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Term:interleukin-1 signaling pathway
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Accession:PW:0000883 term browser browse the term
Definition:Interleukin-1 signaling, primarily via interleukin-1beta, plays important roles in innate and adaptive immune responses. Binding of the processed cytokine to its receptor, allows for the recruitment of several accessory and adaptor proteins leading to the activation of NF-kappaB and MAPK signaling cascades. A natural receptor antagonist and a decoy receptor act as regulators of interleukin 1alpha and beta.
Synonyms:related_synonym: Il-1 signaling pathway;   PID:200089

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interleukin-1 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aim2 absent in melanoma 2 JBrowse link 1 173,349,547 173,466,040 RGD:5490211
G Casp1 caspase 1 JBrowse link 9 5,298,517 5,307,281 RGD:5490210
RGD:6484113
RGD:5490211
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 19 44,073,334 44,107,505 RGD:6484113
G Erc1 ELKS/RAB6-interacting/CAST family member 1 JBrowse link 6 119,570,796 119,848,184 RGD:6484113
G Ikbkb inhibitor of kappaB kinase beta JBrowse link 8 22,659,205 22,706,589 RGD:6484113
G Ikbkg inhibitor of kappaB kinase gamma JBrowse link X 74,393,233 74,456,792 RGD:6484113
G Il1a interleukin 1 alpha JBrowse link 2 129,299,609 129,310,186 RGD:5490209
RGD:6484113
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:5490209
RGD:6484113
G Il1r1 interleukin 1 receptor, type I JBrowse link 1 40,222,480 40,316,201 RGD:5490209
RGD:6484113
RGD:5130945
G Il1r2 interleukin 1 receptor, type II JBrowse link 1 40,084,692 40,125,230 RGD:5490209
RGD:6484113
G Il1rap interleukin 1 receptor accessory protein JBrowse link 16 26,581,509 26,730,128 RGD:5490209
G Il1rn interleukin 1 receptor antagonist JBrowse link 2 24,336,860 24,351,491 RGD:5490209
RGD:6484113
G Irak1 interleukin-1 receptor-associated kinase 1 JBrowse link X 74,013,914 74,023,921 RGD:5490215
RGD:6484113
RGD:5490218
G Irak2 interleukin-1 receptor-associated kinase 2 JBrowse link 6 113,638,467 113,695,026 RGD:5490215
G Irak3 interleukin-1 receptor-associated kinase 3 JBrowse link 10 120,141,648 120,202,130 RGD:6484113
G Irak4 interleukin-1 receptor-associated kinase 4 JBrowse link 15 94,543,613 94,568,317 RGD:5490215
RGD:6484113
RGD:5490218
G Jun jun proto-oncogene JBrowse link 4 95,049,036 95,052,222 RGD:6484113
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 11 110,399,102 110,525,522 RGD:6484113
G Map3k3 mitogen-activated protein kinase kinase kinase 3 JBrowse link 11 106,084,902 106,156,650 RGD:6484113
G Map3k7 mitogen-activated protein kinase kinase kinase 7 JBrowse link 4 31,963,492 32,023,470 RGD:5490215
RGD:6484113
RGD:5490218
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 14 33,377,898 33,447,353 RGD:6484113
G Myd88 myeloid differentiation primary response gene 88 JBrowse link 9 119,335,934 119,340,018 RGD:5490215
RGD:6484113
RGD:5490218
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 JBrowse link 3 135,584,655 135,691,969 RGD:6484113
G Nlrp1a NLR family, pyrin domain containing 1A JBrowse link 11 71,091,197 71,144,969 RGD:5490211
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 11 59,541,569 59,566,955 RGD:5490210
RGD:5490211
G Peli1 pellino 1 JBrowse link 11 21,091,283 21,150,327 RGD:5490215
G Peli2 pellino 2 JBrowse link 14 48,120,777 48,281,578 RGD:5490215
G Peli3 pellino 3 JBrowse link 19 4,929,717 4,943,127 RGD:5490215
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link 3 32,397,059 32,468,486 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 13 101,680,761 101,768,217 RGD:6484113
G Prkci protein kinase C, iota JBrowse link 3 30,995,742 31,052,740 RGD:6484113
G Prkcz protein kinase C, zeta JBrowse link 4 155,260,118 155,361,428 RGD:6484113
G Pycard PYD and CARD domain containing JBrowse link 7 127,991,373 127,993,867 RGD:5490210
RGD:5490211
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) JBrowse link 19 5,637,442 5,648,134 RGD:6484113
G Sigirr single immunoglobulin and toll-interleukin 1 receptor (TIR) domain JBrowse link 7 141,091,175 141,100,597 RGD:5490209
G Sqstm1 sequestosome 1 JBrowse link 11 50,200,152 50,210,820 RGD:6484113
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 JBrowse link 15 80,133,127 80,161,707 RGD:5490215
RGD:5490218
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 JBrowse link 10 7,905,648 7,956,255 RGD:5490215
RGD:6484113
RGD:5490218
G Tab3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 JBrowse link X 85,573,854 85,634,469 RGD:5490218
G Ticam2 toll-like receptor adaptor molecule 2 JBrowse link 18 46,558,231 46,574,533 RGD:6484113
G Tollip toll interacting protein JBrowse link 7 141,881,580 141,902,461 RGD:5490218
RGD:6484113
G Traf6 TNF receptor-associated factor 6 JBrowse link 2 101,678,420 101,701,668 RGD:5490215
RGD:6484113
RGD:5130945
RGD:5490218
G Ube2n ubiquitin-conjugating enzyme E2N JBrowse link 10 95,515,162 95,545,658 RGD:5490215
RGD:6484113
RGD:5490218
G Ube2v1 ubiquitin-conjugating enzyme E2 variant 1 JBrowse link 2 167,607,639 167,632,020 RGD:5490215
RGD:5490218

Term paths to the root
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Term Annotations click to browse term
  pathway 6011
    signaling pathway 2477
      cytokine and chemokine mediated signaling pathway 335
        cytokine mediated signaling pathway 334
          Interleukin mediated signaling pathway 248
            interleukin-1 family mediated signaling pathway 44
              interleukin-1 signaling pathway 44
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.