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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:calcium transport pathway
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Accession:PW:0001139 term browser browse the term
Definition:Calcium is pumped into organelles or out of the cell by pumps and exchangers to maintain the low calcium concentration necessary for cell viability. Many type of channels, some calcium-selective, others of lower selectivity or calcium-permeant, allow for the flow of calcium from external sources or internal stores into the cell to initiate many signaling events. The movement of calcium ions, which controls and maintains the calcium gradient, and calcium signaling, which the gradient promotes, are inextricably connected in the fabric of calcium homeostasis.
Synonyms:related_synonym: calcium ion transport
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calcium transport pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 ISO RGD PMID:19789383 RGD:7204695 NCBI chr 3:18,545,064...18,568,312
Ensembl chr 3:18,545,071...18,568,310 		JBrowse link
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO RGD PMID:19789383 RGD:7204695 NCBI chr14:31,674,659...31,744,981
Ensembl chr14:31,674,757...31,744,969 		JBrowse link
G ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 ISO RGD PMID:19789383 RGD:7204695 NCBI chr12:49,980,488...50,014,006
Ensembl chr12:49,980,497...50,025,171 		JBrowse link
G ATP2B1 ATPase plasma membrane Ca2+ transporting 1 ISO RGD PMID:19789383 RGD:7204695 NCBI chr 5:92,935,688...93,061,406
Ensembl chr 5:92,935,694...93,061,405 		JBrowse link
G ATP2B2 ATPase plasma membrane Ca2+ transporting 2 ISO RGD PMID:19789383 RGD:7204695 NCBI chr13:66,526,508...66,897,125
Ensembl chr13:66,528,323...66,897,128 		JBrowse link
G ATP2B3 ATPase plasma membrane Ca2+ transporting 3 ISO RGD PMID:19789383 RGD:7204695 NCBI chr  X:124,318,874...124,357,653
Ensembl chr  X:124,301,713...124,357,653 		JBrowse link
G ATP2B4 ATPase plasma membrane Ca2+ transporting 4 ISO RGD PMID:19789383 RGD:7204695 NCBI chr 9:64,336,354...64,445,669
Ensembl chr 9:64,336,499...64,445,663 		JBrowse link
G ATP2C1 ATPase secretory pathway Ca2+ transporting 1 ISO RGD PMID:19789383 RGD:7204695 NCBI chr13:1,461,562...1,580,035
Ensembl chr13:1,438,615...1,612,676 		JBrowse link
G ATP2C2 ATPase secretory pathway Ca2+ transporting 2 ISO RGD PMID:19789383 RGD:7204695 NCBI chr 6:4,237,331...4,313,273
Ensembl chr 6:4,237,440...4,313,247 		JBrowse link
G CACNA1A calcium voltage-gated channel subunit alpha1 A ISO RGD PMID:21746798 RGD:7204688 NCBI chr 2:65,491,784...65,871,068
Ensembl chr 2:65,514,509...65,871,182 		JBrowse link
G CACNA1B calcium voltage-gated channel subunit alpha1 B ISO RGD PMID:21746798 RGD:7204688
G CACNA1C calcium voltage-gated channel subunit alpha1 C ISO RGD PMID:21746798 RGD:7204688 NCBI chr 5:69,016,954...69,448,428
Ensembl chr 5:69,275,176...69,454,459 		JBrowse link
G CACNA1D calcium voltage-gated channel subunit alpha1 D ISO RGD PMID:21746798 RGD:7204688 NCBI chr13:35,568,534...35,911,483
Ensembl chr13:35,436,519...35,909,662 		JBrowse link
G CACNA1E calcium voltage-gated channel subunit alpha1 E ISO RGD PMID:21746798 RGD:7204688 NCBI chr 9:122,827,386...123,318,372
Ensembl chr 9:123,006,195...123,315,319 		JBrowse link
G CACNA1F calcium voltage-gated channel subunit alpha1 F ISO RGD PMID:21746798 RGD:7204688 NCBI chr  X:43,250,449...43,284,458
Ensembl chr  X:43,251,370...43,283,990 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G ISO RGD PMID:21746798 RGD:7204688 NCBI chr12:26,838,633...26,912,344
Ensembl chr12:26,844,079...26,912,110 		JBrowse link
G CACNA1H calcium voltage-gated channel subunit alpha1 H ISO RGD PMID:21746798 RGD:7204688 NCBI chr 3:40,637,420...40,694,616
Ensembl chr 3:40,637,427...40,695,177 		JBrowse link
G CACNA1I calcium voltage-gated channel subunit alpha1 I ISO RGD PMID:21746798 RGD:7204688 NCBI chr 5:8,593,014...8,702,734
Ensembl chr 5:8,595,909...8,701,367 		JBrowse link
G CACNA1S calcium voltage-gated channel subunit alpha1 S ISO RGD PMID:21746798 RGD:7204688 NCBI chr10:23,503,701...23,567,797
Ensembl chr10:23,502,898...23,568,058 		JBrowse link
G CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 ISO RGD PMID:21746798 RGD:7204688 NCBI chr12:23,038,185...23,060,504
Ensembl chr12:23,037,810...23,060,490 		JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 ISO RGD PMID:21746798 RGD:7204688 NCBI chr10:44,321,954...44,887,410
Ensembl chr10:44,421,485...44,886,425 		JBrowse link
G CACNB3 calcium voltage-gated channel auxiliary subunit beta 3 ISO RGD PMID:21746798 RGD:7204688 NCBI chr 5:14,875,524...14,888,224
Ensembl chr 5:14,874,465...14,888,223 		JBrowse link
G CACNB4 calcium voltage-gated channel auxiliary subunit beta 4 ISO RGD PMID:21746798 RGD:7204688 NCBI chr15:402,801...455,691
Ensembl chr15:186,434...459,856 		JBrowse link
G CNGA1 cyclic nucleotide gated channel subunit alpha 1 ISO RGD PMID:12087135 RGD:6893549 NCBI chr 8:37,896,460...37,968,935
Ensembl chr 8:37,896,459...37,969,344 		JBrowse link
G CNGA2 cyclic nucleotide gated channel subunit alpha 2 ISO RGD PMID:12087135 RGD:6893549 NCBI chr  X:123,115,980...123,130,043
Ensembl chr  X:123,115,975...123,129,840 		JBrowse link
G CNGA3 cyclic nucleotide gated channel subunit alpha 3 ISO RGD PMID:12087135 RGD:6893549 NCBI chr 3:55,872,607...55,936,516
Ensembl chr 3:55,874,250...55,922,979 		JBrowse link
G CNGA4 cyclic nucleotide gated channel subunit alpha 4 ISO RGD PMID:12087135 RGD:6893549 NCBI chr 9:3,430,995...3,438,411
Ensembl chr 9:3,431,340...3,442,426 		JBrowse link
G CNGB1 cyclic nucleotide gated channel subunit beta 1 ISO RGD PMID:12087135 RGD:6893549 NCBI chr 6:19,752,734...19,865,830 JBrowse link
G CNGB3 cyclic nucleotide gated channel subunit beta 3 ISO RGD PMID:12087135 RGD:6893549 NCBI chr 4:50,112,927...50,263,264
Ensembl chr 4:50,112,927...50,263,222 		JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 ISO RGD PMID:19133301 RGD:7204693 NCBI chr13:61,068,131...61,398,918
Ensembl chr13:61,068,126...61,398,912 		JBrowse link
G ITPR2 inositol 1,4,5-trisphosphate receptor type 2 ISO RGD PMID:19133301 RGD:7204693 NCBI chr 5:46,935,923...47,465,681
Ensembl chr 5:46,935,932...47,464,125 		JBrowse link
G ITPR3 inositol 1,4,5-trisphosphate receptor type 3 ISO RGD PMID:19133301 RGD:7204693 NCBI chr 7:29,835,922...29,901,305
Ensembl chr 7:29,835,922...29,901,309 		JBrowse link
G MCOLN1 mucolipin TRP cation channel 1 ISO RGD PMID:20716668 RGD:7204689 NCBI chr 2:71,602,888...71,613,331
Ensembl chr 2:71,602,770...71,613,312 		JBrowse link
G MCU mitochondrial calcium uniporter ISO RGD PMID:22850819 RGD:7204696 NCBI chr14:75,518,533...75,721,502
Ensembl chr14:75,678,393...75,721,500 		JBrowse link
G ORAI1 ORAI calcium release-activated calcium modulator 1 ISO RGD PMID:22914293 RGD:7204692 NCBI chr14:31,012,212...31,028,008
Ensembl chr14:31,011,644...31,027,993 		JBrowse link
G ORAI2 ORAI calcium release-activated calcium modulator 2 ISO RGD PMID:22914293 RGD:7204692 NCBI chr 3:9,782,626...9,796,761
Ensembl chr 3:9,784,078...9,796,755 		JBrowse link
G ORAI3 ORAI calcium release-activated calcium modulator 3 ISO RGD PMID:22914293 RGD:7204692 NCBI chr 3:17,490,524...17,497,391
Ensembl chr 3:17,490,528...17,497,063 		JBrowse link
G RYR1 ryanodine receptor 1 ISO RGD PMID:20961976 RGD:7204694 NCBI chr 6:47,339,759...47,458,457
Ensembl chr 6:47,343,768...47,458,458 		JBrowse link
G RYR2 ryanodine receptor 2 ISO RGD PMID:20961976 RGD:7204694 NCBI chr14:53,652,140...54,406,691
Ensembl chr14:53,652,485...54,192,063 		JBrowse link
G RYR3 ryanodine receptor 3 ISO RGD PMID:20961976 RGD:7204694 NCBI chr 7:80,640,030...81,208,576
Ensembl chr 7:80,640,123...81,208,491 		JBrowse link
G SLC24A1 solute carrier family 24 member 1 ISO RGD PMID:17716241 RGD:7204698 NCBI chr 1:163,603,223...163,662,071
Ensembl chr 1:163,604,594...163,658,318 		JBrowse link
G SLC24A2 solute carrier family 24 member 2 ISO RGD PMID:17716241 RGD:7204698 NCBI chr 1:203,059,563...203,336,442
Ensembl chr 1:203,059,588...203,333,781 		JBrowse link
G SLC24A3 solute carrier family 24 member 3 ISO RGD PMID:17716241 RGD:7204698 NCBI chr17:27,270,232...27,780,535
Ensembl chr17:27,270,093...27,780,526 		JBrowse link
G SLC24A4 solute carrier family 24 member 4 ISO RGD PMID:17716241 RGD:7204698 NCBI chr 7:113,836,207...114,014,952
Ensembl chr 7:113,836,230...114,014,949 		JBrowse link
G SLC24A5 solute carrier family 24 member 5 ISO RGD PMID:17716241 RGD:7204698 NCBI chr 1:123,635,077...123,657,205
Ensembl chr 1:123,635,043...123,656,736 		JBrowse link
G SLC8A1 solute carrier family 8 member A1 ISO RGD PMID:17716241 RGD:7204698 NCBI chr 3:99,823,503...100,257,306
Ensembl chr 3:99,897,162...100,244,759 		JBrowse link
G SLC8A2 solute carrier family 8 member A2 ISO RGD PMID:17716241 RGD:7204698 NCBI chr 6:53,201,477...53,236,489
Ensembl chr 6:53,201,485...53,236,513 		JBrowse link
G SLC8A3 solute carrier family 8 member A3 ISO RGD PMID:17716241 RGD:7204698 NCBI chr 7:93,643,609...93,797,483
Ensembl chr 7:93,643,618...93,796,917 		JBrowse link
G SLC8B1 solute carrier family 8 member B1 ISO RGD PMID:22850819 RGD:7204696 NCBI chr14:38,773,396...38,808,261
Ensembl chr14:38,773,407...38,808,265 		JBrowse link
G STIM1 stromal interaction molecule 1 ISO RGD PMID:22914293 RGD:7204692 NCBI chr 9:6,066,612...6,270,090
Ensembl chr 9:6,066,617...6,270,575 		JBrowse link
G STIM2 stromal interaction molecule 2 ISO RGD PMID:22914293 RGD:7204692 NCBI chr 8:20,456,343...20,609,283
Ensembl chr 8:20,517,587...20,604,319 		JBrowse link
G TPCN1 two pore segment channel 1 ISO RGD PMID:20018950 RGD:7204697 NCBI chr14:38,698,680...38,773,189
Ensembl chr14:38,683,597...38,773,186 		JBrowse link
G TPCN2 two pore segment channel 2 ISO RGD PMID:20018950 RGD:7204697 NCBI chr 2:4,069,267...4,105,065
Ensembl chr 2:4,069,280...4,105,042 		JBrowse link
G TRPV5 transient receptor potential cation channel subfamily V member 5 ISO RGD PMID:20716668 RGD:7204689 NCBI chr18:7,285,186...7,341,965
Ensembl chr18:7,284,589...7,318,392 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4041
    regulatory pathway 2489
      transport pathway 293
        ion transport pathway 68
          metal ion transport pathway 68
            calcium transport pathway 54
Path 2
Term Annotations click to browse term
  pathway 4041
    regulatory pathway 2489
      homeostasis pathway 1301
        inorganic chemical homeostasis pathway 288
          metal homeostasis pathway 198
            calcium homeostasis pathway 137
              calcium transport pathway 54
paths to the root