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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:calcium transport pathway
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Accession:PW:0001139 term browser browse the term
Definition:Calcium is pumped into organelles or out of the cell by pumps and exchangers to maintain the low calcium concentration necessary for cell viability. Many type of channels, some calcium-selective, others of lower selectivity or calcium-permeant, allow for the flow of calcium from external sources or internal stores into the cell to initiate many signaling events. The movement of calcium ions, which controls and maintains the calcium gradient, and calcium signaling, which the gradient promotes, are inextricably connected in the fabric of calcium homeostasis.
Synonyms:related_synonym: calcium ion transport
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calcium transport pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004936501:11,818,301...11,836,221
Ensembl chrNW_004936501:11,816,585...11,836,231 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004936558:3,300,941...3,357,595
Ensembl chrNW_004936558:3,300,941...3,357,941 		JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004936677:552,066...585,093
Ensembl chrNW_004936677:551,933...585,114 		JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004936507:6,525,302...6,631,003
Ensembl chrNW_004936507:6,523,199...6,630,606 		JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004936602:2,744,757...3,011,051
Ensembl chrNW_004936602:2,744,759...3,007,940 		JBrowse link
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004936809:396,883...466,372
Ensembl chrNW_004936809:396,733...466,524 		JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004936567:944,825...1,039,920
Ensembl chrNW_004936567:950,797...993,245 		JBrowse link
G Atp2c1 ATPase secretory pathway Ca2+ transporting 1 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004936529:4,340,131...4,474,884
Ensembl chrNW_004936529:4,361,424...4,474,436 		JBrowse link
G Atp2c2 ATPase secretory pathway Ca2+ transporting 2 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004936641:3,498,693...3,547,968
Ensembl chrNW_004936641:3,498,693...3,547,968 		JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004936669:133,488...308,623
Ensembl chrNW_004936669:133,698...308,488 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004936606:2,168,104...2,867,560
Ensembl chrNW_004936606:2,168,625...2,865,758 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004936473:4,164,633...4,479,866
Ensembl chrNW_004936473:4,037,533...4,478,073 		JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004936481:7,694,960...7,908,683
Ensembl chrNW_004936481:7,702,152...7,993,263 		JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004936721:1,078,570...1,106,153
Ensembl chrNW_004936721:1,078,650...1,106,113 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004936490:11,093,600...11,157,756
Ensembl chrNW_004936490:11,093,595...11,157,563 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004936694:2,702,224...2,724,574 JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004936492:1,990,430...2,030,744
Ensembl chrNW_004936492:1,998,793...2,075,257 		JBrowse link
G Cacna1s calcium voltage-gated channel subunit alpha1 S ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004936567:3,269,283...3,331,858
Ensembl chrNW_004936567:3,269,355...3,331,460 		JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004936490:14,448,305...14,468,785
Ensembl chrNW_004936490:14,448,258...14,468,785 		JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004936520:8,951,994...9,164,039
Ensembl chrNW_004936520:8,955,164...9,295,331 		JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004936512:6,652,836...6,666,171
Ensembl chrNW_004936512:6,653,777...6,666,758 		JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004936469:25,494,820...25,745,783
Ensembl chrNW_004936469:25,494,883...25,740,223 		JBrowse link
G Cnga1 cyclic nucleotide gated channel subunit alpha 1 ISO RGD PMID:12087135 RGD:6893549 NCBI chrNW_004936482:14,091,343...14,107,793
Ensembl chrNW_004936482:14,091,913...14,107,787 		JBrowse link
G Cnga2 cyclic nucleotide gated channel subunit alpha 2 ISO RGD PMID:12087135 RGD:6893549 NCBI chrNW_004936714:1,011,736...1,017,722
Ensembl chrNW_004936714:1,011,736...1,017,729 		JBrowse link
G Cnga3 cyclic nucleotide gated channel subunit alpha 3 ISO RGD PMID:12087135 RGD:6893549 NCBI chrNW_004936744:1,499,431...1,537,784
Ensembl chrNW_004936744:1,514,821...1,540,580 		JBrowse link
G Cnga4 cyclic nucleotide gated channel subunit alpha 4 ISO RGD PMID:12087135 RGD:6893549 NCBI chrNW_004936842:310,741...314,754
Ensembl chrNW_004936842:310,741...314,754 		JBrowse link
G Cngb1 cyclic nucleotide gated channel subunit beta 1 ISO RGD PMID:12087135 RGD:6893549 NCBI chrNW_004936475:9,844,438...9,908,009 JBrowse link
G Cngb3 cyclic nucleotide gated channel subunit beta 3 ISO RGD PMID:12087135 RGD:6893549 NCBI chrNW_004936544:1,166,896...1,305,339
Ensembl chrNW_004936544:1,166,508...1,305,457 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor type 1 ISO RGD PMID:19133301 RGD:7204693 NCBI chrNW_004936577:3,896,455...4,198,396
Ensembl chrNW_004936577:3,896,390...4,198,411 		JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor type 2 ISO RGD PMID:19133301 RGD:7204693 NCBI chrNW_004936548:646,019...1,120,426
Ensembl chrNW_004936548:645,925...1,121,888 		JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor type 3 ISO RGD PMID:19133301 RGD:7204693 NCBI chrNW_004936476:25,254,937...25,318,316
Ensembl chrNW_004936476:25,254,932...25,318,491 		JBrowse link
G LOC101960999 voltage-dependent P/Q-type calcium channel subunit alpha-1A ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004936659:2,201,606...2,269,625
Ensembl chrNW_004936659:2,192,610...2,392,638 		JBrowse link
G Mcoln1 mucolipin TRP cation channel 1 ISO RGD PMID:20716668 RGD:7204689 NCBI chrNW_004936588:4,600,344...4,608,793
Ensembl chrNW_004936588:4,600,344...4,608,787 		JBrowse link
G Mcu mitochondrial calcium uniporter ISO RGD PMID:22850819 RGD:7204696 NCBI chrNW_004936521:6,129,392...6,191,035
Ensembl chrNW_004936521:6,131,216...6,313,830 		JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 ISO RGD PMID:22914293 RGD:7204692 NCBI chrNW_004936558:2,730,098...2,743,062 JBrowse link
G Orai2 ORAI calcium release-activated calcium modulator 2 ISO RGD PMID:22914293 RGD:7204692 NCBI chrNW_004936543:1,867,148...1,880,289
Ensembl chrNW_004936543:1,846,242...1,880,291 		JBrowse link
G Orai3 ORAI calcium release-activated calcium modulator 3 ISO RGD PMID:22914293 RGD:7204692 NCBI chrNW_004936501:13,332,859...13,338,838
Ensembl chrNW_004936501:13,332,757...13,339,324 		JBrowse link
G Ryr1 ryanodine receptor 1 ISO RGD PMID:20961976 RGD:7204694 NCBI chrNW_004936801:1,185,615...1,298,416
Ensembl chrNW_004936801:1,185,733...1,298,289 		JBrowse link
G Ryr2 ryanodine receptor 2 ISO RGD PMID:20961976 RGD:7204694 NCBI chrNW_004936484:15,402,488...15,825,410
Ensembl chrNW_004936484:15,403,819...15,824,441 		JBrowse link
G Ryr3 ryanodine receptor 3 ISO RGD PMID:20961976 RGD:7204694 NCBI chrNW_004936673:2,078,095...2,434,872
Ensembl chrNW_004936673:1,932,755...2,434,066 		JBrowse link
G Slc24a1 solute carrier family 24 member 1 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004936471:25,872,854...25,909,102
Ensembl chrNW_004936471:25,872,423...25,908,158 		JBrowse link
G Slc24a2 solute carrier family 24 member 2 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004936652:1,375,292...1,585,718
Ensembl chrNW_004936652:1,378,045...1,583,403 		JBrowse link
G Slc24a3 solute carrier family 24 member 3 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004936485:637,715...1,085,860
Ensembl chrNW_004936485:639,532...1,085,830 		JBrowse link
G Slc24a4 solute carrier family 24 member 4 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004936733:515,546...639,699
Ensembl chrNW_004936733:515,510...639,705 		JBrowse link
G Slc24a5 solute carrier family 24 member 5 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004936471:10,470,078...10,492,334
Ensembl chrNW_004936471:10,470,046...10,493,104 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004936508:10,894,918...11,256,084
Ensembl chrNW_004936508:10,968,656...11,253,070 		JBrowse link
G Slc8a2 solute carrier family 8 member A2 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004936664:1,116,543...1,139,586
Ensembl chrNW_004936664:1,116,491...1,139,586 		JBrowse link
G Slc8a3 solute carrier family 8 member A3 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004936495:13,236,480...13,370,973
Ensembl chrNW_004936495:13,236,470...13,371,011 		JBrowse link
G Slc8b1 solute carrier family 8 member B1 ISO RGD PMID:22850819 RGD:7204696 NCBI chrNW_004936668:3,160,148...3,181,814 JBrowse link
G Stim1 stromal interaction molecule 1 ISO RGD PMID:22914293 RGD:7204692 NCBI chrNW_004936498:849,775...1,063,552
Ensembl chrNW_004936498:849,739...1,063,552 		JBrowse link
G Stim2 stromal interaction molecule 2 ISO RGD PMID:22914293 RGD:7204692 NCBI chrNW_004936477:2,824,720...2,950,069
Ensembl chrNW_004936477:2,825,676...2,928,269 		JBrowse link
G Tpcn1 two pore segment channel 1 ISO RGD PMID:20018950 RGD:7204697 NCBI chrNW_004936668:3,111,038...3,162,163
Ensembl chrNW_004936668:3,111,002...3,163,396 		JBrowse link
G Tpcn2 two pore segment channel 2 ISO RGD PMID:20018950 RGD:7204697 NCBI chrNW_004936599:1,301,937...1,343,046
Ensembl chrNW_004936599:1,318,169...1,343,106 		JBrowse link
G Trpv5 transient receptor potential cation channel subfamily V member 5 ISO RGD PMID:20716668 RGD:7204689 NCBI chrNW_004936527:375,922...399,446
Ensembl chrNW_004936527:375,925...399,446 		JBrowse link
G Trpv6 transient receptor potential cation channel subfamily V member 6 ISO RGD PMID:20716668 RGD:7204689 NCBI chrNW_004936527:345,237...359,877
Ensembl chrNW_004936527:345,626...359,942 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3945
    regulatory pathway 2439
      transport pathway 291
        ion transport pathway 69
          metal ion transport pathway 69
            calcium transport pathway 55
Path 2
Term Annotations click to browse term
  pathway 3945
    regulatory pathway 2439
      homeostasis pathway 1275
        inorganic chemical homeostasis pathway 288
          metal homeostasis pathway 197
            calcium homeostasis pathway 136
              calcium transport pathway 55
paths to the root