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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:interleukin-1 signaling pathway
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Accession:PW:0000883 term browser browse the term
Definition:Interleukin-1 signaling, primarily via interleukin-1beta, plays important roles in innate and adaptive immune responses. Binding of the processed cytokine to its receptor allows for the recruitment of several accessory and adaptor proteins leading to the activation of NF-kappaB and MAPK signaling cascades. A natural receptor antagonist and a decoy receptor act as regulators of interleukin-1alpha and beta.
Synonyms:related_synonym: Il-1 signaling pathway;   Interleukin-1 signaling;   interleukin-1-mediated signaling pathway
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interleukin-1 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP1 caspase 1, apoptosis-related cysteine peptidase ISO PID
RGD		 PMID:19302047 PMID:20303873 PID:200089 RGD:5490210 RGD:5490211 NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex ISO PID PID:200089 NCBI chr14:111,316,178...111,351,669
Ensembl chr14:111,315,141...111,351,868 		JBrowse link
G ERC1 ELKS/RAB6-interacting/CAST family member 1 ISO PID PID:200089 NCBI chr 5:68,223,722...68,608,705
Ensembl chr 5:68,223,729...68,608,703 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta ISO PID PID:200089 NCBI chr17:11,289,607...11,348,557
Ensembl chr17:11,289,690...11,348,549 		JBrowse link
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO PID PID:200089 NCBI chr  X:125,035,575...125,056,445
Ensembl chr  X:125,036,508...125,056,453 		JBrowse link
G IL1A interleukin 1 alpha ISO PID
RGD		 PMID:20081871 PID:200089 RGD:5490209 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119 		JBrowse link
G IL1R1 interleukin 1 receptor type 1 ISO RGD
PID		 PMID:20081871 PMID:20967881 PID:200089 RGD:5130945 RGD:5490209 NCBI chr 3:52,192,912...52,334,734
Ensembl chr 3:52,192,915...52,288,485 		JBrowse link
G IL1R2 interleukin 1 receptor type 2 ISO PID
RGD		 PMID:20081871 PID:200089 RGD:5490209 NCBI chr 3:52,367,434...52,406,393
Ensembl chr 3:52,367,437...52,406,334 		JBrowse link
G IL1RAP interleukin 1 receptor accessory protein ISO RGD PMID:20081871 RGD:5490209 NCBI chr13:127,933,239...128,071,984
Ensembl chr13:127,933,693...128,043,480 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO PID
RGD		 PMID:20081871 PID:200089 RGD:5490209
G IRAK1 interleukin 1 receptor associated kinase 1 ISO PID
RGD		 PMID:18535784 PMID:20086235 PID:200089 RGD:5490215 RGD:5490218 NCBI chr  X:124,717,604...124,724,855
Ensembl chr  X:124,717,612...124,724,860 		JBrowse link
G IRAK2 interleukin 1 receptor associated kinase 2 ISO RGD PMID:20086235 RGD:5490215 NCBI chr13:66,350,606...66,416,834
Ensembl chr13:66,350,606...66,416,827 		JBrowse link
G IRAK3 interleukin 1 receptor associated kinase 3 ISO PID PID:200089 NCBI chr 5:30,524,704...30,601,067
Ensembl chr 5:30,526,793...30,609,921 		JBrowse link
G IRAK4 interleukin 1 receptor associated kinase 4 ISO PID
RGD		 PMID:18535784 PMID:20086235 PID:200089 RGD:5490215 RGD:5490218 NCBI chr 5:74,842,184...74,858,125
Ensembl chr 5:74,834,600...74,859,344 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200089 NCBI chr 6:153,686,425...153,687,635
Ensembl chr 6:153,685,682...153,687,636 		JBrowse link
G LOC110258578 interleukin-1 beta-like ISO PID
RGD		 PMID:20081871 PID:200089 RGD:5490209
G MAP2K6 mitogen-activated protein kinase kinase 6 ISO PID PID:200089 NCBI chr12:10,891,445...11,018,617
Ensembl chr12:10,894,966...11,018,641 		JBrowse link
G MAP3K3 mitogen-activated protein kinase kinase kinase 3 ISO PID PID:200089 NCBI chr12:15,228,979...15,298,784
Ensembl chr12:15,230,182...15,298,784 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 ISO PID
RGD		 PMID:18535784 PMID:20086235 PID:200089 RGD:5490215 RGD:5490218 NCBI chr 1:58,482,046...58,548,087
Ensembl chr 1:58,481,956...58,548,057 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 ISO PID PID:200089 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor ISO PID
RGD		 PMID:18535784 PMID:20086235 PID:200089 RGD:5490215 RGD:5490218 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 ISO PID PID:200089 NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691 		JBrowse link
G NLRP1 NLR family pyrin domain containing 1 ISO RGD PMID:20303873 RGD:5490211 NCBI chr12:51,479,968...51,495,540 JBrowse link
G NLRP3 NLR family pyrin domain containing 3 ISO RGD PMID:19302047 PMID:20303873 RGD:5490210 RGD:5490211 NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,243...56,977,228 		JBrowse link
G PELI1 pellino E3 ubiquitin protein ligase 1 ISO RGD PMID:20086235 RGD:5490215 NCBI chr 3:77,740,460...77,796,911
Ensembl chr 3:77,713,489...77,796,914 		JBrowse link
G PELI2 pellino E3 ubiquitin protein ligase family member 2 ISO RGD PMID:20086235 RGD:5490215 NCBI chr 1:185,397,807...185,604,160
Ensembl chr 1:185,397,812...185,599,780 		JBrowse link
G PELI3 pellino E3 ubiquitin protein ligase family member 3 ISO RGD PMID:20086235 RGD:5490215 NCBI chr 2:5,950,552...5,959,786
Ensembl chr 2:5,948,849...5,959,734 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO PID PID:200089 NCBI chr13:117,193,935...117,282,151
Ensembl chr13:117,180,544...117,274,587 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200089 NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,511,521...46,523,609 		JBrowse link
G PRKCI protein kinase C iota ISO PID PID:200089 NCBI chr13:108,913,018...108,997,934
Ensembl chr13:108,913,173...108,997,931 		JBrowse link
G PRKCZ protein kinase C zeta ISO PID PID:200089 NCBI chr 6:64,073,343...64,159,187
Ensembl chr 6:64,068,577...64,163,472 		JBrowse link
G PYCARD PYD and CARD domain containing ISO RGD PMID:19302047 PMID:20303873 RGD:5490210 RGD:5490211 NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,099...17,307,786 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO PID PID:200089 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469 		JBrowse link
G SIGIRR single Ig and TIR domain containing ISO RGD PMID:20081871 RGD:5490209 NCBI chr 2:223,691...226,542
Ensembl chr 2:223,520...230,741 		JBrowse link
G SQSTM1 sequestosome 1 ISO PID PID:200089 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938 		JBrowse link
G TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 ISO PID
RGD		 PMID:18535784 PMID:20086235 PID:200089 RGD:5490215 RGD:5490218 NCBI chr 5:8,827,363...8,852,814
Ensembl chr 5:8,826,840...8,852,776 		JBrowse link
G TAB2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 ISO PID
RGD		 PMID:18535784 PMID:20086235 PID:200089 RGD:5490215 RGD:5490218 NCBI chr 1:16,533,364...16,611,879
Ensembl chr 1:16,533,285...16,611,884 		JBrowse link
G TAB3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 ISO RGD PMID:18535784 RGD:5490218 NCBI chr  X:26,632,547...26,729,039
Ensembl chr  X:26,632,551...26,729,051 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 ISO PID PID:200089 NCBI chr 2:119,758,622...119,778,650 JBrowse link
G TOLLIP toll interacting protein ISO PID
RGD		 PMID:18535784 PID:200089 RGD:5490218 NCBI chr 2:852,198...864,337
Ensembl chr 2:851,512...864,483 		JBrowse link
G TRAF6 TNF receptor associated factor 6 ISO RGD
PID		 PMID:18535784 PMID:20086235 PMID:20967881 PID:200089 RGD:5130945 RGD:5490215 RGD:5490218 NCBI chr 2:24,602,749...24,628,263
Ensembl chr 2:24,602,804...24,626,072 		JBrowse link
G UBE2N ubiquitin conjugating enzyme E2 N ISO PID
RGD		 PMID:18535784 PMID:20086235 PID:200089 RGD:5490215 RGD:5490218 NCBI chr 5:89,673,306...89,716,345
Ensembl chr 5:89,673,573...89,714,281 		JBrowse link
G UBE2V1 ubiquitin conjugating enzyme E2 V1 ISO PID
RGD		 PMID:18535784 PMID:20086235 PID:200089 RGD:5490215 RGD:5490218 NCBI chr17:51,630,233...51,664,498
Ensembl chr17:51,629,964...51,666,701 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4047
    signaling pathway 1931
      cytokine and chemokine mediated signaling pathway 334
        cytokine mediated signaling pathway 333
          Interleukin mediated signaling pathway 247
            interleukin-1 family mediated signaling pathway 43
              interleukin-1 signaling pathway 43
paths to the root