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Term:interleukin-12 family mediated signaling pathway
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Accession:PW:0000913 term browser browse the term
Definition:Interleukin-12 family members of heterodimeric cytokines are produced by antigen presenting cells. The signaling they initiate triggers the Jak-Stat intracellular cascade and plays important roles in the regulation of T helper (Th) cell differentiation.
Synonyms:related_synonym: Il-12 family mediated signaling pathway


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interleukin-12 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf2 activating transcription factor 2 JBrowse link 3 60,721,137 60,795,951 RGD:6484113
G B2m beta-2 microglobulin JBrowse link 3 114,087,287 114,093,311 RGD:6484113
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:6484113
G Ccl4 C-C motif chemokine ligand 4 JBrowse link 10 70,870,926 70,886,357 RGD:6484113
G Ccr5 C-C motif chemokine receptor 5 JBrowse link 8 133,192,398 133,215,599 RGD:6484113
G Cd247 Cd247 molecule JBrowse link 13 83,996,045 84,071,408 RGD:6484113
G Cd3d CD3d molecule JBrowse link 8 49,282,502 49,287,095 RGD:6484113
G Cd3e CD3e molecule JBrowse link 8 49,297,604 49,309,370 RGD:6484113
G Cd3g CD3g molecule JBrowse link 8 49,274,553 49,280,943 RGD:6484113
G Cd4 Cd4 molecule JBrowse link 4 157,381,862 157,408,357 RGD:6484113
G Cd8a CD8a molecule JBrowse link 4 99,217,640 99,243,352 RGD:6484113
G Cd8b CD8b molecule JBrowse link 4 99,185,960 99,201,887 RGD:6484113
G Eomes eomesodermin JBrowse link 8 127,144,367 127,152,618 RGD:6484113
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:6484113
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6484113
G Gadd45b growth arrest and DNA-damage-inducible, beta JBrowse link 7 11,646,283 11,648,338 RGD:6484113
G Gadd45g growth arrest and DNA-damage-inducible, gamma JBrowse link 17 13,391,474 13,393,219 RGD:6484113
G Gzma granzyme A JBrowse link 2 44,968,846 44,981,436 RGD:6484113
G Gzmbl2 Granzyme B-like 2 JBrowse link 15 36,469,318 36,472,393 RGD:6484113
G Hlx H2.0-like homeobox JBrowse link 13 102,637,967 102,643,376 RGD:6484113
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6484113
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:6484113
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6484113
G Il12rb1 interleukin 12 receptor subunit beta 1 JBrowse link 16 20,370,722 20,383,576 RGD:6484113
G Il12rb2 interleukin 12 receptor subunit beta 2 JBrowse link 4 98,049,195 98,141,562 RGD:6484113
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:6484113
G Il18r1 interleukin 18 receptor 1 JBrowse link 9 47,184,404 47,217,403 RGD:6484113
G Il18rap interleukin 18 receptor accessory protein JBrowse link 9 47,225,543 47,255,805 RGD:6484113
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6484113
G Il1r1 interleukin 1 receptor type 1 JBrowse link 9 46,962,291 47,038,139 RGD:6484113
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6484113
G Il2ra interleukin 2 receptor subunit alpha JBrowse link 17 70,500,672 70,547,929 RGD:6484113
G Il2rb interleukin 2 receptor subunit beta JBrowse link 7 119,701,338 119,716,238 RGD:6484113
G Il2rg interleukin 2 receptor subunit gamma JBrowse link X 71,165,378 71,169,078 RGD:6484113
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6484113
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:6484113
G Lck LCK proto-oncogene, Src family tyrosine kinase JBrowse link 5 147,750,976 147,779,627 RGD:6484113
G Map2k3 mitogen activated protein kinase kinase 3 JBrowse link 10 45,089,455 45,110,802 RGD:6484113
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:6484113
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6484113
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6484113
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6484113
G Nfkb2 nuclear factor kappa B subunit 2 JBrowse link 1 266,050,634 266,059,277 RGD:6484113
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6484113
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:6484113
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:6484113
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha JBrowse link 14 100,311,224 100,360,879 RGD:6484113
G Rab7a RAB7A, member RAS oncogene family JBrowse link 4 119,910,461 119,963,065 RGD:6484113
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6484113
G Relb RELB proto-oncogene, NF-kB subunit JBrowse link 1 80,517,081 80,545,019 RGD:6484113
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:6484113
G RT1-Da RT1 class II, locus Da JBrowse link 20 4,127,644 4,132,616 RGD:6484113
G RT1-Db1 RT1 class II, locus Db1 JBrowse link 20 4,087,621 4,097,190 RGD:6484113
G Socs1 suppressor of cytokine signaling 1 JBrowse link 10 4,956,795 4,958,472 RGD:6484113
G Sphk2 sphingosine kinase 2 JBrowse link 1 101,692,972 101,700,604 RGD:6484113
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6484113
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6484113
G Stat4 signal transducer and activator of transcription 4 JBrowse link 9 54,340,649 54,457,753 RGD:6484113
G Stat5a signal transducer and activator of transcription 5A JBrowse link 10 88,764,732 88,789,060 RGD:6484113
G Stat6 signal transducer and activator of transcription 6 JBrowse link 7 70,946,228 70,963,542 RGD:6484113
G Tbx21 T-box transcription factor 21 JBrowse link 10 85,032,799 85,049,331 RGD:6484113
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:6484113
interleukin-23 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox12b arachidonate 12-lipoxygenase, 12R type JBrowse link 10 55,744,646 55,756,524 RGD:6484113
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6484113
G Cd3e CD3e molecule JBrowse link 8 49,297,604 49,309,370 RGD:6484113
G Cd4 Cd4 molecule JBrowse link 4 157,381,862 157,408,357 RGD:6484113
G Cxcl1 C-X-C motif chemokine ligand 1 JBrowse link 14 18,743,678 18,745,457 RGD:6484113
G Cxcl9 C-X-C motif chemokine ligand 9 JBrowse link 14 17,228,832 17,233,743 RGD:6484113
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6484113
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6484113
G Il12rb1 interleukin 12 receptor subunit beta 1 JBrowse link 16 20,370,722 20,383,576 RGD:6484113
G Il17f interleukin 17F JBrowse link 9 26,885,702 26,897,219 RGD:6484113
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:6484113
G Il18r1 interleukin 18 receptor 1 JBrowse link 9 47,184,404 47,217,403 RGD:6484113
G Il18rap interleukin 18 receptor accessory protein JBrowse link 9 47,225,543 47,255,805 RGD:6484113
G Il19 interleukin 19 JBrowse link 13 47,663,592 47,677,869 RGD:6484113
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6484113
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6484113
G Il23a interleukin 23 subunit alpha JBrowse link 7 2,710,609 2,712,723 RGD:6484113
G Il23r interleukin 23 receptor JBrowse link 4 98,203,788 98,306,729 RGD:6484113
G Il24 interleukin 24 JBrowse link 13 47,618,451 47,623,849 RGD:6484113
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6484113
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:6484113
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6484113
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6484113
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6484113
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6484113
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6484113
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:6484113
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6484113
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6484113
G Stat4 signal transducer and activator of transcription 4 JBrowse link 9 54,340,649 54,457,753 RGD:6484113
G Stat5a signal transducer and activator of transcription 5A JBrowse link 10 88,764,732 88,789,060 RGD:6484113
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6484113
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:6484113
interleukin-27 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ebi3 Epstein-Barr virus induced 3 JBrowse link 9 11,110,874 11,114,843 RGD:6484113
G Gata3 GATA binding protein 3 JBrowse link 17 72,419,752 72,452,043 RGD:6484113
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6484113
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:6484113
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6484113
G Il12rb1 interleukin 12 receptor subunit beta 1 JBrowse link 16 20,370,722 20,383,576 RGD:6484113
G Il12rb2 interleukin 12 receptor subunit beta 2 JBrowse link 4 98,049,195 98,141,562 RGD:6484113
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:6484113
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6484113
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6484113
G Il27 interleukin 27 JBrowse link 1 198,003,615 198,010,112 RGD:6484113
G Il27ra interleukin 27 receptor subunit alpha JBrowse link 19 25,151,835 25,163,995 RGD:6484113
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6484113
G Il6st interleukin 6 signal transducer JBrowse link 2 44,279,199 44,319,427 RGD:6484113
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:6484113
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:6484113
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6484113
G Stat2 signal transducer and activator of transcription 2 JBrowse link 7 2,691,064 2,707,530 RGD:6484113
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6484113
G Stat4 signal transducer and activator of transcription 4 JBrowse link 9 54,340,649 54,457,753 RGD:6484113
G Stat5a signal transducer and activator of transcription 5A JBrowse link 10 88,764,732 88,789,060 RGD:6484113
G Tbx21 T-box transcription factor 21 JBrowse link 10 85,032,799 85,049,331 RGD:6484113
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6484113
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6484113
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:6484113

Term paths to the root
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Term Annotations click to browse term
  pathway 6016
    signaling pathway 2585
      signaling pathway pertinent to immunity 779
        cytokine mediated signaling pathway 473
          Interleukin mediated signaling pathway 245
            interleukin-12 family mediated signaling pathway 86
              interleukin-12 signaling pathway 62
              interleukin-23 signaling pathway 35
              interleukin-27 signaling pathway 25
              interleukin-35 signaling pathway 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.