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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:calcium transport pathway
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Accession:PW:0001139 term browser browse the term
Definition:Calcium is pumped into organelles or out of the cell by pumps and exchangers to maintain the low calcium concentration necessary for cell viability. Many type of channels, some calcium-selective, others of lower selectivity or calcium-permeant, allow for the flow of calcium from external sources or internal stores into the cell to initiate many signaling events. The movement of calcium ions, which controls and maintains the calcium gradient, and calcium signaling, which the gradient promotes, are inextricably connected in the fabric of calcium homeostasis.
Synonyms:related_synonym: calcium ion transport
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calcium transport pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 ISO RGD PMID:19789383 RGD:7204695 NCBI chr 7:126,045,032...126,062,245
Ensembl chr 7:126,045,030...126,062,280 		JBrowse link
G Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 ISO RGD PMID:19789383 RGD:7204695 NCBI chr 5:122,591,576...122,640,288
Ensembl chr 5:122,591,576...122,640,288 		JBrowse link
G Atp2a3 ATPase, Ca++ transporting, ubiquitous ISO RGD PMID:19789383 RGD:7204695 NCBI chr11:72,851,995...72,883,869
Ensembl chr11:72,851,995...72,883,870 		JBrowse link
G Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 ISO RGD PMID:19789383 RGD:7204695 NCBI chr10:98,750,243...98,862,005
Ensembl chr10:98,750,268...98,862,005 		JBrowse link
G Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 ISO RGD PMID:19789383 RGD:7204695 NCBI chr 6:113,720,803...114,019,574
Ensembl chr 6:113,720,792...114,019,574 		JBrowse link
G Atp2b3 ATPase, Ca++ transporting, plasma membrane 3 ISO RGD PMID:19789383 RGD:7204695 NCBI chr  X:72,546,356...72,632,267
Ensembl chr  X:72,546,692...72,614,611 		JBrowse link
G Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 ISO RGD PMID:19789383 RGD:7204695 NCBI chr 1:133,630,416...133,728,755
Ensembl chr 1:133,627,195...133,728,779 		JBrowse link
G Atp2c1 ATPase, Ca++-sequestering ISO RGD PMID:19789383 RGD:7204695 NCBI chr 9:105,288,561...105,398,456
Ensembl chr 9:105,280,738...105,404,518 		JBrowse link
G Atp2c2 ATPase, Ca++ transporting, type 2C, member 2 ISO RGD PMID:19789383 RGD:7204695 NCBI chr 8:120,426,748...120,484,457
Ensembl chr 8:120,426,748...120,484,456 		JBrowse link
G Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit ISO RGD PMID:21746798 RGD:7204688 NCBI chr 8:85,065,257...85,366,880
Ensembl chr 8:85,065,268...85,366,875 		JBrowse link
G Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit ISO RGD PMID:21746798 RGD:7204688 NCBI chr 2:24,493,872...24,653,210
Ensembl chr 2:24,493,899...24,653,164 		JBrowse link
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit ISO RGD PMID:21746798 RGD:7204688 NCBI chr 6:118,564,201...119,174,345
Ensembl chr 6:118,564,201...119,173,851 		JBrowse link
G Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit ISO RGD PMID:21746798 RGD:7204688 NCBI chr14:29,761,898...30,213,113
Ensembl chr14:29,761,896...30,213,412 		JBrowse link
G Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit ISO RGD PMID:21746798 RGD:7204688 NCBI chr 1:154,266,552...154,760,374
Ensembl chr 1:154,266,477...154,760,247 		JBrowse link
G Cacna1f calcium channel, voltage-dependent, alpha 1F subunit ISO RGD PMID:21746798 RGD:7204688 NCBI chr  X:7,473,342...7,501,435
Ensembl chr  X:7,473,322...7,501,435 		JBrowse link
G Cacna1g calcium channel, voltage-dependent, T type, alpha 1G subunit ISO RGD PMID:21746798 RGD:7204688 NCBI chr11:94,299,217...94,365,226
Ensembl chr11:94,299,217...94,365,024 		JBrowse link
G Cacna1h calcium channel, voltage-dependent, T type, alpha 1H subunit ISO RGD PMID:21746798 RGD:7204688 NCBI chr17:25,593,259...25,655,308
Ensembl chr17:25,593,259...25,652,759 		JBrowse link
G Cacna1i calcium channel, voltage-dependent, alpha 1I subunit ISO RGD PMID:21746798 RGD:7204688 NCBI chr15:80,171,439...80,282,493
Ensembl chr15:80,171,439...80,282,480 		JBrowse link
G Cacna1s calcium channel, voltage-dependent, L type, alpha 1S subunit ISO RGD PMID:21746798 RGD:7204688 NCBI chr 1:135,980,549...136,047,268
Ensembl chr 1:135,980,488...136,047,560 		JBrowse link
G Cacnb1 calcium channel, voltage-dependent, beta 1 subunit ISO RGD PMID:21746798 RGD:7204688 NCBI chr11:97,892,339...97,913,860
Ensembl chr11:97,892,334...97,913,860 		JBrowse link
G Cacnb2 calcium channel, voltage-dependent, beta 2 subunit ISO RGD PMID:21746798 RGD:7204688 NCBI chr 2:14,608,672...14,993,622
Ensembl chr 2:14,607,899...14,992,719 		JBrowse link
G Cacnb3 calcium channel, voltage-dependent, beta 3 subunit ISO RGD PMID:21746798 RGD:7204688 NCBI chr15:98,526,317...98,542,410
Ensembl chr15:98,528,721...98,542,410 		JBrowse link
G Cacnb4 calcium channel, voltage-dependent, beta 4 subunit ISO RGD PMID:21746798 RGD:7204688 NCBI chr 2:52,318,332...52,566,816
Ensembl chr 2:52,318,337...52,566,843 		JBrowse link
G Cnga1 cyclic nucleotide gated channel alpha 1 ISO RGD PMID:12087135 RGD:6893549 NCBI chr 5:72,761,039...72,800,095
Ensembl chr 5:72,761,039...72,801,618 		JBrowse link
G Cnga2 cyclic nucleotide gated channel alpha 2 ISO RGD PMID:12087135 RGD:6893549 NCBI chr  X:71,035,455...71,053,824
Ensembl chr  X:71,035,455...71,053,824 		JBrowse link
G Cnga3 cyclic nucleotide gated channel alpha 3 ISO RGD PMID:12087135 RGD:6893549 NCBI chr 1:37,257,317...37,302,465
Ensembl chr 1:37,253,515...37,302,465 		JBrowse link
G Cnga4 cyclic nucleotide gated channel alpha 4 ISO RGD PMID:12087135 RGD:6893549 NCBI chr 7:105,049,247...105,057,981
Ensembl chr 7:105,053,775...105,057,949 		JBrowse link
G Cngb1 cyclic nucleotide gated channel beta 1 ISO RGD PMID:12087135 RGD:6893549 NCBI chr 8:95,965,671...96,033,213
Ensembl chr 8:95,965,673...96,033,213 		JBrowse link
G Cngb3 cyclic nucleotide gated channel beta 3 TAS RGD PMID:12087135 RGD:6893549 NCBI chr 4:19,280,850...19,510,623
Ensembl chr 4:19,280,850...19,510,623 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor 1 ISO RGD PMID:19133301 RGD:7204693 NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070 		JBrowse link
G Itpr2 inositol 1,4,5-triphosphate receptor 2 ISO RGD PMID:19133301 RGD:7204693 NCBI chr 6:146,009,797...146,403,757
Ensembl chr 6:146,009,797...146,403,721 		JBrowse link
G Itpr3 inositol 1,4,5-triphosphate receptor 3 ISO RGD PMID:19133301 RGD:7204693 NCBI chr17:27,275,976...27,341,197
Ensembl chr17:27,276,278...27,341,197 		JBrowse link
G Mcoln1 mucolipin 1 ISO RGD PMID:20716668 RGD:7204689 NCBI chr 8:3,550,458...3,565,232
Ensembl chr 8:3,550,457...3,565,232 		JBrowse link
G Mcu mitochondrial calcium uniporter ISO RGD PMID:22850819 RGD:7204696 NCBI chr10:59,282,806...59,453,231
Ensembl chr10:59,282,806...59,452,514 		JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 ISO RGD PMID:22914293 RGD:7204692 NCBI chr 5:123,153,078...123,168,515
Ensembl chr 5:123,153,137...123,168,519 		JBrowse link
G Orai2 ORAI calcium release-activated calcium modulator 2 ISO RGD PMID:22914293 RGD:7204692 NCBI chr 5:136,176,310...136,201,418
Ensembl chr 5:136,176,313...136,199,567 		JBrowse link
G Orai3 ORAI calcium release-activated calcium modulator 3 ISO RGD PMID:22914293 RGD:7204692 NCBI chr 7:127,368,987...127,374,322
Ensembl chr 7:127,368,987...127,374,322 		JBrowse link
G Ryr1 ryanodine receptor 1, skeletal muscle ISO RGD PMID:20961976 RGD:7204694 NCBI chr 7:28,702,765...28,824,599
Ensembl chr 7:28,702,769...28,824,604 		JBrowse link
G Ryr2 ryanodine receptor 2, cardiac ISO RGD PMID:20961976 RGD:7204694 NCBI chr13:11,567,985...12,121,831
Ensembl chr13:11,567,988...12,121,831 		JBrowse link
G Ryr3 ryanodine receptor 3 ISO RGD PMID:20961976 RGD:7204694 NCBI chr 2:112,461,699...113,047,755
Ensembl chr 2:112,461,700...113,047,441 		JBrowse link
G Slc24a1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 ISO RGD PMID:17716241 RGD:7204698 NCBI chr 9:64,830,143...64,858,902
Ensembl chr 9:64,830,143...64,858,889 		JBrowse link
G Slc24a2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 ISO RGD PMID:17716241 RGD:7204698 NCBI chr 4:86,901,361...87,148,780
Ensembl chr 4:86,901,361...87,148,714 		JBrowse link
G Slc24a3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 ISO RGD PMID:17716241 RGD:7204698 NCBI chr 2:145,009,695...145,484,086
Ensembl chr 2:145,009,674...145,484,086 		JBrowse link
G Slc24a4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 ISO RGD PMID:17716241 RGD:7204698 NCBI chr12:102,094,986...102,239,562
Ensembl chr12:102,094,992...102,233,350 		JBrowse link
G Slc24a5 solute carrier family 24, member 5 ISO RGD PMID:17716241 RGD:7204698 NCBI chr 2:124,910,076...124,930,316
Ensembl chr 2:124,910,044...124,930,597 		JBrowse link
G Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 ISO RGD PMID:17716241 RGD:7204698 NCBI chr17:81,680,534...82,045,816
Ensembl chr17:81,680,534...82,045,806 		JBrowse link
G Slc8a2 solute carrier family 8 (sodium/calcium exchanger), member 2 ISO RGD PMID:17716241 RGD:7204698 NCBI chr 7:15,861,540...15,894,988
Ensembl chr 7:15,863,751...15,894,988 		JBrowse link
G Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 ISO RGD PMID:17716241 RGD:7204698 NCBI chr12:81,244,686...81,380,506
Ensembl chr12:81,244,689...81,379,954 		JBrowse link
G Slc8b1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 ISO RGD PMID:22850819 RGD:7204696 NCBI chr 5:120,649,233...120,672,089
Ensembl chr 5:120,649,233...120,672,089 		JBrowse link
G Stim1 stromal interaction molecule 1 ISO RGD PMID:22914293 RGD:7204692 NCBI chr 7:101,909,279...102,086,525
Ensembl chr 7:101,917,013...102,086,526 		JBrowse link
G Stim2 stromal interaction molecule 2 ISO RGD PMID:22914293 RGD:7204692 NCBI chr 5:54,155,865...54,278,399
Ensembl chr 5:54,155,841...54,278,399 		JBrowse link
G Tpcn1 two pore channel 1 ISO RGD PMID:20018950 RGD:7204697 NCBI chr 5:120,672,222...120,726,731
Ensembl chr 5:120,672,218...120,726,738 		JBrowse link
G Tpcn2 two pore segment channel 2 ISO RGD PMID:20018950 RGD:7204697 NCBI chr 7:144,735,370...144,837,743
Ensembl chr 7:144,740,261...144,837,748 		JBrowse link
G Trpv5 transient receptor potential cation channel, subfamily V, member 5 ISO RGD PMID:20716668 RGD:7204689 NCBI chr 6:41,628,595...41,658,158
Ensembl chr 6:41,629,107...41,657,703 		JBrowse link
G Trpv6 transient receptor potential cation channel, subfamily V, member 6 ISO RGD PMID:20716668 RGD:7204689 NCBI chr 6:41,597,553...41,613,339
Ensembl chr 6:41,597,558...41,613,339 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6074
    regulatory pathway 3686
      transport pathway 357
        ion transport pathway 69
          metal ion transport pathway 69
            calcium transport pathway 55
Path 2
Term Annotations click to browse term
  pathway 6074
    regulatory pathway 3686
      homeostasis pathway 1721
        inorganic chemical homeostasis pathway 294
          metal homeostasis pathway 202
            calcium homeostasis pathway 140
              calcium transport pathway 55
paths to the root