879
      calcium/calcium-mediated signaling pathway 131
        calcium signaling pathway via the calcium-sensing receptor 12
          altered calcium signaling pathway via the calcium-sensing receptor 0
Path 2
Term Annotations click to browse term
  pathway 3924
    regulatory pathway 2432
      homeostasis pathway 1271
        inorganic chemical homeostasis pathway 289
          metal homeostasis pathway 197
            calcium homeostasis pathway 136
              calcium/calcium-mediated signaling pathway 131
                calcium signaling pathway via the calcium-sensing receptor 12
                  altered calcium signaling pathway via the calcium-sensing receptor 0
paths to the root