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ONTOLOGY REPORT - ANNOTATIONS


Term:ribosome biogenesis pathway
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Accession:PW:0001066 term browser browse the term
Definition:The pathway of ribosome biogenesis starts with the transcription of rRNA precursors, involves the co-transciptional events of pre-rRNA processing and the assembly of pre-ribosomal particles. The maturation of pre-40S and pre-60S particles follows independent routes. Once in the cytoplasm, additional steps yield the mature, translation competent, ribosome. Alterations in the pathway result in specific phenotypes collectively known as ribosomopathies.
Synonyms:related_synonym: KEGG:03008

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ribosome biogenesis pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BMS1 BMS1 ribosome biogenesis factor JBrowse link 14 61,056,075 61,125,984 RGD:9068941
G BOP1 BOP1 ribosomal biogenesis factor JBrowse link 4 486,562 507,141 RGD:9068941
G BYSL bystin like JBrowse link 7 37,074,517 37,086,753 RGD:9068941
G C1D C1D nuclear receptor corepressor JBrowse link 3 74,133,665 74,153,756 RGD:9068941
G CSNK1D casein kinase 1 delta JBrowse link 12 768,856 794,495 RGD:9068941
G CSNK2A1 casein kinase 2 alpha 1 JBrowse link 17 34,692,960 34,748,067 RGD:9068941
G CSNK2A2 casein kinase 2 alpha 2 JBrowse link 6 19,975,030 20,016,768 RGD:9068941
G CSNK2B casein kinase 2 beta JBrowse link 7 23,781,194 23,787,914 RGD:9068941
G DDX10 DEAD-box helicase 10 JBrowse link 9 37,006,571 37,265,973 RGD:9068941
G DDX18 DEAD-box helicase 18 JBrowse link 15 23,425,674 23,442,985 RGD:9068941
G DDX24 DEAD-box helicase 24 JBrowse link 7 115,328,122 115,347,355 RGD:9068941
G DDX56 DEAD-box helicase 56 JBrowse link 18 50,705,613 50,714,967 RGD:9068941
G DHX15 DEAH-box helicase 15 JBrowse link 8 18,563,808 18,620,892 RGD:9068941
G DHX37 DEAH-box helicase 37 JBrowse link 14 28,206,152 28,242,436 RGD:9068941
G DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease JBrowse link 11 45,046,040 45,075,973 RGD:9068941
G DKC1 dyskerin pseudouridine synthase 1 JBrowse link X 125,218,928 125,228,881 RGD:9068941
G DROSHA drosha ribonuclease III JBrowse link 16 17,727,695 17,847,954 RGD:9068941
G EFL1 elongation factor like GTPase 1 JBrowse link 7 50,839,725 50,977,024 RGD:9068941
G EIF6 eukaryotic translation initiation factor 6 JBrowse link 17 38,638,295 38,643,918 RGD:9068941
G EMG1 EMG1 N1-specific pseudouridine methyltransferase JBrowse link 5 63,746,326 63,751,469 RGD:9068941
G ERI1 exoribonuclease 1 JBrowse link 15 56,091,790 56,123,520 RGD:9068941
G EXOSC10 exosome component 10 JBrowse link 6 71,258,988 71,282,802 RGD:9068941
G EXOSC5 exosome component 5 JBrowse link 6 49,373,378 49,381,875 RGD:9068941
G FAU FAU ubiquitin like and ribosomal protein S30 fusion JBrowse link 2 7,070,903 7,072,811 RGD:9068941
G FBL fibrillarin JBrowse link 6 48,314,782 48,326,433 RGD:9068941
G FCF1 FCF1 rRNA-processing protein JBrowse link 7 97,940,919 97,961,268 RGD:9068941
G GAR1 GAR1 ribonucleoprotein JBrowse link 8 112,401,114 112,414,277 RGD:9068941
G GNL2 G protein nucleolar 2 JBrowse link 6 93,621,443 93,645,980 RGD:9068941
G GNL3 G protein nucleolar 3 JBrowse link 13 34,820,243 34,828,523 RGD:9068941
G GNL3L G protein nucleolar 3 like JBrowse link X 47,256,467 47,284,520 RGD:9068941
G GTPBP4 GTP binding protein 4 JBrowse link 10 68,547,316 68,566,040 RGD:9068941
G HEATR1 HEAT repeat containing 1 JBrowse link 14 54,821,073 54,870,873 RGD:9068941
G IMP3 IMP U3 small nucleolar ribonucleoprotein 3 JBrowse link 7 58,023,368 58,024,496 RGD:9068941
G IMP4 IMP U3 small nucleolar ribonucleoprotein 4 JBrowse link 15 31,970,179 31,975,158 RGD:9068941
G LOC100153087 nuclear RNA export factor 2 JBrowse link X 83,338,757 83,361,973 RGD:9068941
G LOC100523244 casein kinase I JBrowse link 5 9,594,461 9,620,483 RGD:9068941
G LOC100739087 60S ribosomal protein L14-like JBrowse link 1 56,689,050 56,689,768 RGD:9068941
G LOC102164431 nuclear RNA export factor 3-like JBrowse link X 83,980,605 83,989,335 RGD:9068941
G LSG1 large 60S subunit nuclear export GTPase 1 JBrowse link 13 131,623,530 131,653,930 RGD:9068941
G LTV1 LTV1 ribosome biogenesis factor JBrowse link 1 21,406,949 21,430,252 RGD:9068941
G MDN1 midasin AAA ATPase 1 JBrowse link 1 57,660,222 57,826,362 RGD:9068941
G MPHOSPH10 M-phase phosphoprotein 10 JBrowse link 1 143,972,587 143,994,036 RGD:9068941
G MPP6 membrane palmitoylated protein 6 JBrowse link 18 47,589,547 47,711,433 RGD:9068941
G MTREX Mtr4 exosome RNA helicase JBrowse link 16 34,478,227 34,605,508 RGD:9068941
G NAT10 N-acetyltransferase 10 JBrowse link 2 26,786,172 26,827,060 RGD:9068941
G NHP2 NHP2 ribonucleoprotein JBrowse link 2 80,223,439 80,227,614 RGD:9068941
G NMD3 NMD3 ribosome export adaptor JBrowse link 13 100,924,685 100,992,009 RGD:9068941
G NOB1 NIN1 (RPN12) binding protein 1 homolog JBrowse link 6 17,233,863 17,245,451 RGD:9068941
G NOL12 nucleolar protein 12 JBrowse link 5 10,137,362 10,144,156 RGD:9068941
G NOL6 nucleolar protein 6 JBrowse link 10 33,022,035 33,035,201 RGD:9068941
G NOP10 NOP10 ribonucleoprotein JBrowse link 7 80,161,024 80,162,299 RGD:9068941
G NOP56 NOP56 ribonucleoprotein JBrowse link 17 32,960,099 32,965,396 RGD:9068941
G NOP58 NOP58 ribonucleoprotein JBrowse link 15 105,893,589 105,930,458 RGD:9068941
G NUP214 nucleoporin 214 JBrowse link 1 271,103,838 271,210,292 RGD:9068941
G NUP88 nucleoporin 88 JBrowse link 12 51,562,455 51,603,095 RGD:9068941
G NVL nuclear VCP like JBrowse link 10 12,564,891 12,670,641 RGD:9068941
G NXF1 nuclear RNA export factor 1 JBrowse link 2 8,968,659 8,983,276 RGD:9068941
G NXT1 nuclear transport factor 2 like export factor 1 JBrowse link 17 30,338,379 30,341,629 RGD:9068941
G NXT2 nuclear transport factor 2 like export factor 2 JBrowse link X 89,684,733 89,691,808 RGD:9068941
G PDCD11 programmed cell death 11 JBrowse link 14 114,327,583 114,382,002 RGD:9068941
G PES1 pescadillo ribosomal biogenesis factor 1 JBrowse link 14 47,478,378 47,495,983 RGD:9068941
G PNO1 partner of NOB1 homolog JBrowse link 3 74,071,621 74,084,896 RGD:9068941
G POP1 POP1 homolog, ribonuclease P/MRP subunit JBrowse link 4 38,608,536 38,656,204 RGD:9068941
G POP4 POP4 homolog, ribonuclease P/MRP subunit JBrowse link 6 39,734,523 39,745,972 RGD:9068941
G POP5 POP5 homolog, ribonuclease P/MRP subunit JBrowse link 14 40,523,014 40,525,934 RGD:9068941
G POP7 POP7 homolog, ribonuclease P/MRP subunit JBrowse link 3 8,607,531 8,609,391 RGD:9068941
G PRKCB protein kinase C beta JBrowse link 3 21,995,227 22,383,628 RGD:9068941
G PWP2 PWP2 small subunit processome component JBrowse link 13 207,015,047 207,031,752 RGD:9068941
G RACK1 receptor for activated C kinase 1 JBrowse link 2 57,280,192 57,284,846 RGD:9068941
G RAN RAN, member RAS oncogene family JBrowse link 14 24,312,810 24,318,024 RGD:9068941
G RBM28 RNA binding motif protein 28 JBrowse link 18 20,034,305 20,069,159 RGD:9068941
G RCL1 RNA terminal phosphate cyclase like 1 JBrowse link 1 217,142,965 217,204,960 RGD:9068941
G REXO1 RNA exonuclease 1 homolog JBrowse link 2 76,694,269 76,719,026 RGD:9068941
G REXO2 RNA exonuclease 2 JBrowse link 9 41,977,969 41,988,699 RGD:9068941
G RIOK1 RIO kinase 1 JBrowse link 7 4,750,766 4,776,678 RGD:9068941
G RIOK2 RIO kinase 2 JBrowse link 2 103,802,044 103,823,566 RGD:9068941
G RIOK3 RIO kinase 3 JBrowse link 6 108,338,986 108,363,872 RGD:9068941
G RPL10 ribosomal protein L10 JBrowse link X 124,927,249 124,929,791 RGD:9068941
G RPL10A ribosomal protein L10a JBrowse link 7 31,327,763 31,330,624 RGD:9068941
G RPL11 ribosomal protein L11 JBrowse link 6 81,523,510 81,526,925 RGD:9068941
G RPL12 ribosomal protein L12 JBrowse link 1 267,961,398 267,964,881 RGD:9068941
G RPL13 ribosomal protein L13 JBrowse link 6 410,923 413,396 RGD:9068941
G RPL13A ribosomal protein L13a JBrowse link 6 54,551,772 54,568,752 RGD:9068941
G RPL15 ribosomal protein L15 JBrowse link 13 10,716,373 10,719,959 RGD:9068941
G RPL17 ribosomal protein L17 JBrowse link 1 99,044,511 99,048,406 RGD:9068941
G RPL18 ribosomal protein L18 JBrowse link 6 53,974,353 53,978,681 RGD:9068941
G RPL18A ribosomal protein L18a JBrowse link 2 59,892,788 59,906,242 RGD:9068941
G RPL19 ribosomal protein L19 JBrowse link 12 23,029,377 23,034,337 RGD:9068941
G RPL21 ribosomal protein L21 JBrowse link 11 4,731,747 4,736,177 RGD:9068941
G RPL22 ribosomal protein L22 JBrowse link 6 67,092,892 67,102,086 RGD:9068941
G RPL23 ribosomal protein L23 JBrowse link 12 23,279,965 23,285,538 RGD:9068941
G RPL23A ribosomal protein L23a JBrowse link 12 44,956,851 44,960,737 RGD:9068941
G RPL24 ribosomal protein L24 JBrowse link 13 157,411,933 157,418,663 RGD:9068941
G RPL26 ribosomal protein L26 JBrowse link 12 53,548,313 53,553,453 RGD:9068941
G RPL27 ribosomal protein L27 JBrowse link 12 19,892,210 19,894,202 RGD:9068941
G RPL27A ribosomal protein L27a JBrowse link 9 708,531 712,410 RGD:9068941
G RPL28 ribosomal protein L28 JBrowse link 6 59,556,586 59,559,337 RGD:9068941
G RPL29 ribosomal protein L29 JBrowse link 13 34,119,541 34,121,842 RGD:9068941
G RPL3 ribosomal protein L3 JBrowse link 5 8,922,697 8,929,768 RGD:9068941
G RPL30 ribosomal protein L30 JBrowse link 4 38,702,220 38,720,420 RGD:9068941
G RPL31 ribosomal protein L31 JBrowse link 3 53,289,993 53,295,387 RGD:9068941
G RPL32 ribosomal protein L32 JBrowse link 13 68,788,109 68,793,265 RGD:9068941
G RPL34 ribosomal protein L34 JBrowse link 8 113,467,779 113,472,058 RGD:9068941
G RPL35 ribosomal protein L35 JBrowse link 1 265,637,266 265,642,278 RGD:9068941
G RPL35A ribosomal protein L35a JBrowse link 13 134,588,288 134,591,873 RGD:9068941
G RPL36 ribosomal protein L36 JBrowse link 2 73,286,906 73,288,512 RGD:9068941
G RPL37 ribosomal protein L37 JBrowse link 16 25,800,883 25,803,526 RGD:9068941
G RPL37A ribosomal protein L37a JBrowse link 15 118,702,198 118,704,974 RGD:9068941
G RPL38 ribosomal protein L38 JBrowse link 12 6,884,899 6,889,966 RGD:9068941
G RPL39 ribosomal protein L39 JBrowse link X 98,178,148 98,181,439 RGD:9068941
G RPL4 ribosomal protein L4 JBrowse link 1 164,476,269 164,481,765 RGD:9068941
G RPL5 ribosomal protein L5 JBrowse link 4 124,359,786 124,367,612 RGD:9068941
G RPL6 ribosomal protein L6 JBrowse link 14 39,302,447 39,309,239 RGD:9068941
G RPL7 ribosomal protein L7 JBrowse link 4 62,602,430 62,605,892 RGD:9068941
G RPL7A ribosomal protein L7a JBrowse link 1 272,961,421 272,965,636 RGD:9068941
G RPL8 ribosomal protein L8 JBrowse link 4 136,105 138,651 RGD:9068941
G RPL9 ribosomal protein L9 JBrowse link 8 30,693,198 30,699,189 RGD:9068941
G RPLP0 ribosomal protein lateral stalk subunit P0 JBrowse link 14 40,219,196 40,223,943 RGD:9068941
G RPLP1 ribosomal protein lateral stalk subunit P1 JBrowse link 1 167,296,084 167,298,264 RGD:9068941
G RPLP2 ribosomal protein lateral stalk subunit P2 JBrowse link 2 507,891 509,818 RGD:9068941
G RPP25 ribonuclease P and MRP subunit p25 JBrowse link 7 58,605,850 58,610,086 RGD:9068941
G RPP30 ribonuclease P/MRP subunit p30 JBrowse link 14 102,565,802 102,606,046 RGD:9068941
G RPP38 ribonuclease P/MRP subunit p38 JBrowse link 10 46,720,135 46,725,962 RGD:9068941
G RPP40 ribonuclease P/MRP subunit p40 JBrowse link 7 2,990,405 3,042,423 RGD:9068941
G RPS10 ribosomal protein S10 JBrowse link 7 30,435,146 30,442,791 RGD:9068941
G RPS11 ribosomal protein S11 JBrowse link 6 54,577,414 54,579,797 RGD:9068941
G RPS12 ribosomal protein S12 JBrowse link 1 30,920,804 30,923,392 RGD:9068941
G RPS13 ribosomal protein S13 JBrowse link 2 42,030,585 42,033,382 RGD:9068941
G RPS14 ribosomal protein S14 JBrowse link 2 151,430,047 151,433,951 RGD:9068941
G RPS15 ribosomal protein S15 JBrowse link 2 77,043,329 77,044,749 RGD:9068941
G RPS15A ribosomal protein S15a JBrowse link 3 26,776,661 26,783,491 RGD:9068941
G RPS16 ribosomal protein S16 JBrowse link 6 48,085,684 48,088,368 RGD:9068941
G RPS17 ribosomal protein S17 JBrowse link 7 52,386,342 52,389,003 RGD:9068941
G RPS18 ribosomal protein S18 JBrowse link 7 29,638,856 29,642,912 RGD:9068941
G RPS19 ribosomal protein S19 JBrowse link 6 50,003,198 50,010,135 RGD:9068941
G RPS2 ribosomal protein S2 JBrowse link 3 39,996,179 40,003,110 RGD:9068941
G RPS20 ribosomal protein S20 JBrowse link 4 75,762,209 75,763,449 RGD:9068941
G RPS21 ribosomal protein S21 JBrowse link 17 61,763,606 61,764,823 RGD:9068941
G RPS23 ribosomal protein S23 JBrowse link 2 90,679,038 90,680,681 RGD:9068941
G RPS24 ribosomal protein S24 JBrowse link 14 80,473,867 80,480,818 RGD:9068941
G RPS25 ribosomal protein S25 JBrowse link 9 46,237,911 46,242,174 RGD:9068941
G RPS26 ribosomal protein S26 JBrowse link 5 21,431,656 21,433,691 RGD:9068941
G RPS27 ribosomal protein S27 JBrowse link 4 95,697,869 95,699,481 RGD:9068941
G RPS27A ribosomal protein S27a JBrowse link 3 85,989,609 85,992,257 RGD:9068941
G RPS27L ribosomal protein S27 like JBrowse link 1 108,881,330 108,886,334 RGD:9068941
G RPS28 ribosomal protein S28 JBrowse link 2 70,953,706 70,954,862 RGD:9068941
G RPS29 ribosomal protein S29 JBrowse link 1 179,454,923 179,456,847 RGD:9068941
G RPS3 ribosomal protein S3 JBrowse link 9 9,612,939 9,630,404 RGD:9068941
G RPS3A ribosomal protein S3A JBrowse link 8 77,889,616 77,893,740 RGD:9068941
G RPS4X ribosomal protein S4 X-linked JBrowse link X 58,149,302 58,155,179 RGD:9068941
G RPS5 ribosomal protein S5 JBrowse link 6 62,967,955 62,974,353 RGD:9068941
G RPS6 ribosomal protein S6 JBrowse link 1 203,444,360 203,447,643 RGD:9068941
G RPS7 ribosomal protein S7 JBrowse link 3 131,258,709 131,263,285 RGD:9068941
G RPS8 ribosomal protein S8 JBrowse link 6 166,550,574 166,553,289 RGD:9068941
G RPS9 ribosomal protein S9 JBrowse link 6 55,920,930 55,927,280 RGD:9068941
G RPSA ribosomal protein SA JBrowse link 13 24,072,551 24,081,536 RGD:9068941
G RRP12 ribosomal RNA processing 12 homolog JBrowse link 14 108,772,172 108,805,513 RGD:9068941
G RRP7A ribosomal RNA processing 7 homolog A JBrowse link 5 6,208,495 6,217,381 RGD:9068941
G SBDS SBDS ribosome maturation factor JBrowse link 3 16,161,524 16,168,619 RGD:9068941
G SNU13 small nuclear ribonucleoprotein 13 JBrowse link 5 6,891,014 6,900,026 RGD:9068941
G SPATA5 spermatogenesis associated 5 JBrowse link 8 100,918,331 101,241,099 RGD:9068941
G TAF9 TATA-box binding protein associated factor 9 JBrowse link 16 47,494,841 47,499,568 RGD:9068941
G TBL3 transducin beta like 3 JBrowse link 3 39,989,739 39,996,138 RGD:9068941
G TCOF1 treacle ribosome biogenesis factor 1 JBrowse link 2 151,368,264 151,401,029 RGD:9068941
G UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 JBrowse link 2 59,238,802 59,241,512 RGD:9068941
G UTP14A UTP14A small subunit processome component JBrowse link X 106,479,028 106,500,389 RGD:9068941
G UTP15 UTP15 small subunit processome component JBrowse link 2 82,715,411 82,733,042 RGD:9068941
G UTP18 UTP18 small subunit processome component JBrowse link 12 27,526,180 27,565,177 RGD:9068941
G UTP23 UTP23 small subunit processome component JBrowse link 4 21,934,796 21,940,994 RGD:9068941
G UTP4 UTP4 small subunit processome component JBrowse link 6 17,784,908 17,818,417 RGD:9068941
G UTP6 UTP6 small subunit processome component JBrowse link 12 43,061,579 43,089,479 RGD:9068941
G WDR3 WD repeat domain 3 JBrowse link 4 102,841,459 102,878,636 RGD:9068941
G WDR36 WD repeat domain 36 JBrowse link 2 115,835,099 115,907,643 RGD:9068941
G WDR43 WD repeat domain 43 JBrowse link 3 110,317,549 110,365,108 RGD:9068941
G WDR75 WD repeat domain 75 JBrowse link 15 93,981,054 94,026,479 RGD:9068941
G XPO1 exportin 1 JBrowse link 3 80,255,016 80,300,260 RGD:9068941
G XPO5 exportin 5 JBrowse link 7 38,530,704 38,569,558 RGD:9068941
G XRN1 5'-3' exoribonuclease 1 JBrowse link 13 83,063,810 83,174,497 RGD:9068941
G XRN2 5'-3' exoribonuclease 2 JBrowse link 17 29,107,641 29,193,500 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5631
    regulatory pathway 3437
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1605
        translation pathway 220
          ribosome biogenesis pathway 179
            altered ribosome biogenesis pathway 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.