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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:calcium transport pathway
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Accession:PW:0001139 term browser browse the term
Definition:Calcium is pumped into organelles or out of the cell by pumps and exchangers to maintain the low calcium concentration necessary for cell viability. Many type of channels, some calcium-selective, others of lower selectivity or calcium-permeant, allow for the flow of calcium from external sources or internal stores into the cell to initiate many signaling events. The movement of calcium ions, which controls and maintains the calcium gradient, and calcium signaling, which the gradient promotes, are inextricably connected in the fabric of calcium homeostasis.
Synonyms:related_synonym: calcium ion transport
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calcium transport pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004624782:12,867,404...12,883,685
Ensembl chrNW_004624782:12,867,230...12,883,685 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004624747:21,509,360...21,567,424
Ensembl chrNW_004624747:21,509,366...21,568,098 		JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004624786:6,528,177...6,558,576
Ensembl chrNW_004624786:6,528,182...6,558,547 		JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004624750:16,990,288...17,103,279 JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004624731:4,836,109...5,190,990
Ensembl chrNW_004624731:5,029,421...5,190,996 		JBrowse link
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004624946:247,032...307,645
Ensembl chrNW_004624946:247,168...307,663 		JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004624807:7,201,924...7,292,010
Ensembl chrNW_004624807:7,201,777...7,250,386 		JBrowse link
G Atp2c1 ATPase secretory pathway Ca2+ transporting 1 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004624730:6,865,197...7,001,378 JBrowse link
G Atp2c2 ATPase secretory pathway Ca2+ transporting 2 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004624746:1,399,368...1,445,999
Ensembl chrNW_004624746:1,413,813...1,445,646 		JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004624901:707,322...932,658
Ensembl chrNW_004624901:708,234...932,643 		JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004624760:78,754...257,901
Ensembl chrNW_004624760:81,236...257,787 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004624735:10,201,030...10,927,349
Ensembl chrNW_004624735:10,201,526...10,432,896 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004624822:3,391,045...3,734,258
Ensembl chrNW_004624822:3,392,044...3,919,415 		JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004624771:1,554,875...2,047,597
Ensembl chrNW_004624771:1,733,215...2,039,784 		JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004624893:945,378...968,041
Ensembl chrNW_004624893:945,436...970,431 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004624795:6,443,322...6,501,673
Ensembl chrNW_004624795:6,443,781...6,501,050 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004624913:1,926,405...1,952,426
Ensembl chrNW_004624913:1,891,156...1,949,633 		JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004624752:8,702,320...8,795,192
Ensembl chrNW_004624752:8,705,149...8,785,272 		JBrowse link
G Cacna1s calcium voltage-gated channel subunit alpha1 S ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004624807:9,560,004...9,618,942
Ensembl chrNW_004624807:9,559,954...9,619,132 		JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004624795:3,732,201...3,747,731
Ensembl chrNW_004624795:3,732,320...3,747,717 		JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004624796:9,502,132...9,858,836
Ensembl chrNW_004624796:9,503,452...9,859,019 		JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004624816:3,334,934...3,348,355
Ensembl chrNW_004624816:3,334,684...3,347,842 		JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004624866:4,973,087...5,287,477
Ensembl chrNW_004624866:4,973,207...5,281,746 		JBrowse link
G Cnga1 cyclic nucleotide gated channel subunit alpha 1 ISO RGD PMID:12087135 RGD:6893549 NCBI chrNW_004624761:18,992,372...19,004,247
Ensembl chrNW_004624761:18,992,384...19,004,202 		JBrowse link
G Cnga2 cyclic nucleotide gated channel subunit alpha 2 ISO RGD PMID:12087135 RGD:6893549 NCBI chrNW_004624883:3,043,661...3,051,420
Ensembl chrNW_004624883:3,043,666...3,049,801 		JBrowse link
G Cnga3 cyclic nucleotide gated channel subunit alpha 3 ISO RGD PMID:12087135 RGD:6893549 NCBI chrNW_004624749:3,458,997...3,482,697
Ensembl chrNW_004624749:3,458,991...3,483,003 		JBrowse link
G Cnga4 cyclic nucleotide gated channel subunit alpha 4 ISO RGD PMID:12087135 RGD:6893549 NCBI chrNW_004624817:7,716,951...7,732,177
Ensembl chrNW_004624817:7,719,332...7,737,336 		JBrowse link
G Cngb1 cyclic nucleotide gated channel subunit beta 1 ISO RGD PMID:12087135 RGD:6893549 NCBI chrNW_004624746:28,198,324...28,268,280 JBrowse link
G Cngb3 cyclic nucleotide gated channel subunit beta 3 ISO RGD PMID:12087135 RGD:6893549 NCBI chrNW_004624744:5,059,957...5,209,144
Ensembl chrNW_004624744:5,042,494...5,207,818 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor type 1 ISO RGD PMID:19133301 RGD:7204693 NCBI chrNW_004624773:14,856,803...15,193,173
Ensembl chrNW_004624773:14,856,804...15,193,168 		JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor type 2 ISO RGD PMID:19133301 RGD:7204693 NCBI chrNW_004624752:12,360,796...12,820,042
Ensembl chrNW_004624752:12,360,740...12,822,287 		JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor type 3 ISO RGD PMID:19133301 RGD:7204693 NCBI chrNW_004624754:23,228,690...23,281,552
Ensembl chrNW_004624754:23,229,281...23,281,621 		JBrowse link
G Mcoln1 mucolipin TRP cation channel 1 ISO RGD PMID:20716668 RGD:7204689 NCBI chrNW_004624828:634,318...643,406
Ensembl chrNW_004624828:634,214...643,633 		JBrowse link
G Mcu mitochondrial calcium uniporter ISO RGD PMID:22850819 RGD:7204696 NCBI chrNW_004624754:6,445,741...6,618,806 JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 ISO RGD PMID:22914293 RGD:7204692 NCBI chrNW_004624747:22,071,373...22,085,180
Ensembl chrNW_004624747:22,071,404...22,085,976 		JBrowse link
G Orai2 ORAI calcium release-activated calcium modulator 2 ISO RGD PMID:22914293 RGD:7204692 NCBI chrNW_004624740:15,189,533...15,201,059
Ensembl chrNW_004624740:15,189,533...15,201,073 		JBrowse link
G Orai3 ORAI calcium release-activated calcium modulator 3 ISO RGD PMID:22914293 RGD:7204692 NCBI chrNW_004624782:14,020,815...14,028,055
Ensembl chrNW_004624782:14,020,791...14,030,867 		JBrowse link
G Ryr1 ryanodine receptor 1 ISO RGD PMID:20961976 RGD:7204694 NCBI chrNW_004624794:11,888,211...12,004,457
Ensembl chrNW_004624794:11,888,289...12,004,314 		JBrowse link
G Ryr2 ryanodine receptor 2 ISO RGD PMID:20961976 RGD:7204694 NCBI chrNW_004624775:12,954,653...13,650,449
Ensembl chrNW_004624775:12,956,042...13,419,381 		JBrowse link
G Ryr3 ryanodine receptor 3 ISO RGD PMID:20961976 RGD:7204694 NCBI chrNW_004624804:467,207...1,030,873
Ensembl chrNW_004624804:467,295...1,030,212 		JBrowse link
G Slc24a1 solute carrier family 24 member 1 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004624781:6,934,108...6,957,632
Ensembl chrNW_004624781:6,935,239...6,974,196 		JBrowse link
G Slc24a2 solute carrier family 24 member 2 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004624736:23,488,228...23,735,657
Ensembl chrNW_004624736:23,496,268...23,733,259 		JBrowse link
G Slc24a3 solute carrier family 24 member 3 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004624741:19,808,186...20,298,772
Ensembl chrNW_004624741:19,808,255...20,297,056 		JBrowse link
G Slc24a4 solute carrier family 24 member 4 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004624734:8,911,376...9,069,054
Ensembl chrNW_004624734:8,911,455...9,063,063 		JBrowse link
G Slc24a5 solute carrier family 24 member 5 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004624731:11,552,865...11,573,987
Ensembl chrNW_004624731:11,552,969...11,574,044 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004624738:21,648,277...22,026,385
Ensembl chrNW_004624738:21,651,489...21,939,927 		JBrowse link
G Slc8a2 solute carrier family 8 member A2 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004624832:6,333,672...6,359,536
Ensembl chrNW_004624832:6,333,677...6,361,888 		JBrowse link
G Slc8a3 solute carrier family 8 member A3 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004624734:30,889,302...31,033,098
Ensembl chrNW_004624734:30,888,952...31,031,975 		JBrowse link
G Slc8b1 solute carrier family 8 member B1 ISO RGD PMID:22850819 RGD:7204696 NCBI chrNW_004624747:19,158,395...19,179,450
Ensembl chrNW_004624747:19,168,834...19,178,783 		JBrowse link
G Stim1 stromal interaction molecule 1 ISO RGD PMID:22914293 RGD:7204692 NCBI chrNW_004624817:5,291,111...5,522,732
Ensembl chrNW_004624817:5,291,717...5,522,864 		JBrowse link
G Stim2 stromal interaction molecule 2 ISO RGD PMID:22914293 RGD:7204692 NCBI chrNW_004624755:5,600,929...5,765,675
Ensembl chrNW_004624755:5,601,364...5,762,516 		JBrowse link
G Tpcn1 two pore segment channel 1 ISO RGD PMID:20018950 RGD:7204697 NCBI chrNW_004624747:19,179,378...19,237,799
Ensembl chrNW_004624747:19,179,575...19,236,206 		JBrowse link
G Tpcn2 two pore segment channel 2 ISO RGD PMID:20018950 RGD:7204697 NCBI chrNW_004624767:17,877,791...17,944,190
Ensembl chrNW_004624767:17,918,080...17,944,653 		JBrowse link
G Trpv6 transient receptor potential cation channel subfamily V member 6 ISO RGD PMID:20716668 RGD:7204689 NCBI chrNW_004624800:12,074,997...12,090,141
Ensembl chrNW_004624800:12,074,999...12,090,049 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3917
    regulatory pathway 2426
      transport pathway 290
        ion transport pathway 68
          metal ion transport pathway 68
            calcium transport pathway 54
Path 2
Term Annotations click to browse term
  pathway 3917
    regulatory pathway 2426
      homeostasis pathway 1267
        inorganic chemical homeostasis pathway 280
          metal homeostasis pathway 194
            calcium homeostasis pathway 134
              calcium transport pathway 54
paths to the root