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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:altered citric acid cycle pathway
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Accession:PW:0001119 term browser browse the term
Definition:Defects in components of the citrate cycle have been shown to relate to several types of cancer. For instance, mutations in fumarate hydratase are associated with renal cancer, in succinate dehydrogenase in renal as well as paragangliomas and pheochromocytomas. Mutations in isocitrate dehydrogenase have also been implicated in several types of cancer. Defects in this central metabolic network result in unwanted activation of hypoxia inducible factor whose target genes are involved in angiogenesis, erythropoiesis, glycolysis, among others.



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altered citric acid cycle pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FH fumarate hydratase ISO RGD PMID:17211469 RGD:6907135 NCBI chr10:12,404,143...12,431,843
Ensembl chr10:12,404,176...12,431,824
JBrowse link
G SDHB succinate dehydrogenase complex iron sulfur subunit B ISO RGD PMID:21771581 RGD:6907134 NCBI chr 6:75,648,362...75,678,111
Ensembl chr 6:75,648,215...75,678,378
JBrowse link
G SDHD succinate dehydrogenase complex subunit D ISO RGD PMID:21771581 RGD:6907134 NCBI chr 9:39,790,654...39,803,602
Ensembl chr 9:39,790,595...39,803,950
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4047
    classic metabolic pathway 1013
      energy metabolic pathway 43
        altered energy metabolic pathway 3
          altered citric acid cycle pathway 3
Path 2
Term Annotations click to browse term
  pathway 4047
    regulatory pathway 2501
      altered regulatory pathway 76
        altered homeostasis pathway 29
          altered energy homeostasis pathway 12
            altered citric acid cycle pathway 3
paths to the root