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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:anti-infective drug pathway
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Accession:PW:0000996 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics of compounds used as anti-infective agents. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.



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adefovir pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AK1 adenylate kinase 1 ISO SMPDB SMP:00629 NCBI chr 9:55,539,179...55,548,132
Ensembl chr 9:55,539,260...55,548,132
JBrowse link
G AK2 adenylate kinase 2 ISO SMPDB SMP:00629 NCBI chr 2:68,342,769...68,371,769
Ensembl chr 2:68,350,057...68,371,090
JBrowse link
G NME1 non-metastatic cells 1, protein (NM23A) expressed in ISO SMPDB SMP:00629 NCBI chr 9:26,990,336...26,998,895
Ensembl chr 9:26,990,469...26,998,955
JBrowse link
G NME2 non-metastatic cells 2, protein (NM23B) expressed in ISO SMPDB SMP:00629 NCBI chr 9:27,002,114...27,005,740
Ensembl chr 9:27,001,733...27,015,934
JBrowse link
lamivudine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO SMPDB SMP:00649 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00649 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00649 NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740
JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00649 NCBI chr 9:26,551,953...26,596,330
Ensembl chr 9:26,551,268...26,595,646
JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 ISO SMPDB SMP:00649 NCBI chr22:45,767,033...46,013,577
Ensembl chr22:45,765,835...46,013,505
JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 ISO SMPDB SMP:00649 NCBI chr32:11,443,778...11,517,674
Ensembl chr32:11,443,780...11,517,674
JBrowse link
G CHPT1 choline phosphotransferase 1 ISO SMPDB SMP:00649 NCBI chr15:40,602,570...40,631,422 JBrowse link
G CMPK1 cytidine/uridine monophosphate kinase 1 ISO SMPDB SMP:00649 NCBI chr15:13,324,235...13,357,387
Ensembl chr15:13,326,185...13,358,152
JBrowse link
G DCK deoxycytidine kinase ISO SMPDB SMP:00649 NCBI chr13:60,206,742...60,236,338
Ensembl chr13:60,205,937...60,235,678
JBrowse link
G NME1 non-metastatic cells 1, protein (NM23A) expressed in ISO SMPDB SMP:00649 NCBI chr 9:26,990,336...26,998,895
Ensembl chr 9:26,990,469...26,998,955
JBrowse link
G NT5C 5', 3'-nucleotidase, cytosolic ISO SMPDB SMP:00649 NCBI chr 9:5,342,793...5,344,432
Ensembl chr 9:5,343,378...5,344,380
JBrowse link
G PCYT1A phosphate cytidylyltransferase 1A, choline ISO SMPDB SMP:00649 NCBI chr33:29,363,282...29,414,635
Ensembl chr33:29,358,452...29,430,424
JBrowse link
G PCYT2 phosphate cytidylyltransferase 2, ethanolamine ISO SMPDB SMP:00649 NCBI chr 9:383,714...390,164
Ensembl chr 9:376,445...442,919
JBrowse link
G PGK1 phosphoglycerate kinase 1 ISO SMPDB SMP:00649 NCBI chr  X:60,374,743...60,396,244
Ensembl chr  X:60,374,754...60,423,947
JBrowse link
G SLC22A1 solute carrier family 22 member 1 ISO SMPDB SMP:00649 NCBI chr 1:49,268,978...49,296,522 JBrowse link
G SLC22A2 solute carrier family 22 member 2 ISO SMPDB SMP:00649 NCBI chr 1:49,327,621...49,348,435
Ensembl chr 1:49,327,296...49,348,435
JBrowse link
G SLC22A3 solute carrier family 22 member 3 ISO SMPDB SMP:00649 NCBI chr 1:49,407,949...49,496,627
Ensembl chr 1:49,407,966...49,496,620
JBrowse link
G SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 ISO SMPDB SMP:00649 NCBI chr 6:18,176,156...18,179,492
Ensembl chr 6:18,176,355...18,179,489
JBrowse link
neviparine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC10 ATP binding cassette subfamily C member 10 ISO SMPDB SMP:00642 NCBI chr12:11,898,493...11,919,622
Ensembl chr12:11,898,352...11,919,609
JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 ISO SMPDB SMP:00642 NCBI chr 1:84,940,411...84,994,789
Ensembl chr 1:84,940,411...84,994,789
JBrowse link
G CYP2B6 cytochrome P450 2B11 ISO SMPDB SMP:00642 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293
JBrowse link
G CYP2C41 cytochrome P450 2C41 ISO SMPDB SMP:00642
G CYP2D15 cytochrome P450 family 2 subfamily D member 15 ISO SMPDB SMP:00642 NCBI chr10:23,255,259...23,259,380
Ensembl chr10:23,255,249...23,259,298
JBrowse link
G CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 ISO SMPDB SMP:00642 NCBI chr 6:9,836,685...9,869,520
Ensembl chr 6:9,777,659...9,869,352
JBrowse link
tenofovir pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AK1 adenylate kinase 1 ISO SMPDB SMP:00630 NCBI chr 9:55,539,179...55,548,132
Ensembl chr 9:55,539,260...55,548,132
JBrowse link
G AK2 adenylate kinase 2 ISO SMPDB SMP:00630 NCBI chr 2:68,342,769...68,371,769
Ensembl chr 2:68,350,057...68,371,090
JBrowse link
G NME1 non-metastatic cells 1, protein (NM23A) expressed in ISO SMPDB SMP:00630 NCBI chr 9:26,990,336...26,998,895
Ensembl chr 9:26,990,469...26,998,955
JBrowse link
G NME2 non-metastatic cells 2, protein (NM23B) expressed in ISO SMPDB SMP:00630 NCBI chr 9:27,002,114...27,005,740
Ensembl chr 9:27,001,733...27,015,934
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4046
    drug pathway 379
      anti-infective drug pathway 27
        abacavir drug pathway + 0
        adefovir drug pathway + 4
        amikacin drug pathway + 0
        arbekacin drug pathway + 0
        azithromycin drug pathway + 0
        didanosine drug pathway + 0
        erythromycin drug pathway + 0
        gentamicin drug pathway + 0
        kanamycin drug pathway + 0
        lamivudine drug pathway + 18
        neviparine drug pathway + 6
        stavudine drug pathway + 0
        streptomycin drug pathway + 0
        tenofovir drug pathway + 4
        tobramycin drug pathway + 0
        zidovudine drug pathway + 0
paths to the root