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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:calcium transport pathway
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Accession:PW:0001139 term browser browse the term
Definition:Calcium is pumped into organelles or out of the cell by pumps and exchangers to maintain the low calcium concentration necessary for cell viability. Many type of channels, some calcium-selective, others of lower selectivity or calcium-permeant, allow for the flow of calcium from external sources or internal stores into the cell to initiate many signaling events. The movement of calcium ions, which controls and maintains the calcium gradient, and calcium signaling, which the gradient promotes, are inextricably connected in the fabric of calcium homeostasis.
Synonyms:related_synonym: calcium ion transport
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calcium transport pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004955493:6,559,995...6,578,461
Ensembl chrNW_004955493:6,559,995...6,578,461 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004955482:7,233,336...7,295,754
Ensembl chrNW_004955482:7,233,336...7,295,754 		JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004955467:12,911,679...12,941,322
Ensembl chrNW_004955467:12,911,679...12,941,924 		JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004955405:26,872,379...26,932,270
Ensembl chrNW_004955405:26,872,379...26,932,703 		JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004955561:1,727,935...1,851,907
Ensembl chrNW_004955561:1,727,935...1,851,907 		JBrowse link
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004955580:286,092...332,657
Ensembl chrNW_004955580:269,100...333,471 		JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004955406:39,552,034...39,645,694
Ensembl chrNW_004955406:39,552,019...39,645,694 		JBrowse link
G Atp2c1 ATPase secretory pathway Ca2+ transporting 1 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004955501:7,382,657...7,519,789
Ensembl chrNW_004955501:7,383,150...7,519,988 		JBrowse link
G Atp2c2 ATPase secretory pathway Ca2+ transporting 2 ISO RGD PMID:19789383 RGD:7204695 NCBI chrNW_004955541:47,803...95,074
Ensembl chrNW_004955541:47,768...94,878 		JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004955415:32,182,536...32,457,511
Ensembl chrNW_004955415:32,183,442...32,400,595 		JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004955513:5,654,915...5,823,094
Ensembl chrNW_004955513:5,654,238...5,824,386 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004955454:4,573,647...5,199,046
Ensembl chrNW_004955454:4,490,923...5,198,506 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004955430:3,450,151...3,796,983
Ensembl chrNW_004955430:3,268,953...3,794,592 		JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004955406:20,356,564...20,824,679
Ensembl chrNW_004955406:20,510,954...20,816,678 		JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004955543:692,035...717,364
Ensembl chrNW_004955543:692,035...717,364 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004955451:11,136,885...11,194,321
Ensembl chrNW_004955451:11,137,214...11,194,036 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004955442:16,047,965...16,108,862
Ensembl chrNW_004955442:16,045,895...16,108,862 		JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004955413:25,440,533...25,538,367
Ensembl chrNW_004955413:25,453,703...25,535,530 		JBrowse link
G Cacna1s calcium voltage-gated channel subunit alpha1 S ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004955406:37,201,180...37,263,328
Ensembl chrNW_004955406:37,201,180...37,263,371 		JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004955451:14,041,848...14,059,740
Ensembl chrNW_004955451:14,038,668...14,059,848 		JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004955429:9,642,725...9,966,175
Ensembl chrNW_004955429:9,644,053...9,966,175 		JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004955500:7,676,331...7,685,174
Ensembl chrNW_004955500:7,672,828...7,687,420 		JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 ISO RGD PMID:21746798 RGD:7204688 NCBI chrNW_004955440:17,364,996...17,497,446
Ensembl chrNW_004955440:17,371,321...17,497,616 		JBrowse link
G Cnga1 cyclic nucleotide gated channel subunit alpha 1 ISO RGD PMID:12087135 RGD:6893549 NCBI chrNW_004955443:615,061...649,693
Ensembl chrNW_004955443:639,096...649,606 		JBrowse link
G Cnga2 cyclic nucleotide gated channel subunit alpha 2 ISO RGD PMID:12087135 RGD:6893549 NCBI chrNW_004955498:7,250,514...7,257,701
Ensembl chrNW_004955498:7,250,514...7,257,701 		JBrowse link
G Cnga3 cyclic nucleotide gated channel subunit alpha 3 ISO RGD PMID:12087135 RGD:6893549 NCBI chrNW_004955470:4,884,054...4,907,151
Ensembl chrNW_004955470:4,884,309...4,906,902 		JBrowse link
G Cnga4 cyclic nucleotide gated channel subunit alpha 4 ISO RGD PMID:12087135 RGD:6893549 NCBI chrNW_004955414:21,977,996...21,986,349
Ensembl chrNW_004955414:21,977,996...21,986,441 		JBrowse link
G Cngb1 cyclic nucleotide gated channel subunit beta 1 ISO RGD PMID:12087135 RGD:6893549 NCBI chrNW_004955433:15,467,042...15,556,471 JBrowse link
G Cngb3 cyclic nucleotide gated channel subunit beta 3 ISO RGD PMID:12087135 RGD:6893549 NCBI chrNW_004955417:4,164,328...4,288,516
Ensembl chrNW_004955417:4,168,766...4,300,437 		JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor type 2 ISO RGD PMID:19133301 RGD:7204693 NCBI chrNW_004955413:21,289,673...21,719,610
Ensembl chrNW_004955413:21,291,110...21,719,303 		JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor type 3 ISO RGD PMID:19133301 RGD:7204693 NCBI chrNW_004955437:2,055,782...2,106,709
Ensembl chrNW_004955437:2,055,805...2,106,076 		JBrowse link
G Mcoln1 mucolipin TRP cation channel 1 ISO RGD PMID:20716668 RGD:7204689 NCBI chrNW_004955563:1,703,408...1,712,908
Ensembl chrNW_004955563:1,703,416...1,745,996 		JBrowse link
G Mcu mitochondrial calcium uniporter ISO RGD PMID:22850819 RGD:7204696 NCBI chrNW_004955437:18,750,779...18,800,149
Ensembl chrNW_004955437:18,752,584...18,936,507 		JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 ISO RGD PMID:22914293 RGD:7204692 NCBI chrNW_004955482:6,731,949...6,746,095
Ensembl chrNW_004955482:6,731,949...6,775,545 		JBrowse link
G Orai2 ORAI calcium release-activated calcium modulator 2 ISO RGD PMID:22914293 RGD:7204692 NCBI chrNW_004955456:15,170,424...15,180,763
Ensembl chrNW_004955456:15,170,424...15,180,763 		JBrowse link
G Orai3 ORAI calcium release-activated calcium modulator 3 ISO RGD PMID:22914293 RGD:7204692 NCBI chrNW_004955493:7,799,738...7,806,590
Ensembl chrNW_004955493:7,799,738...7,806,590 		JBrowse link
G Ryr1 ryanodine receptor 1 ISO RGD PMID:20961976 RGD:7204694 NCBI chrNW_004955468:879,807...1,000,118
Ensembl chrNW_004955468:879,951...1,000,036 		JBrowse link
G Ryr2 ryanodine receptor 2 ISO RGD PMID:20961976 RGD:7204694 NCBI chrNW_004955492:2,647,597...3,275,512
Ensembl chrNW_004955492:2,648,956...3,076,509 		JBrowse link
G Ryr3 ryanodine receptor 3 ISO RGD PMID:20961976 RGD:7204694 NCBI chrNW_004955416:712,506...1,260,111
Ensembl chrNW_004955416:713,373...1,259,885 		JBrowse link
G Slc24a1 solute carrier family 24 member 1 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004955450:9,850,170...9,881,172
Ensembl chrNW_004955450:9,856,718...9,881,172 		JBrowse link
G Slc24a2 solute carrier family 24 member 2 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004955434:21,871,319...22,091,125
Ensembl chrNW_004955434:21,873,091...22,091,177 		JBrowse link
G Slc24a3 solute carrier family 24 member 3 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004955415:27,477,801...27,930,108
Ensembl chrNW_004955415:27,477,819...27,928,383 		JBrowse link
G Slc24a4 solute carrier family 24 member 4 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004955438:14,609,779...14,765,516
Ensembl chrNW_004955438:14,609,424...14,759,673 		JBrowse link
G Slc24a5 solute carrier family 24 member 5 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004955409:5,747,624...5,768,122
Ensembl chrNW_004955409:5,747,624...5,768,122 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004955441:7,653,107...8,037,784
Ensembl chrNW_004955441:7,656,031...7,957,640 		JBrowse link
G Slc8a2 solute carrier family 8 member A2 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004955574:1,290,907...1,315,399
Ensembl chrNW_004955574:1,288,952...1,315,401 		JBrowse link
G Slc8a3 solute carrier family 8 member A3 ISO RGD PMID:17716241 RGD:7204698 NCBI chrNW_004955466:220,346...359,627
Ensembl chrNW_004955466:220,099...360,851 		JBrowse link
G Slc8b1 solute carrier family 8 member B1 ISO RGD PMID:22850819 RGD:7204696 NCBI chrNW_004955482:9,594,872...9,617,136
Ensembl chrNW_004955482:9,595,604...9,605,271 		JBrowse link
G Stim1 stromal interaction molecule 1 ISO RGD PMID:22914293 RGD:7204692 NCBI chrNW_004955414:19,652,990...19,849,353
Ensembl chrNW_004955414:19,652,990...19,847,964 		JBrowse link
G Stim2 stromal interaction molecule 2 ISO RGD PMID:22914293 RGD:7204692 NCBI chrNW_004955443:18,281,245...18,424,750
Ensembl chrNW_004955443:18,278,464...18,366,522 		JBrowse link
G Tpcn1 two pore segment channel 1 ISO RGD PMID:20018950 RGD:7204697 NCBI chrNW_004955482:9,538,572...9,594,739
Ensembl chrNW_004955482:9,542,079...9,592,972 		JBrowse link
G Tpcn2 two pore segment channel 2 ISO RGD PMID:20018950 RGD:7204697 NCBI chrNW_004955422:16,899,730...16,923,962
Ensembl chrNW_004955422:16,900,239...16,923,978 		JBrowse link
G Trpv6 transient receptor potential cation channel subfamily V member 6 ISO RGD PMID:20716668 RGD:7204689 NCBI chrNW_004955494:820,801...835,931
Ensembl chrNW_004955494:818,643...836,126 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3924
    regulatory pathway 2432
      transport pathway 286
        ion transport pathway 66
          metal ion transport pathway 66
            calcium transport pathway 53
Path 2
Term Annotations click to browse term
  pathway 3924
    regulatory pathway 2432
      homeostasis pathway 1271
        inorganic chemical homeostasis pathway 289
          metal homeostasis pathway 197
            calcium homeostasis pathway 136
              calcium transport pathway 53
paths to the root