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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:interleukin-4 signaling pathway
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Accession:PW:0000912 term browser browse the term
Definition:Interleukin-4 is a member of the interleukin 2 family of cytokines whose signaling is important for the differentiation of naive T helper cells.
Synonyms:exact_synonym: Il-4 signaling pathway
 related_synonym: interleukin-4-mediated signaling pathway


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interleukin-4 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase ISO PID PID:200022 NCBI chr27:37,064,107...37,073,791
Ensembl chr27:37,064,080...37,073,789 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 ISO PID PID:200022 NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193 		JBrowse link
G ALOX15 arachidonate 15-lipoxygenase ISO PID PID:200022 NCBI chr 5:31,883,544...31,891,357
Ensembl chr 5:31,882,501...32,038,119 		JBrowse link
G ARG1 arginase 1 ISO PID PID:200022 NCBI chr12:242,717...255,736
Ensembl chr12:242,714...255,305 		JBrowse link
G BCL6 BCL6 transcription repressor ISO PID PID:200022 NCBI chr34:20,112,302...20,135,705
Ensembl chr34:20,113,322...20,124,704 		JBrowse link
G CBL Cbl proto-oncogene ISO PID PID:200022 NCBI chr 5:14,600,409...14,676,974
Ensembl chr 5:14,607,013...14,676,956 		JBrowse link
G CCL17 C-C motif chemokine ligand 17 ISO PID PID:200022 NCBI chr 2:59,001,463...59,014,347
Ensembl chr 2:59,001,464...59,005,230 		JBrowse link
G CCL26 C-C motif chemokine ligand 26 ISO PID PID:200022 NCBI chr 6:7,151,352...7,154,509
Ensembl chr 6:7,151,212...7,154,726 		JBrowse link
G CD40LG CD40 ligand ISO PID PID:200022 NCBI chr  X:107,001,421...107,023,007
Ensembl chr  X:107,010,890...107,023,006 		JBrowse link
G CEBPB CCAAT enhancer binding protein beta ISO PID PID:200022 NCBI chr24:36,661,294...36,663,162
Ensembl chr24:36,661,616...36,662,656 		JBrowse link
G COL1A1 collagen type I alpha 1 chain ISO PID PID:200022 NCBI chr 9:26,183,852...26,199,927
Ensembl chr 9:26,183,852...26,199,927 		JBrowse link
G COL1A2 collagen type I alpha 2 chain ISO PID PID:200022 NCBI chr14:19,883,731...19,919,527
Ensembl chr14:19,883,868...19,919,527 		JBrowse link
G DOK2 docking protein 2 ISO PID PID:200022 NCBI chr25:35,328,767...35,338,712
Ensembl chr25:35,334,176...35,339,175 		JBrowse link
G EGR2 early growth response 2 ISO PID PID:200022 NCBI chr 4:14,705,384...14,810,130
Ensembl chr 4:14,706,600...14,709,497 		JBrowse link
G ETS1 ETS proto-oncogene 1, transcription factor ISO PID PID:200022 NCBI chr 5:6,059,023...6,189,516
Ensembl chr 5:6,058,935...6,186,232 		JBrowse link
G FCER2 Fc epsilon receptor II ISO PID PID:200022 NCBI chr20:52,451,637...52,460,045
Ensembl chr20:52,449,922...52,457,805 		JBrowse link
G FES FES proto-oncogene, tyrosine kinase ISO PID PID:200022 NCBI chr 3:53,346,975...53,356,547
Ensembl chr 3:53,347,012...53,356,516 		JBrowse link
G GRB2 growth factor receptor bound protein 2 ISO PID PID:200022 NCBI chr 9:5,108,128...5,182,091
Ensembl chr 9:5,117,164...5,180,296 		JBrowse link
G GTF3A general transcription factor IIIA ISO PID PID:200022 NCBI chr25:12,171,058...12,183,491
Ensembl chr25:12,166,981...12,230,467 		JBrowse link
G HMGA1 high mobility group AT-hook 1 ISO PID PID:200022 NCBI chr12:3,528,818...3,538,533
Ensembl chr12:3,533,102...3,538,533 		JBrowse link
G IL10 interleukin 10 ISO PID PID:200022 NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057 		JBrowse link
G IL13RA1 interleukin 13 receptor subunit alpha 1 ISO PID PID:200022 NCBI chr  X:90,925,497...90,981,855
Ensembl chr  X:90,924,801...90,979,963 		JBrowse link
G IL13RA2 interleukin 13 receptor subunit alpha 2 ISO PID PID:200022 NCBI chr  X:87,747,373...87,776,797
Ensembl chr  X:87,747,373...87,776,798 		JBrowse link
G IL2RG interleukin 2 receptor subunit gamma ISO PID PID:200022 NCBI chr  X:55,480,846...55,488,485
Ensembl chr  X:55,481,092...55,484,751 		JBrowse link
G IL4 interleukin 4 ISO PID PID:200022 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
G IL4R interleukin 4 receptor ISO PID PID:200022 NCBI chr 6:19,254,183...19,280,973
Ensembl chr 6:19,254,487...19,389,291 		JBrowse link
G IL5 interleukin 5 ISO PID PID:200022 NCBI chr11:20,825,469...20,827,269
Ensembl chr11:20,825,469...20,827,269 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D ISO PID PID:200022 NCBI chr25:44,612,146...44,731,347
Ensembl chr25:44,611,523...44,730,200 		JBrowse link
G IRF4 interferon regulatory factor 4 ISO PID PID:200022 NCBI chr35:760,367...782,314
Ensembl chr35:767,011...781,339 		JBrowse link
G IRS1 insulin receptor substrate 1 ISO PID PID:200022 NCBI chr25:39,624,554...39,687,991 JBrowse link
G IRS2 insulin receptor substrate 2 ISO PID PID:200022 NCBI chr22:58,197,016...58,229,026
Ensembl chr22:58,223,387...58,227,535 		JBrowse link
G ITGB3 integrin subunit beta 3 ISO PID PID:200022 NCBI chr 9:9,179,667...9,231,061
Ensembl chr 9:9,182,562...9,231,451 		JBrowse link
G JAK1 Janus kinase 1 ISO PID PID:200022 NCBI chr 5:45,251,653...45,408,571
Ensembl chr 5:45,251,653...45,408,571 		JBrowse link
G JAK2 Janus kinase 2 ISO PID PID:200022 NCBI chr 1:93,321,055...93,438,898
Ensembl chr 1:93,142,635...93,435,997 		JBrowse link
G JAK3 Janus kinase 3 ISO PID PID:200022 NCBI chr20:45,051,135...45,068,445
Ensembl chr20:45,050,526...45,072,805 		JBrowse link
G LTA lymphotoxin alpha ISO PID PID:200022 NCBI chr12:1,070,608...1,073,053
Ensembl chr12:1,071,192...1,073,067 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 ISO PID PID:200022 NCBI chr12:5,145,647...5,221,558
Ensembl chr12:5,146,037...5,220,603 		JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO PID PID:200022 NCBI chr 2:84,818,893...84,939,283
Ensembl chr 2:84,787,708...84,939,114 		JBrowse link
G MYB MYB proto-oncogene, transcription factor ISO PID PID:200022 NCBI chr 1:27,908,309...27,991,984
Ensembl chr 1:27,908,364...27,991,969 		JBrowse link
G MYBL1 MYB proto-oncogene like 1 ISO PID PID:200022 NCBI chr29:16,155,867...16,192,814
Ensembl chr29:16,157,821...16,192,808 		JBrowse link
G OPRM1 opioid receptor mu 1 ISO PID PID:200022 NCBI chr 1:43,972,915...44,037,477
Ensembl chr 1:43,972,219...44,141,238 		JBrowse link
G PARP14 poly(ADP-ribose) polymerase family member 14 ISO PID PID:200022 NCBI chr33:25,763,282...25,798,284
Ensembl chr33:25,763,255...25,798,198 		JBrowse link
G PIGR polymeric immunoglobulin receptor ISO PID PID:200022 NCBI chr 7:6,070,407...6,087,605
Ensembl chr 7:6,070,407...6,087,605 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO PID PID:200022 NCBI chr34:12,600,140...12,681,905
Ensembl chr34:12,600,233...12,675,910 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200022 NCBI chr 2:53,447,802...53,527,563
Ensembl chr 2:53,448,286...53,524,970 		JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 ISO PID PID:200022 NCBI chr27:38,084,976...38,101,552
Ensembl chr27:38,084,980...38,101,937 		JBrowse link
G RETNLB resistin like beta ISO PID PID:200022 NCBI chr33:13,980,710...13,982,586 JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 ISO PID PID:200022 NCBI chr 9:34,387,084...34,590,603
Ensembl chr 9:34,387,091...34,425,292 		JBrowse link
G SELP selectin P ISO PID PID:200022 NCBI chr 7:28,956,428...28,997,266
Ensembl chr 7:28,958,486...28,996,313 		JBrowse link
G SHC1 SHC adaptor protein 1 ISO PID PID:200022 NCBI chr 7:42,501,829...42,509,613
Ensembl chr 7:42,500,185...42,508,276 		JBrowse link
G SOCS1 suppressor of cytokine signaling 1 ISO PID PID:200022 NCBI chr 6:31,511,003...31,511,995
Ensembl chr 6:31,509,268...31,511,557 		JBrowse link
G SOCS3 suppressor of cytokine signaling 3 ISO PID PID:200022 NCBI chr 9:2,859,267...2,859,944 JBrowse link
G SOCS5 suppressor of cytokine signaling 5 ISO PID PID:200022 NCBI chr10:48,916,446...48,977,183
Ensembl chr10:48,972,842...48,974,452 		JBrowse link
G SP1 Sp1 transcription factor ISO PID PID:200022 NCBI chr27:1,802,587...1,861,187
Ensembl chr27:1,805,184...1,847,226 		JBrowse link
G SPI1 Spi-1 proto-oncogene ISO PID PID:200022 NCBI chr18:42,253,849...42,269,497
Ensembl chr18:42,253,811...42,269,727 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A ISO PID PID:200022 NCBI chr 9:20,616,041...20,638,523
Ensembl chr 9:20,617,151...20,638,103 		JBrowse link
G STAT5B signal transducer and activator of transcription 5B ISO PID PID:200022 NCBI chr 9:20,647,712...20,718,453
Ensembl chr 9:20,691,483...20,716,485 		JBrowse link
G STAT6 signal transducer and activator of transcription 6 ISO PID PID:200022 NCBI chr10:1,232,515...1,247,011
Ensembl chr10:1,233,691...1,247,075 		JBrowse link
G TFF3 trefoil factor 3 ISO PID PID:200022 NCBI chr31:36,638,762...36,641,696 JBrowse link
G THY1 Thy-1 cell surface antigen ISO PID PID:200022 NCBI chr 5:14,503,902...14,509,113
Ensembl chr 5:14,503,902...14,509,113 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4052
    signaling pathway 1939
      signaling pathway pertinent to immunity 418
        cytokine mediated signaling pathway 334
          Interleukin mediated signaling pathway 247
            interleukin-2 family mediated signaling pathway 99
              interleukin-4 signaling pathway 60
paths to the root