PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: respiratory system drug pathway
Accession: PW:0000924
browse the term
Definition: The pharmacokinetics and pharmacodynamics of compounds used for the treatment of conditions associated with the respiratory system. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.
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Abcc8
ATP binding cassette subfamily C member 8
ISO
SMPDB
SMP:00296
NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510
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Abcc9
ATP binding cassette subfamily C member 9
ISO
SMPDB
SMP:00296
NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356
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Adrb1
adrenoceptor beta 1
ISO
SMPDB RGD
PMID:19127141
SMP:00296, RGD:4140443
NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259
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Adrb2
adrenoceptor beta 2
ISO
RGD
PMID:19127141 PMID:18426615
RGD:4140443 , RGD:4140444
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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Agtr1a
angiotensin II receptor, type 1a
ISO
SMPDB
SMP:00296
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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Atp1a1
ATPase Na+/K+ transporting subunit alpha 1
ISO
SMPDB
SMP:00296
NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837
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Atp1a2
ATPase Na+/K+ transporting subunit alpha 2
ISO
SMPDB
SMP:00296
NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
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Atp1a3
ATPase Na+/K+ transporting subunit alpha 3
ISO
SMPDB
SMP:00296
NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918
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Atp1a4
ATPase Na+/K+ transporting subunit alpha 4
ISO
SMPDB
SMP:00296
NCBI chr13:84,683,766...84,719,790
Ensembl chr13:84,683,768...84,719,687
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Atp1b1
ATPase Na+/K+ transporting subunit beta 1
ISO
SMPDB
SMP:00296
NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
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Atp1b2
ATPase Na+/K+ transporting subunit beta 2
ISO
SMPDB
SMP:00296
NCBI chr10:54,318,698...54,324,933
Ensembl chr10:54,318,701...54,324,933
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Atp1b3
ATPase Na+/K+ transporting subunit beta 3
ISO
SMPDB
SMP:00296
NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598
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Atp1b4
ATPase Na+/K+ transporting family member beta 4
ISO
SMPDB
SMP:00296
NCBI chr X:117,087,284...117,108,023
Ensembl chr X:117,057,423...117,108,020
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Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
ISO
SMPDB
SMP:00296
NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
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Cacna1c
calcium voltage-gated channel subunit alpha1 C
ISO
SMPDB
SMP:00296
NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
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Cacna1g
calcium voltage-gated channel subunit alpha1 G
ISO
SMPDB
SMP:00296
NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752
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Cacna1h
calcium voltage-gated channel subunit alpha1 H
ISO
SMPDB
SMP:00296
NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
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Cacna2d2
calcium voltage-gated channel auxiliary subunit alpha2delta 2
ISO
SMPDB
SMP:00296
NCBI chr 8:108,072,208...108,203,516
Ensembl chr 8:108,072,454...108,203,173
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Cacnb1
calcium voltage-gated channel auxiliary subunit beta 1
ISO
SMPDB
SMP:00296
NCBI chr10:82,998,182...83,018,838
Ensembl chr10:82,998,182...83,018,694
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Calm1
calmodulin 1
ISO
SMPDB
SMP:00296
NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
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Chrm2
cholinergic receptor, muscarinic 2
ISO
SMPDB
SMP:00296
NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
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Dlg1
discs large MAGUK scaffold protein 1
ISO
SMPDB
SMP:00296
NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689
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Fxyd2
FXYD domain-containing ion transport regulator 2
ISO
SMPDB
SMP:00296
NCBI chr 8:45,712,901...45,720,032
Ensembl chr 8:45,712,903...45,720,203
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Hcn4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
ISO
SMPDB
SMP:00296
NCBI chr 8:59,222,206...59,259,626
Ensembl chr 8:59,221,653...59,259,639
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Itpr1
inositol 1,4,5-trisphosphate receptor, type 1
ISO
SMPDB
SMP:00296
NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
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Kcna5
potassium voltage-gated channel subfamily A member 5
ISO
SMPDB
SMP:00296
NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
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Kcnd3
potassium voltage-gated channel subfamily D member 3
ISO
SMPDB
SMP:00296
NCBI chr 2:192,937,950...193,155,345
Ensembl chr 2:192,937,950...193,155,345
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Kcne1
potassium voltage-gated channel subfamily E regulatory subunit 1
ISO
SMPDB
SMP:00296
NCBI chr11:31,580,951...31,594,116
Ensembl chr11:31,580,742...31,593,901
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Kcne2
potassium voltage-gated channel subfamily E regulatory subunit 2
ISO
SMPDB
SMP:00296
NCBI chr11:31,517,176...31,530,026
Ensembl chr11:31,295,614...31,530,043
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Kcnh2
potassium voltage-gated channel subfamily H member 2
ISO
SMPDB
SMP:00296
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Kcnip2
potassium voltage-gated channel interacting protein 2
ISO
SMPDB
SMP:00296
NCBI chr 1:244,641,147...244,664,939
Ensembl chr 1:244,641,150...244,664,874
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Kcnj11
potassium inwardly-rectifying channel, subfamily J, member 11
ISO
SMPDB
SMP:00296
NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082
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Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
ISO
SMPDB
SMP:00296
NCBI chr10:96,060,834...96,071,397
Ensembl chr10:96,060,821...96,071,445
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Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
ISO
SMPDB
SMP:00296
NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124
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Kcnj4
potassium inwardly-rectifying channel, subfamily J, member 4
ISO
SMPDB
SMP:00296
NCBI chr 7:111,047,097...111,074,151
Ensembl chr 7:111,047,094...111,074,151
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Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
ISO
SMPDB
SMP:00296
NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518
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Kcnj8
potassium inwardly-rectifying channel, subfamily J, member 8
ISO
SMPDB
SMP:00296
NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603
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Kcnk1
potassium two pore domain channel subfamily K member 1
ISO
SMPDB
SMP:00296
NCBI chr19:53,959,411...53,997,726
Ensembl chr19:53,959,657...53,997,724
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Kcnq1
potassium voltage-gated channel subfamily Q member 1
ISO
SMPDB
SMP:00296
NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669
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Mylk
myosin light chain kinase
ISO
SMPDB
SMP:00296
NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
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Plcb1
phospholipase C beta 1
ISO
SMPDB
SMP:00296
NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869
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Pln
phospholamban
ISO
SMPDB
SMP:00296
NCBI chr20:32,629,537...32,639,559
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Prkaca
protein kinase cAMP-activated catalytic subunit alpha
ISO
SMPDB
SMP:00296
NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
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Prkar1a
protein kinase cAMP-dependent type I regulatory subunit alpha
ISO
SMPDB
SMP:00296
NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041
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Ryr2
ryanodine receptor 2
ISO
SMPDB
SMP:00296
NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
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Scn5a
sodium voltage-gated channel alpha subunit 5
ISO
SMPDB
SMP:00296
NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
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Slc8a1
solute carrier family 8 member A1
ISO
SMPDB
SMP:00296
NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628
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Snta1
syntrophin, alpha 1
ISO
SMPDB
SMP:00296
NCBI chr 3:142,876,285...142,906,737
Ensembl chr 3:142,876,296...142,906,709
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Sntb1
syntrophin, beta 1
ISO
SMPDB
SMP:00296
NCBI chr 7:87,060,926...87,329,315
Ensembl chr 7:87,060,926...87,329,315
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Sntb2
syntrophin, beta 2
ISO
SMPDB
SMP:00296
NCBI chr19:34,831,657...34,922,325
Ensembl chr19:34,831,584...34,914,113
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Tnnc1
troponin C1, slow skeletal and cardiac type
ISO
SMPDB
SMP:00296
NCBI chr16:6,400,801...6,405,634
Ensembl chr16:6,402,171...6,405,634
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Tnnc2
troponin C2, fast skeletal type
ISO
SMPDB
SMP:00296
NCBI chr 3:153,513,272...153,516,033
Ensembl chr 3:153,513,271...153,516,029
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Tnni1
troponin I1, slow skeletal type
ISO
SMPDB
SMP:00296
NCBI chr13:47,229,217...47,241,640
Ensembl chr13:47,229,216...47,241,644
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Tnni2
troponin I2, fast skeletal type
ISO
SMPDB
SMP:00296
NCBI chr 1:197,595,012...197,597,554
Ensembl chr 1:197,594,813...197,597,560
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Tnni3
troponin I3, cardiac type
ISO
SMPDB
SMP:00296
NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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Tnnt1
troponin T1, slow skeletal type
ISO
SMPDB
SMP:00296
NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721
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Tnnt2
troponin T2, cardiac type
ISO
SMPDB
SMP:00296
NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
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Tnnt3
troponin T3, fast skeletal type
ISO
SMPDB
SMP:00296
NCBI chr 1:197,652,535...197,669,736
Ensembl chr 1:197,652,431...197,669,535
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Tpm1
tropomyosin 1
ISO
SMPDB
SMP:00296
NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802
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Tpm2
tropomyosin 2
ISO
SMPDB
SMP:00296
NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992
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Adra1a
adrenoceptor alpha 1A
ISO
SMPDB
SMP:00681
NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
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Atp1a1
ATPase Na+/K+ transporting subunit alpha 1
ISO
SMPDB
SMP:00681
NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837
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Atp1a2
ATPase Na+/K+ transporting subunit alpha 2
ISO
SMPDB
SMP:00681
NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
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Atp1a3
ATPase Na+/K+ transporting subunit alpha 3
ISO
SMPDB
SMP:00681
NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918
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Atp1a4
ATPase Na+/K+ transporting subunit alpha 4
ISO
SMPDB
SMP:00681
NCBI chr13:84,683,766...84,719,790
Ensembl chr13:84,683,768...84,719,687
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Atp1b1
ATPase Na+/K+ transporting subunit beta 1
ISO
SMPDB
SMP:00681
NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
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Atp1b2
ATPase Na+/K+ transporting subunit beta 2
ISO
SMPDB
SMP:00681
NCBI chr10:54,318,698...54,324,933
Ensembl chr10:54,318,701...54,324,933
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Atp1b3
ATPase Na+/K+ transporting subunit beta 3
ISO
SMPDB
SMP:00681
NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598
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Atp1b4
ATPase Na+/K+ transporting family member beta 4
ISO
SMPDB
SMP:00681
NCBI chr X:117,087,284...117,108,023
Ensembl chr X:117,057,423...117,108,020
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Cacna1a
calcium voltage-gated channel subunit alpha1 A
ISO
SMPDB
SMP:00681
NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
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Cacna2d2
calcium voltage-gated channel auxiliary subunit alpha2delta 2
ISO
SMPDB
SMP:00681
NCBI chr 8:108,072,208...108,203,516
Ensembl chr 8:108,072,454...108,203,173
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Cacnb1
calcium voltage-gated channel auxiliary subunit beta 1
ISO
SMPDB
SMP:00681
NCBI chr10:82,998,182...83,018,838
Ensembl chr10:82,998,182...83,018,694
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Chrna4
cholinergic receptor nicotinic alpha 4 subunit
ISO
SMPDB
SMP:00681
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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Chrnb2
cholinergic receptor nicotinic beta 2 subunit
ISO
SMPDB
SMP:00681
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
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Drd1
dopamine receptor D1
ISO
SMPDB
SMP:00681
NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
G
Fxyd2
FXYD domain-containing ion transport regulator 2
ISO
SMPDB
SMP:00681
NCBI chr 8:45,712,901...45,720,032
Ensembl chr 8:45,712,903...45,720,203
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Grin1
glutamate ionotropic receptor NMDA type subunit 1
ISO
SMPDB
SMP:00681
NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
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Grin2a
glutamate ionotropic receptor NMDA type subunit 2A
ISO
SMPDB
SMP:00681
NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
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Grin3a
glutamate ionotropic receptor NMDA type subunit 3A
ISO
SMPDB
SMP:00681
NCBI chr 5:64,006,847...64,206,408
Ensembl chr 5:64,009,980...64,206,085
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Htr1a
5-hydroxytryptamine receptor 1A
ISO
SMPDB
SMP:00681
NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
G
Kcnd2
potassium voltage-gated channel subfamily D member 2
ISO
SMPDB
SMP:00681
NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728
G
Kcnip2
potassium voltage-gated channel interacting protein 2
ISO
SMPDB
SMP:00681
NCBI chr 1:244,641,147...244,664,939
Ensembl chr 1:244,641,150...244,664,874
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Oprm1
opioid receptor, mu 1
ISO
SMPDB
SMP:00681
NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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Pcsk2
proprotein convertase subtilisin/kexin type 2
ISO
SMPDB
SMP:00681
NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127
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Pomc
proopiomelanocortin
ISO
SMPDB
SMP:00681
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
G
Scn10a
sodium voltage-gated channel alpha subunit 10
ISO
SMPDB
SMP:00681
NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614
G
Scn1b
sodium voltage-gated channel beta subunit 1
ISO
SMPDB
SMP:00681
NCBI chr 1:86,353,917...86,363,820
Ensembl chr 1:86,353,917...86,363,739
G
Slc6a2
solute carrier family 6 member 2
ISO
SMPDB
SMP:00681
NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
G
Slc6a3
solute carrier family 6 member 3
ISO
SMPDB
SMP:00681
NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
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Slc6a4
solute carrier family 6 member 4
ISO
SMPDB
SMP:00681
NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
G
Hsp90aa1
heat shock protein 90 alpha family class A member 1
ISO
SMPDB
SMP:00441
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
G
Nr3c1
nuclear receptor subfamily 3, group C, member 1
ISO
SMPDB
SMP:00441
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
G
Hsp90aa1
heat shock protein 90 alpha family class A member 1
ISO
SMPDB
SMP:00632
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
G
Nr3c1
nuclear receptor subfamily 3, group C, member 1
ISO
SMPDB
SMP:00632
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all