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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:calcium transport pathway
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Accession:PW:0001139 term browser browse the term
Definition:Calcium is pumped into organelles or out of the cell by pumps and exchangers to maintain the low calcium concentration necessary for cell viability. Many type of channels, some calcium-selective, others of lower selectivity or calcium-permeant, allow for the flow of calcium from external sources or internal stores into the cell to initiate many signaling events. The movement of calcium ions, which controls and maintains the calcium gradient, and calcium signaling, which the gradient promotes, are inextricably connected in the fabric of calcium homeostasis.
Synonyms:related_synonym: calcium ion transport
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calcium transport pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 ISO RGD PMID:19789383 RGD:7204695 Ensembl chr16:29,265,516...29,290,807
Ensembl chr16:29,265,516...29,290,807 		JBrowse link
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO RGD PMID:19789383 RGD:7204695 NCBI chr12:107,857,009...107,924,938
Ensembl chr12:111,246,508...111,311,923 		JBrowse link
G ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 ISO RGD PMID:19789383 RGD:7204695 NCBI chr17:3,992,088...4,013,998
Ensembl chr17:3,965,925...3,998,382 		JBrowse link
G ATP2B1 ATPase plasma membrane Ca2+ transporting 1 ISO RGD PMID:19789383 RGD:7204695 NCBI chr12:87,107,900...87,229,514
Ensembl chr12:90,427,560...90,495,320 		JBrowse link
G ATP2B2 ATPase plasma membrane Ca2+ transporting 2 ISO RGD PMID:19789383 RGD:7204695 NCBI chr 3:10,260,556...10,643,346
Ensembl chr 3:10,611,619...10,738,006 		JBrowse link
G ATP2B3 ATPase plasma membrane Ca2+ transporting 3 ISO RGD PMID:19789383 RGD:7204695 NCBI chr  X:143,068,171...143,133,479
Ensembl chr  X:152,955,109...153,019,445 		JBrowse link
G ATP2B4 ATPase plasma membrane Ca2+ transporting 4 ISO RGD PMID:19789383 RGD:7204695 NCBI chr 1:179,231,712...179,348,759
Ensembl chr 1:183,580,773...183,639,882 		JBrowse link
G ATP2C1 ATPase secretory pathway Ca2+ transporting 1 ISO RGD PMID:19789383 RGD:7204695 NCBI chr 3:127,937,272...128,101,060
Ensembl chr 3:135,260,796...135,423,700 		JBrowse link
G ATP2C2 ATPase secretory pathway Ca2+ transporting 2 ISO RGD PMID:19789383 RGD:7204695 NCBI chr16:65,033,470...65,127,403
Ensembl chr16:84,375,658...84,468,671 		JBrowse link
G CACNA1A calcium voltage-gated channel subunit alpha1 A ISO RGD PMID:21746798 RGD:7204688 NCBI chr19:12,769,586...13,189,022
Ensembl chr19:13,507,102...13,804,729 		JBrowse link
G CACNA1B calcium voltage-gated channel subunit alpha1 B ISO RGD PMID:21746798 RGD:7204688 NCBI chr 9:108,989,621...109,256,841 JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C ISO RGD PMID:21746798 RGD:7204688 NCBI chr12:2,166,672...2,817,827
Ensembl chr12:2,114,140...2,744,826 		JBrowse link
G CACNA1D calcium voltage-gated channel subunit alpha1 D ISO RGD PMID:21746798 RGD:7204688 NCBI chr 3:53,432,189...53,751,347
Ensembl chr 3:54,495,952...54,970,444 		JBrowse link
G CACNA1E calcium voltage-gated channel subunit alpha1 E ISO RGD PMID:21746798 RGD:7204688 NCBI chr 1:156,796,855...157,296,987
Ensembl chr 1:160,628,089...160,949,270 		JBrowse link
G CACNA1F calcium voltage-gated channel subunit alpha1 F ISO RGD PMID:21746798 RGD:7204688 NCBI chr  X:41,504,804...41,533,501
Ensembl chr  X:49,356,994...49,385,678 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G ISO RGD PMID:21746798 RGD:7204688 NCBI chr17:44,654,558...44,786,037
Ensembl chr17:49,529,402...49,595,166 		JBrowse link
G CACNA1H calcium voltage-gated channel subunit alpha1 H ISO RGD PMID:21746798 RGD:7204688 Ensembl chr16:1,195,364...1,222,917 JBrowse link
G CACNA1I calcium voltage-gated channel subunit alpha1 I ISO RGD PMID:21746798 RGD:7204688 NCBI chr22:20,463,511...20,595,253
Ensembl chr22:38,296,436...38,414,963 		JBrowse link
G CACNA1S calcium voltage-gated channel subunit alpha1 S ISO RGD PMID:21746798 RGD:7204688 NCBI chr 1:176,639,189...176,712,171
Ensembl chr 1:180,941,836...181,014,823 		JBrowse link
G CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 ISO RGD PMID:21746798 RGD:7204688 NCBI chr17:18,073,818...18,098,400
Ensembl chr17:18,349,146...18,373,338 		JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 ISO RGD PMID:21746798 RGD:7204688 NCBI chr10:18,459,528...18,862,495
Ensembl chr10:18,795,832...19,195,226 		JBrowse link
G CACNB3 calcium voltage-gated channel auxiliary subunit beta 3 ISO RGD PMID:21746798 RGD:7204688 NCBI chr12:39,918,022...39,931,386
Ensembl chr12:40,797,293...40,811,409 		JBrowse link
G CACNB4 calcium voltage-gated channel auxiliary subunit beta 4 ISO RGD PMID:21746798 RGD:7204688 NCBI chr2B:39,137,777...39,399,007
Ensembl chr2B:156,379,469...156,639,328 		JBrowse link
G CNGA1 cyclic nucleotide gated channel subunit alpha 1 ISO RGD PMID:12087135 RGD:6893549 NCBI chr 4:74,196,877...74,213,563
Ensembl chr 4:84,910,653...84,945,248 		JBrowse link
G CNGA2 cyclic nucleotide gated channel subunit alpha 2 ISO RGD PMID:12087135 RGD:6893549 NCBI chr  X:141,315,052...141,324,754
Ensembl chr  X:151,275,800...151,281,909 		JBrowse link
G CNGA3 cyclic nucleotide gated channel subunit alpha 3 ISO RGD PMID:12087135 RGD:6893549 NCBI chr2A:100,911,053...100,962,278
Ensembl chr2A:99,259,808...99,308,517 		JBrowse link
G CNGA4 cyclic nucleotide gated channel subunit alpha 4 ISO RGD PMID:12087135 RGD:6893549 NCBI chr11:6,368,768...6,378,976
Ensembl chr11:6,051,091...6,061,550 		JBrowse link
G CNGB1 cyclic nucleotide gated channel subunit beta 1 ISO RGD PMID:12087135 RGD:6893549 NCBI chr16:38,160,056...38,249,474
Ensembl chr16:57,292,093...57,375,460 		JBrowse link
G CNGB3 cyclic nucleotide gated channel subunit beta 3 ISO RGD PMID:12087135 RGD:6893549 NCBI chr 8:83,269,589...83,439,999
Ensembl chr 8:85,238,043...85,407,059 		JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 ISO RGD PMID:19133301 RGD:7204693 NCBI chr 3:4,448,574...4,802,545
Ensembl chr 3:4,572,921...4,904,811 		JBrowse link
G ITPR2 inositol 1,4,5-trisphosphate receptor type 2 ISO RGD PMID:19133301 RGD:7204693 NCBI chr12:59,478,206...59,984,572
Ensembl chr12:62,092,241...62,596,018 		JBrowse link
G ITPR3 inositol 1,4,5-trisphosphate receptor type 3 ISO RGD PMID:19133301 RGD:7204693 NCBI chr 6:33,194,531...33,269,788
Ensembl chr 6:34,303,454...34,378,215 		JBrowse link
G LOC100987781 calcium release-activated calcium channel protein 1 ISO RGD PMID:22914293 RGD:7204692 NCBI chr12:119,229,069...119,243,435 JBrowse link
G LOC100990398 transient receptor potential cation channel subfamily V member 6 ISO RGD PMID:20716668 RGD:7204689 NCBI chr 7:134,862,223...134,877,051
Ensembl chr 7:147,353,684...147,368,475 		JBrowse link
G MCOLN1 mucolipin TRP cation channel 1 ISO RGD PMID:20716668 RGD:7204689 NCBI chr19:6,813,498...6,825,153
Ensembl chr19:7,671,704...7,683,093 		JBrowse link
G MCU mitochondrial calcium uniporter ISO RGD PMID:22850819 RGD:7204696 NCBI chr10:69,243,282...69,435,193
Ensembl chr10:71,845,335...71,898,545 		JBrowse link
G ORAI2 ORAI calcium release-activated calcium modulator 2 ISO RGD PMID:22914293 RGD:7204692 NCBI chr 7:94,573,923...94,592,028 JBrowse link
G ORAI3 ORAI calcium release-activated calcium modulator 3 ISO RGD PMID:22914293 RGD:7204692 NCBI chr16:24,014,018...24,019,889
Ensembl chr16:31,314,922...31,323,320 		JBrowse link
G RYR1 ryanodine receptor 1 ISO RGD PMID:20961976 RGD:7204694 NCBI chr19:35,527,466...35,685,446
Ensembl chr19:44,106,036...44,256,327 		JBrowse link
G RYR2 ryanodine receptor 2 ISO RGD PMID:20961976 RGD:7204694 NCBI chr 1:212,600,198...213,387,312
Ensembl chr 1:217,815,676...218,383,509 		JBrowse link
G RYR3 ryanodine receptor 3 ISO RGD PMID:20961976 RGD:7204694 NCBI chr15:11,816,430...12,379,101
Ensembl chr15:30,817,428...31,214,494 		JBrowse link
G SLC24A1 solute carrier family 24 member 1 ISO RGD PMID:17716241 RGD:7204698 NCBI chr15:44,552,886...44,597,640
Ensembl chr15:62,831,987...62,882,431 		JBrowse link
G SLC24A2 solute carrier family 24 member 2 ISO RGD PMID:17716241 RGD:7204698 NCBI chr 9:19,317,132...19,593,503
Ensembl chr 9:19,814,244...20,249,225 		JBrowse link
G SLC24A3 solute carrier family 24 member 3 ISO RGD PMID:17716241 RGD:7204698 NCBI chr20:19,168,820...19,680,706
Ensembl chr20:19,137,938...19,646,475 		JBrowse link
G SLC24A4 solute carrier family 24 member 4 ISO RGD PMID:17716241 RGD:7204698 NCBI chr14:72,956,230...73,128,851
Ensembl chr14:92,299,507...92,468,939 		JBrowse link
G SLC24A5 solute carrier family 24 member 5 ISO RGD PMID:17716241 RGD:7204698 NCBI chr15:27,069,937...27,091,619
Ensembl chr15:45,394,090...45,415,823 		JBrowse link
G SLC8A1 solute carrier family 8 member A1 ISO RGD PMID:17716241 RGD:7204698 NCBI chr2A:40,169,339...40,586,546
Ensembl chr2A:40,939,900...41,363,038 		JBrowse link
G SLC8A2 solute carrier family 8 member A2 ISO RGD PMID:17716241 RGD:7204698 NCBI chr19:44,420,146...44,464,242
Ensembl chr19:53,077,857...53,113,830 		JBrowse link
G SLC8A3 solute carrier family 8 member A3 ISO RGD PMID:17716241 RGD:7204698 NCBI chr14:50,634,091...50,779,712 JBrowse link
G SLC8B1 solute carrier family 8 member B1 ISO RGD PMID:22850819 RGD:7204696 NCBI chr12:110,903,215...110,936,908
Ensembl chr12:114,286,624...114,319,683 		JBrowse link
G STIM1 stromal interaction molecule 1 ISO RGD PMID:22914293 RGD:7204692 NCBI chr11:3,726,501...3,954,951
Ensembl chr11:3,840,513...4,065,224 		JBrowse link
G STIM2 stromal interaction molecule 2 ISO RGD PMID:22914293 RGD:7204692 NCBI chr 4:21,262,272...21,424,944
Ensembl chr 4:26,537,703...26,694,416 		JBrowse link
G TPCN1 two pore segment channel 1 ISO RGD PMID:20018950 RGD:7204697 NCBI chr12:110,812,587...110,903,033
Ensembl chr12:114,209,638...114,286,443 		JBrowse link
G TPCN2 two pore segment channel 2 ISO RGD PMID:20018950 RGD:7204697 NCBI chr11:64,139,512...64,227,913
Ensembl chr11:67,438,635...67,478,106 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4064
    regulatory pathway 2507
      transport pathway 295
        ion transport pathway 68
          metal ion transport pathway 68
            calcium transport pathway 54
Path 2
Term Annotations click to browse term
  pathway 4064
    regulatory pathway 2507
      homeostasis pathway 1306
        inorganic chemical homeostasis pathway 292
          metal homeostasis pathway 200
            calcium homeostasis pathway 138
              calcium transport pathway 54
paths to the root