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ONTOLOGY REPORT - ANNOTATIONS


Term:proton pump inhibitor drug pathway
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Accession:PW:0000918 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics of proton pump inhibitor (PPI), a class of compounds that block the acid secretion from parietal cells in the stomach. A representative PPI compound is omeprazole. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.


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esomeprazole pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp4a ATPase H+/K+ transporting subunit alpha JBrowse link 1 89,162,700 89,175,504 RGD:10402751
G Atp4b ATPase H+/K+ transporting subunit beta JBrowse link 16 81,136,218 81,145,131 RGD:10402751
G Car1 carbonic anhydrase 1 JBrowse link 2 88,185,204 88,227,486 RGD:10402751
G Cckbr cholecystokinin B receptor JBrowse link 1 170,262,218 170,272,298 RGD:10402751
G Chrm3 cholinergic receptor, muscarinic 3 JBrowse link 17 63,990,599 64,463,222 RGD:10402751
G Clic2 chloride intracellular channel 2 JBrowse link 20 295,338 310,363 RGD:10402751
G Gast gastrin JBrowse link 10 88,245,532 88,248,485 RGD:10402751
G Hrh2 histamine receptor H 2 JBrowse link 17 10,912,959 10,931,389 RGD:10402751
G Slc26a3 solute carrier family 26 member 3 JBrowse link 6 50,725,085 50,766,306 RGD:10402751
G Sst somatostatin JBrowse link 11 80,358,172 80,359,449 RGD:10402751
G Sstr4 somatostatin receptor 4 JBrowse link 3 142,739,781 142,741,644 RGD:10402751
esomeprazole pharmacokinetics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp4a ATPase H+/K+ transporting subunit alpha JBrowse link 1 89,162,700 89,175,504 RGD:10402751
G Atp4b ATPase H+/K+ transporting subunit beta JBrowse link 16 81,136,218 81,145,131 RGD:10402751
lansoprazole pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp4a ATPase H+/K+ transporting subunit alpha JBrowse link 1 89,162,700 89,175,504 RGD:10402751
G Atp4b ATPase H+/K+ transporting subunit beta JBrowse link 16 81,136,218 81,145,131 RGD:10402751
G Car1 carbonic anhydrase 1 JBrowse link 2 88,185,204 88,227,486 RGD:10402751
G Cckbr cholecystokinin B receptor JBrowse link 1 170,262,218 170,272,298 RGD:10402751
G Chrm3 cholinergic receptor, muscarinic 3 JBrowse link 17 63,990,599 64,463,222 RGD:10402751
G Clic2 chloride intracellular channel 2 JBrowse link 20 295,338 310,363 RGD:10402751
G Gast gastrin JBrowse link 10 88,245,532 88,248,485 RGD:10402751
G Hrh2 histamine receptor H 2 JBrowse link 17 10,912,959 10,931,389 RGD:10402751
G Slc26a3 solute carrier family 26 member 3 JBrowse link 6 50,725,085 50,766,306 RGD:10402751
G Sst somatostatin JBrowse link 11 80,358,172 80,359,449 RGD:10402751
G Sstr4 somatostatin receptor 4 JBrowse link 3 142,739,781 142,741,644 RGD:10402751
lansoprazole pharmacokinetics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp4a ATPase H+/K+ transporting subunit alpha JBrowse link 1 89,162,700 89,175,504 RGD:10402751
G Atp4b ATPase H+/K+ transporting subunit beta JBrowse link 16 81,136,218 81,145,131 RGD:10402751
omeprazole pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp4a ATPase H+/K+ transporting subunit alpha JBrowse link 1 89,162,700 89,175,504 RGD:10402751
G Atp4b ATPase H+/K+ transporting subunit beta JBrowse link 16 81,136,218 81,145,131 RGD:10402751
G Car1 carbonic anhydrase 1 JBrowse link 2 88,185,204 88,227,486 RGD:10402751
G Cckbr cholecystokinin B receptor JBrowse link 1 170,262,218 170,272,298 RGD:10402751
G Chrm3 cholinergic receptor, muscarinic 3 JBrowse link 17 63,990,599 64,463,222 RGD:10402751
G Clic2 chloride intracellular channel 2 JBrowse link 20 295,338 310,363 RGD:10402751
G Gast gastrin JBrowse link 10 88,245,532 88,248,485 RGD:10402751
G Hrh2 histamine receptor H 2 JBrowse link 17 10,912,959 10,931,389 RGD:10402751
G Slc26a3 solute carrier family 26 member 3 JBrowse link 6 50,725,085 50,766,306 RGD:10402751
G Sst somatostatin JBrowse link 11 80,358,172 80,359,449 RGD:10402751
G Sstr4 somatostatin receptor 4 JBrowse link 3 142,739,781 142,741,644 RGD:10402751
omeprazole pharmacokinetics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp4a ATPase H+/K+ transporting subunit alpha JBrowse link 1 89,162,700 89,175,504 RGD:10402751
G Atp4b ATPase H+/K+ transporting subunit beta JBrowse link 16 81,136,218 81,145,131 RGD:10402751
pantoprazole pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp4a ATPase H+/K+ transporting subunit alpha JBrowse link 1 89,162,700 89,175,504 RGD:10402751
G Atp4b ATPase H+/K+ transporting subunit beta JBrowse link 16 81,136,218 81,145,131 RGD:10402751
G Car1 carbonic anhydrase 1 JBrowse link 2 88,185,204 88,227,486 RGD:10402751
G Cckbr cholecystokinin B receptor JBrowse link 1 170,262,218 170,272,298 RGD:10402751
G Chrm3 cholinergic receptor, muscarinic 3 JBrowse link 17 63,990,599 64,463,222 RGD:10402751
G Clic2 chloride intracellular channel 2 JBrowse link 20 295,338 310,363 RGD:10402751
G Gast gastrin JBrowse link 10 88,245,532 88,248,485 RGD:10402751
G Hrh2 histamine receptor H 2 JBrowse link 17 10,912,959 10,931,389 RGD:10402751
G Slc26a3 solute carrier family 26 member 3 JBrowse link 6 50,725,085 50,766,306 RGD:10402751
G Sst somatostatin JBrowse link 11 80,358,172 80,359,449 RGD:10402751
G Sstr4 somatostatin receptor 4 JBrowse link 3 142,739,781 142,741,644 RGD:10402751
pantoprazole pharmacokinetics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp4a ATPase H+/K+ transporting subunit alpha JBrowse link 1 89,162,700 89,175,504 RGD:10402751
G Atp4b ATPase H+/K+ transporting subunit beta JBrowse link 16 81,136,218 81,145,131 RGD:10402751
rabeprazole pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp4a ATPase H+/K+ transporting subunit alpha JBrowse link 1 89,162,700 89,175,504 RGD:10402751
G Atp4b ATPase H+/K+ transporting subunit beta JBrowse link 16 81,136,218 81,145,131 RGD:10402751
G Car1 carbonic anhydrase 1 JBrowse link 2 88,185,204 88,227,486 RGD:10402751
G Cckbr cholecystokinin B receptor JBrowse link 1 170,262,218 170,272,298 RGD:10402751
G Chrm3 cholinergic receptor, muscarinic 3 JBrowse link 17 63,990,599 64,463,222 RGD:10402751
G Clic2 chloride intracellular channel 2 JBrowse link 20 295,338 310,363 RGD:10402751
G Gast gastrin JBrowse link 10 88,245,532 88,248,485 RGD:10402751
G Hrh2 histamine receptor H 2 JBrowse link 17 10,912,959 10,931,389 RGD:10402751
G Slc26a3 solute carrier family 26 member 3 JBrowse link 6 50,725,085 50,766,306 RGD:10402751
G Sst somatostatin JBrowse link 11 80,358,172 80,359,449 RGD:10402751
G Sstr4 somatostatin receptor 4 JBrowse link 3 142,739,781 142,741,644 RGD:10402751
rabeprazole pharmacokinetics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp4a ATPase H+/K+ transporting subunit alpha JBrowse link 1 89,162,700 89,175,504 RGD:10402751
G Atp4b ATPase H+/K+ transporting subunit beta JBrowse link 16 81,136,218 81,145,131 RGD:10402751

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6016
    drug pathway 393
      alimentary tract and metabolism drug pathway 78
        proton pump inhibitor drug pathway 11
          esomeprazole drug pathway + 11
          lansoprazole drug pathway + 11
          omeprazole drug pathway + 11
          pantoprazole drug pathway + 11
          rabeprazole drug pathway + 11
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.