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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:calcium signaling pathway via the calcium-sensing receptor
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Accession:PW:0001141 term browser browse the term
Definition:Calcium signaling through the calcium-sensing receptor inhibits the secretion of parathyroid hormone in the parathyroid glands and controls calcium absorption and water balance in the kidneys. Calcium is considered the main physiological agonist but other cations and various agonists can activate the receptor. The G protein coupled receptor (GPCR) is believed to engage several types of Galpha proteins and to have many other interacting partners. The pathway leads to activation of MAPK cascades, particularly the one mediated by Erk1/2. Casr signaling is cell specific; many of its molecular details are not fully understood. Many mutations, both inactivating and activating the receptor, have been identified.
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calcium signaling pathway via the calcium-sensing receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRB1 arrestin beta 1 ISO RGD PMID:15637145 PMID:22192592 RGD:7207059 RGD:7207060 NCBI chr11:70,319,935...70,411,276
Ensembl chr11:73,630,276...73,654,155 		JBrowse link
G ARRB2 arrestin beta 2 ISO RGD PMID:15637145 PMID:22192592 RGD:7207059 RGD:7207060 NCBI chr17:4,766,616...4,777,253
Ensembl chr17:4,757,048...4,767,517 		JBrowse link
G CASR calcium sensing receptor ISO RGD PMID:12239094 PMID:15637145 PMID:22192592 RGD:7207059 RGD:7207060 RGD:7207227 NCBI chr 3:119,278,071...119,383,901
Ensembl chr 3:126,252,765...126,285,268 		JBrowse link
G FLNA filamin A ISO RGD PMID:12239094 RGD:7207227 NCBI chr  X:143,799,088...143,825,282 JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:15637145 RGD:7207060 NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066 		JBrowse link
G GRK3 G protein-coupled receptor kinase 3 ISO RGD PMID:15637145 RGD:7207060 NCBI chr22:6,579,664...6,789,846
Ensembl chr22:24,353,533...24,509,560 		JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:15637145 RGD:7207060 NCBI chr 4:3,106,064...3,181,270
Ensembl chr 4:3,008,126...3,083,094 		JBrowse link
G RGS12 regulator of G protein signaling 12 ISO RGD PMID:12239094 RGD:7207227 NCBI chr 4:3,439,030...3,589,026
Ensembl chr 4:3,444,570...3,573,712 		JBrowse link
G RGS2 regulator of G protein signaling 2 ISO RGD PMID:12239094 RGD:7207227 NCBI chr 1:168,273,112...168,276,348
Ensembl chr 1:172,566,701...172,569,955 		JBrowse link
G RGS4 regulator of G protein signaling 4 ISO RGD PMID:12239094 RGD:7207227 NCBI chr 1:138,488,317...138,496,497
Ensembl chr 1:142,284,040...142,292,225 		JBrowse link
G RGS5 regulator of G protein signaling 5 ISO RGD PMID:21393447 RGD:7207228 NCBI chr 1:138,561,940...138,622,698
Ensembl chr 1:142,362,663...142,387,291 		JBrowse link
G RHOA ras homolog family member A ISO RGD PMID:12239094 RGD:7207227 NCBI chr 3:49,282,009...49,339,887 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4064
    signaling pathway 1930
      calcium/calcium-mediated signaling pathway 133
        calcium signaling pathway via the calcium-sensing receptor 12
          altered calcium signaling pathway via the calcium-sensing receptor 0
Path 2
Term Annotations click to browse term
  pathway 4064
    regulatory pathway 2507
      homeostasis pathway 1306
        inorganic chemical homeostasis pathway 292
          metal homeostasis pathway 200
            calcium homeostasis pathway 138
              calcium/calcium-mediated signaling pathway 133
                calcium signaling pathway via the calcium-sensing receptor 12
                  altered calcium signaling pathway via the calcium-sensing receptor 0
paths to the root