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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:calcium transport pathway
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Accession:PW:0001139 term browser browse the term
Definition:Calcium is pumped into organelles or out of the cell by pumps and exchangers to maintain the low calcium concentration necessary for cell viability. Many type of channels, some calcium-selective, others of lower selectivity or calcium-permeant, allow for the flow of calcium from external sources or internal stores into the cell to initiate many signaling events. The movement of calcium ions, which controls and maintains the calcium gradient, and calcium signaling, which the gradient promotes, are inextricably connected in the fabric of calcium homeostasis.
Synonyms:related_synonym: calcium ion transport
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calcium transport pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 ISO RGD PMID:19789383 RGD:7204695 NCBI chr 5:26,165,370...26,196,517
Ensembl chr 5:26,164,205...26,193,172 		JBrowse link
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO RGD PMID:19789383 RGD:7204695 NCBI chr11:105,522,175...105,590,291
Ensembl chr11:105,522,157...105,590,958 		JBrowse link
G ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 ISO RGD PMID:19789383 RGD:7204695 NCBI chr16:3,405,871...3,443,339
Ensembl chr16:3,405,820...3,443,275 		JBrowse link
G ATP2B1 ATPase plasma membrane Ca2+ transporting 1 ISO RGD PMID:19789383 RGD:7204695 NCBI chr11:84,985,957...85,053,923
Ensembl chr11:84,989,169...85,103,957 		JBrowse link
G ATP2B2 ATPase plasma membrane Ca2+ transporting 2 ISO RGD PMID:19789383 RGD:7204695 NCBI chr22:46,360,306...46,742,446
Ensembl chr22:46,368,243...46,662,220 		JBrowse link
G ATP2B3 ATPase plasma membrane Ca2+ transporting 3 ISO RGD PMID:19789383 RGD:7204695 NCBI chr  X:127,966,366...128,013,900
Ensembl chr  X:127,966,492...128,013,901 		JBrowse link
G ATP2B4 ATPase plasma membrane Ca2+ transporting 4 ISO RGD PMID:19789383 RGD:7204695 NCBI chr25:25,602,857...25,716,385
Ensembl chr25:25,602,715...25,661,553 		JBrowse link
G ATP2C1 ATPase secretory pathway Ca2+ transporting 1 ISO RGD PMID:19789383 RGD:7204695 NCBI chr15:59,189,075...59,348,684
Ensembl chr15:59,188,225...59,311,709 		JBrowse link
G ATP2C2 ATPase secretory pathway Ca2+ transporting 2 ISO RGD PMID:19789383 RGD:7204695 NCBI chr 5:69,771,909...69,861,030
Ensembl chr 5:69,801,818...69,860,576 		JBrowse link
G CACNA1A calcium voltage-gated channel subunit alpha1 A ISO RGD PMID:21746798 RGD:7204688 NCBI chr 6:11,883,353...12,307,023 JBrowse link
G CACNA1B calcium voltage-gated channel subunit alpha1 B ISO RGD PMID:21746798 RGD:7204688 NCBI chr12:75,441...335,980
Ensembl chr12:78,011...335,820 		JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C ISO RGD PMID:21746798 RGD:7204688 NCBI chr11:2,107,722...2,753,970
Ensembl chr11:2,508,705...2,752,991 		JBrowse link
G CACNA1D calcium voltage-gated channel subunit alpha1 D ISO RGD PMID:21746798 RGD:7204688 NCBI chr22:14,868,459...15,195,002
Ensembl chr22:15,027,565...15,197,101 		JBrowse link
G CACNA1E calcium voltage-gated channel subunit alpha1 E ISO RGD PMID:21746798 RGD:7204688 NCBI chr25:47,589,859...47,924,081
Ensembl chr25:47,597,808...47,922,969 		JBrowse link
G CACNA1F calcium voltage-gated channel subunit alpha1 F ISO RGD PMID:21746798 RGD:7204688 NCBI chr  X:46,304,831...46,330,562 JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G ISO RGD PMID:21746798 RGD:7204688 NCBI chr16:42,710,640...42,776,736
Ensembl chr16:42,708,638...42,768,843 		JBrowse link
G CACNA1H calcium voltage-gated channel subunit alpha1 H ISO RGD PMID:21746798 RGD:7204688 NCBI chr 5:1,039,709...1,106,212
Ensembl chr 5:1,078,973...1,106,507 		JBrowse link
G CACNA1I calcium voltage-gated channel subunit alpha1 I ISO RGD PMID:21746798 RGD:7204688 NCBI chr19:22,129,795...22,264,485
Ensembl chr19:22,143,980...22,261,098 		JBrowse link
G CACNA1S calcium voltage-gated channel subunit alpha1 S ISO RGD PMID:21746798 RGD:7204688 NCBI chr25:28,288,483...28,363,231
Ensembl chr25:28,289,342...28,363,327 		JBrowse link
G CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 ISO RGD PMID:21746798 RGD:7204688 NCBI chr16:66,971,379...66,994,031
Ensembl chr16:66,971,459...66,996,095 		JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 ISO RGD PMID:21746798 RGD:7204688 NCBI chr 9:18,075,436...18,470,985
Ensembl chr 9:18,332,165...18,469,617 		JBrowse link
G CACNB3 calcium voltage-gated channel auxiliary subunit beta 3 ISO RGD PMID:21746798 RGD:7204688 NCBI chr11:45,056,116...45,071,076
Ensembl chr11:45,061,046...45,071,544 		JBrowse link
G CACNB4 calcium voltage-gated channel auxiliary subunit beta 4 ISO RGD PMID:21746798 RGD:7204688 NCBI chr10:37,240,749...37,518,174
Ensembl chr10:37,246,991...37,388,059 		JBrowse link
G CNGA2 cyclic nucleotide gated channel subunit alpha 2 ISO RGD PMID:12087135 RGD:6893549 NCBI chr  X:126,277,931...126,302,167
Ensembl chr  X:126,295,236...126,301,141 		JBrowse link
G CNGA3 cyclic nucleotide gated channel subunit alpha 3 ISO RGD PMID:12087135 RGD:6893549 NCBI chr14:2,039,281...2,124,527
Ensembl chr14:2,096,232...2,123,231 		JBrowse link
G CNGA4 cyclic nucleotide gated channel subunit alpha 4 ISO RGD PMID:12087135 RGD:6893549 NCBI chr 1:58,581,702...58,592,733
Ensembl chr 1:58,582,175...58,588,376 		JBrowse link
G CNGB1 cyclic nucleotide gated channel subunit beta 1 ISO RGD PMID:12087135 RGD:6893549 NCBI chr 5:43,814,500...43,903,323 JBrowse link
G CNGB3 cyclic nucleotide gated channel subunit beta 3 ISO RGD PMID:12087135 RGD:6893549 NCBI chr 8:81,757,567...81,911,256
Ensembl chr 8:81,759,642...81,909,760 		JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 ISO RGD PMID:19133301 RGD:7204693 NCBI chr22:40,574,569...40,925,857
Ensembl chr22:40,574,374...40,926,842 		JBrowse link
G ITPR2 inositol 1,4,5-trisphosphate receptor type 2 ISO RGD PMID:19133301 RGD:7204693 NCBI chr11:26,089,480...26,574,621
Ensembl chr11:26,089,484...26,574,950 		JBrowse link
G ITPR3 inositol 1,4,5-trisphosphate receptor type 3 ISO RGD PMID:19133301 RGD:7204693 NCBI chr17:38,381,862...38,456,505
Ensembl chr17:38,381,743...38,456,499 		JBrowse link
G LOC103246137 cyclic nucleotide gated channel subunit alpha 1 ISO RGD PMID:12087135 RGD:6893549 NCBI chr27:2,273,540...2,313,083
Ensembl chr27:2,293,765...2,312,761 		JBrowse link
G MCOLN1 mucolipin TRP cation channel 1 ISO RGD PMID:20716668 RGD:7204689 NCBI chr 6:7,019,132...7,030,675
Ensembl chr 6:7,019,277...7,030,474 		JBrowse link
G MCU mitochondrial calcium uniporter ISO RGD PMID:22850819 RGD:7204696 NCBI chr 9:58,383,650...58,594,542
Ensembl chr 9:58,383,235...58,571,480 		JBrowse link
G ORAI1 ORAI calcium release-activated calcium modulator 1 ISO RGD PMID:22914293 RGD:7204692 NCBI chr11:116,997,375...117,012,115
Ensembl chr11:116,997,636...117,011,737 		JBrowse link
G ORAI2 ORAI calcium release-activated calcium modulator 2 ISO RGD PMID:22914293 RGD:7204692 NCBI chr28:10,775,456...10,788,670
Ensembl chr28:10,775,474...10,788,634 		JBrowse link
G ORAI3 ORAI calcium release-activated calcium modulator 3 ISO RGD PMID:22914293 RGD:7204692 NCBI chr 5:27,637,919...27,644,585
Ensembl chr 5:27,638,731...27,644,829 		JBrowse link
G RYR1 ryanodine receptor 1 ISO RGD PMID:20961976 RGD:7204694 NCBI chr 6:33,080,443...33,234,478
Ensembl chr 6:33,080,758...33,213,788 		JBrowse link
G RYR2 ryanodine receptor 2 ISO RGD PMID:20961976 RGD:7204694 NCBI chr25:74,169,024...74,951,371
Ensembl chr25:74,389,122...74,953,451 		JBrowse link
G SLC24A1 solute carrier family 24 member 1 ISO RGD PMID:17716241 RGD:7204698 NCBI chr26:17,924,872...17,969,413
Ensembl chr26:17,923,872...17,956,668 		JBrowse link
G SLC24A2 solute carrier family 24 member 2 ISO RGD PMID:17716241 RGD:7204698 NCBI chr12:59,962,744...60,229,539
Ensembl chr12:59,964,749...60,224,816 		JBrowse link
G SLC24A3 solute carrier family 24 member 3 ISO RGD PMID:17716241 RGD:7204698 NCBI chr 2:48,238,872...48,736,517 JBrowse link
G SLC24A4 solute carrier family 24 member 4 ISO RGD PMID:17716241 RGD:7204698 NCBI chr24:70,068,924...70,242,148
Ensembl chr24:70,179,850...70,239,517 		JBrowse link
G SLC24A5 solute carrier family 24 member 5 ISO RGD PMID:17716241 RGD:7204698 NCBI chr26:35,143,004...35,164,134
Ensembl chr26:35,143,097...35,163,718 		JBrowse link
G SLC8A1 solute carrier family 8 member A1 ISO RGD PMID:17716241 RGD:7204698 NCBI chr14:66,813,523...67,210,261 JBrowse link
G SLC8A2 solute carrier family 8 member A2 ISO RGD PMID:17716241 RGD:7204698 NCBI chr 6:40,758,106...40,803,277
Ensembl chr 6:40,757,440...40,797,126 		JBrowse link
G SLC8A3 solute carrier family 8 member A3 ISO RGD PMID:17716241 RGD:7204698 NCBI chr24:47,287,487...47,428,608
Ensembl chr24:47,288,256...47,427,776 		JBrowse link
G SLC8B1 solute carrier family 8 member B1 ISO RGD PMID:22850819 RGD:7204696 NCBI chr11:108,553,545...108,590,017
Ensembl chr11:108,553,794...108,589,533 		JBrowse link
G STIM1 stromal interaction molecule 1 ISO RGD PMID:22914293 RGD:7204692 NCBI chr 1:62,651,472...62,865,992
Ensembl chr 1:62,651,290...62,865,986 		JBrowse link
G STIM2 stromal interaction molecule 2 ISO RGD PMID:22914293 RGD:7204692 NCBI chr27:23,330,382...23,498,965
Ensembl chr27:23,332,789...23,498,829 		JBrowse link
G TPCN1 two pore segment channel 1 ISO RGD PMID:20018950 RGD:7204697 NCBI chr11:108,459,754...108,549,933
Ensembl chr11:108,475,380...108,552,374 		JBrowse link
G TPCN2 two pore segment channel 2 ISO RGD PMID:20018950 RGD:7204697 NCBI chr 1:5,491,476...5,529,015
Ensembl chr 1:5,490,910...5,528,718 		JBrowse link
G TRPV5 transient receptor potential cation channel subfamily V member 5 ISO RGD PMID:20716668 RGD:7204689 NCBI chr21:111,787,214...111,816,893
Ensembl chr21:111,787,694...111,811,847 		JBrowse link
G TRPV6 transient receptor potential cation channel subfamily V member 6 ISO RGD PMID:20716668 RGD:7204689 NCBI chr21:111,750,821...111,766,274
Ensembl chr21:111,750,945...111,765,450 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4028
    regulatory pathway 2488
      transport pathway 294
        ion transport pathway 67
          metal ion transport pathway 67
            calcium transport pathway 54
Path 2
Term Annotations click to browse term
  pathway 4028
    regulatory pathway 2488
      homeostasis pathway 1295
        inorganic chemical homeostasis pathway 287
          metal homeostasis pathway 197
            calcium homeostasis pathway 137
              calcium transport pathway 54
paths to the root