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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:interleukin-4 signaling pathway
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Accession:PW:0000912 term browser browse the term
Definition:Interleukin-4 is a member of the interleukin 2 family of cytokines whose signaling is important for the differentiation of naive T helper cells.
Synonyms:exact_synonym: Il-4 signaling pathway
 related_synonym: interleukin-4-mediated signaling pathway

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interleukin-4 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200022 NCBI chrNW_004955538:3,208,711...3,224,386
Ensembl chrNW_004955538:3,208,710...3,229,904 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase ISO PID PID:200022 NCBI chrNW_004955467:10,032,792...10,039,789 JBrowse link
G Arg1 arginase 1 ISO PID PID:200022 NCBI chrNW_004955436:12,235,767...12,247,817
Ensembl chrNW_004955436:12,235,767...12,251,972 		JBrowse link
G Bcl6 BCL6 transcription repressor ISO PID PID:200022 NCBI chrNW_004955420:19,998,960...20,021,200
Ensembl chrNW_004955420:19,998,742...20,022,259 		JBrowse link
G Cbl Cbl proto-oncogene ISO PID PID:200022 NCBI chrNW_004955412:20,307,011...20,388,539
Ensembl chrNW_004955412:20,307,011...20,388,539 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 ISO PID PID:200022 NCBI chrNW_004955433:15,052,616...15,054,732
Ensembl chrNW_004955433:15,053,061...15,054,572 		JBrowse link
G Ccl26 C-C motif chemokine ligand 26 ISO PID PID:200022 NCBI chrNW_004955456:14,554,583...14,558,967 JBrowse link
G Cd40lg CD40 ligand ISO PID PID:200022 NCBI chrNW_004955489:8,465,571...8,477,714
Ensembl chrNW_004955489:8,465,164...8,477,746 		JBrowse link
G Cebpb CCAAT enhancer binding protein beta ISO PID PID:200022 NCBI chrNW_004955445:8,060,432...8,061,289 JBrowse link
G Col1a1 collagen type I alpha 1 chain ISO PID PID:200022 NCBI chrNW_004955451:11,468,156...11,484,410
Ensembl chrNW_004955451:11,468,290...11,483,073 		JBrowse link
G Col1a2 collagen type I alpha 2 chain ISO PID PID:200022 NCBI chrNW_004955432:11,127,961...11,164,145
Ensembl chrNW_004955432:11,128,112...11,163,302 		JBrowse link
G Dok2 docking protein 2 ISO PID PID:200022 NCBI chrNW_004955403:45,410,689...45,421,366
Ensembl chrNW_004955403:45,410,279...45,415,067 		JBrowse link
G Egr2 early growth response 2 ISO PID PID:200022 NCBI chrNW_004955425:16,055,748...16,068,429
Ensembl chrNW_004955425:16,055,748...16,060,048 		JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor ISO PID PID:200022 NCBI chrNW_004955412:29,433,730...29,602,389
Ensembl chrNW_004955412:29,432,482...29,545,580 		JBrowse link
G Fcer2 Fc fragment of IgE receptor II ISO PID PID:200022 NCBI chrNW_004955563:1,587,471...1,596,707
Ensembl chrNW_004955563:1,587,396...1,596,063 		JBrowse link
G Fes FES proto-oncogene, tyrosine kinase ISO PID PID:200022 NCBI chrNW_004955416:14,948,121...14,959,035
Ensembl chrNW_004955416:14,948,123...14,960,005 		JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO PID PID:200022 NCBI chrNW_004955553:2,186,590...2,258,964
Ensembl chrNW_004955553:2,186,590...2,259,456 		JBrowse link
G Gtf3a general transcription factor IIIA ISO PID PID:200022 NCBI chrNW_004955497:6,836,568...6,852,177
Ensembl chrNW_004955497:6,842,960...6,851,835 		JBrowse link
G Hmga1 high mobility group AT-hook 1 ISO PID PID:200022 NCBI chrNW_004955437:2,478,414...2,486,809
Ensembl chrNW_004955437:2,478,414...2,486,809 		JBrowse link
G Il10 interleukin 10 ISO PID PID:200022 NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 ISO PID PID:200022 NCBI chrNW_004955534:1,157,758...1,205,158
Ensembl chrNW_004955534:1,160,340...1,204,911 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 ISO PID PID:200022 NCBI chrNW_004955490:708,144...758,195
Ensembl chrNW_004955490:709,446...758,272 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma ISO PID PID:200022 NCBI chrNW_004955475:10,676,592...10,680,565
Ensembl chrNW_004955475:10,676,870...10,680,517 		JBrowse link
G Il4 interleukin 4 ISO PID PID:200022 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G Il4r interleukin 4 receptor ISO PID PID:200022 NCBI chrNW_004955493:5,546,340...5,580,745
Ensembl chrNW_004955493:5,545,944...5,582,422 		JBrowse link
G Il5 interleukin 5 ISO PID PID:200022 NCBI chrNW_004955408:3,937,128...3,951,784
Ensembl chrNW_004955408:3,937,894...3,939,358 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D ISO PID PID:200022 NCBI chrNW_004955453:2,938,659...3,037,211
Ensembl chrNW_004955453:2,938,659...3,037,211 		JBrowse link
G Irf4 interferon regulatory factor 4 ISO PID PID:200022 NCBI chrNW_004955465:12,497,534...12,512,529
Ensembl chrNW_004955465:12,497,462...12,513,106 		JBrowse link
G Irs1 insulin receptor substrate 1 ISO PID PID:200022 NCBI chrNW_004955453:7,685,715...7,742,262
Ensembl chrNW_004955453:7,685,715...7,742,262 		JBrowse link
G Irs2 insulin receptor substrate 2 ISO PID PID:200022 NCBI chrNW_004955404:2,531,484...2,555,383
Ensembl chrNW_004955404:2,531,484...2,555,689 		JBrowse link
G Itgb3 integrin subunit beta 3 ISO PID PID:200022 NCBI chrNW_004955478:9,788,192...9,830,254
Ensembl chrNW_004955478:9,788,149...9,823,746 		JBrowse link
G Jak1 Janus kinase 1 ISO PID PID:200022 NCBI chrNW_004955423:25,501,989...25,581,826
Ensembl chrNW_004955423:25,524,075...25,580,604 		JBrowse link
G Jak2 Janus kinase 2 ISO PID PID:200022 NCBI chrNW_004955434:9,227,897...9,341,208
Ensembl chrNW_004955434:9,227,595...9,341,208 		JBrowse link
G Jak3 Janus kinase 3 ISO PID PID:200022 NCBI chrNW_004955524:3,399,895...3,412,018
Ensembl chrNW_004955524:3,401,642...3,411,643 		JBrowse link
G Lta lymphotoxin alpha ISO PID PID:200022 NCBI chrNW_004955437:114,216...116,003
Ensembl chrNW_004955437:114,640...115,529 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 ISO PID PID:200022 NCBI chrNW_004955437:3,836,331...3,884,083
Ensembl chrNW_004955437:3,838,232...3,884,083 		JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO PID PID:200022 NCBI chrNW_004955486:2,487,642...2,599,694
Ensembl chrNW_004955486:2,487,642...2,599,694 		JBrowse link
G Myb MYB proto-oncogene, transcription factor ISO PID PID:200022 NCBI chrNW_004955439:1,523,516...1,560,185
Ensembl chrNW_004955439:1,521,292...1,560,220 		JBrowse link
G Mybl1 MYB proto-oncogene like 1 ISO PID PID:200022 NCBI chrNW_004955444:12,589,464...12,620,602
Ensembl chrNW_004955444:12,589,464...12,620,663 		JBrowse link
G Oprm1 opioid receptor mu 1 ISO PID PID:200022 NCBI chrNW_004955439:7,870,563...7,923,817
Ensembl chrNW_004955439:7,757,569...7,923,817 		JBrowse link
G Parp14 poly(ADP-ribose) polymerase family member 14 ISO PID PID:200022 NCBI chrNW_004955427:21,878,980...21,929,097
Ensembl chrNW_004955427:21,879,740...21,927,883 		JBrowse link
G Pigr polymeric immunoglobulin receptor ISO PID PID:200022 NCBI chrNW_004955406:42,456,450...42,474,489
Ensembl chrNW_004955406:42,453,080...42,474,694 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO PID PID:200022 NCBI chrNW_004955420:8,355,415...8,427,024
Ensembl chrNW_004955420:8,356,353...8,427,024 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200022 NCBI chrNW_004955446:1,020,707...1,098,327
Ensembl chrNW_004955446:1,020,043...1,098,820 		JBrowse link
G Ptpn6 protein tyrosine phosphatase non-receptor type 6 ISO PID PID:200022 NCBI chrNW_004955413:4,525,954...4,547,177
Ensembl chrNW_004955413:4,525,954...4,547,177 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 ISO PID PID:200022 NCBI chrNW_004955451:3,181,085...3,225,610 JBrowse link
G Selp selectin P ISO PID PID:200022 NCBI chrNW_004955462:7,658,371...7,692,870
Ensembl chrNW_004955462:7,652,437...7,693,994 		JBrowse link
G Shc1 SHC adaptor protein 1 ISO PID PID:200022 NCBI chrNW_004955545:1,468,391...1,479,209
Ensembl chrNW_004955545:1,468,391...1,476,814 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 ISO PID PID:200022 NCBI chrNW_004955442:7,321,337...7,323,109
Ensembl chrNW_004955442:7,321,337...7,323,109 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO PID PID:200022 NCBI chrNW_004955506:4,222,455...4,225,563
Ensembl chrNW_004955506:4,222,455...4,225,563 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 ISO PID PID:200022 NCBI chrNW_004955441:13,593,342...13,657,389
Ensembl chrNW_004955441:13,593,342...13,657,389 		JBrowse link
G Sp1 Sp1 transcription factor ISO PID PID:200022 NCBI chrNW_004955458:644,435...677,360
Ensembl chrNW_004955458:644,378...677,441 		JBrowse link
G Spi1 Spi-1 proto-oncogene ISO PID PID:200022 NCBI chrNW_004955422:873,735...886,560
Ensembl chrNW_004955422:873,735...886,560 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A ISO PID PID:200022 NCBI chrNW_004955451:16,305,363...16,319,219 JBrowse link
G Stat5b signal transducer and activator of transcription 5B ISO PID PID:200022 NCBI chrNW_004955451:16,253,645...16,295,337 JBrowse link
G Stat6 signal transducer and activator of transcription 6 ISO PID PID:200022 NCBI chrNW_004955458:4,833,417...4,847,956
Ensembl chrNW_004955458:4,833,515...4,843,273 		JBrowse link
G Tff3 trefoil factor 3 ISO PID PID:200022 NCBI chrNW_004955407:39,398,534...39,401,085
Ensembl chrNW_004955407:39,398,074...39,401,248 		JBrowse link
G Thy1 Thy-1 cell surface antigen ISO PID PID:200022 NCBI chrNW_004955412:20,480,284...20,484,958
Ensembl chrNW_004955412:20,480,284...20,484,958 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3930
    signaling pathway 1892
      signaling pathway pertinent to immunity 398
        cytokine mediated signaling pathway 317
          Interleukin mediated signaling pathway 234
            interleukin-2 family mediated signaling pathway 97
              interleukin-4 signaling pathway 58
paths to the root