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Term:interleukin-1 signaling pathway
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Accession:PW:0000883 term browser browse the term
Definition:Interleukin-1 signaling, primarily via interleukin-1beta, plays important roles in innate and adaptive immune responses. Binding of the processed cytokine to its receptor, allows for the recruitment of several accessory and adaptor proteins leading to the activation of NF-kappaB and MAPK signaling cascades. A natural receptor antagonist and a decoy receptor act as regulators of interleukin 1alpha and beta.
Synonyms:related_synonym: Il-1 signaling pathway;   PID:200089

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interleukin-1 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CARD8 caspase recruitment domain family, member 8 JBrowse link 1 107,994,215 108,025,875 RGD:9068941
G CHUK component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 28 12,964,670 13,001,557 RGD:9068941
G ERC1 ELKS/RAB6-interacting/CAST family member 1 JBrowse link 27 43,004,243 43,544,260 RGD:9068941
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 23,359,551 23,419,114 RGD:9068941
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma JBrowse link X 122,232,052 122,253,499 RGD:9068941
G IL1A interleukin 1 alpha JBrowse link 17 36,969,581 36,979,445 RGD:9068941
G IL1B interleukin 1 beta JBrowse link 17 37,019,329 37,033,388 RGD:9068941
G IL1R1 interleukin 1 receptor type 1 JBrowse link 10 40,825,986 40,897,898 RGD:9068941
G IL1R2 interleukin 1 receptor type 2 JBrowse link 10 40,967,532 41,003,659 RGD:9068941
G IL1RAP interleukin 1 receptor accessory protein JBrowse link 34 22,547,422 22,628,628 RGD:9068941
G IL1RN interleukin 1 receptor antagonist JBrowse link 17 37,236,690 37,250,424 RGD:9068941
G IRAK1 interleukin 1 receptor associated kinase 1 JBrowse link X 121,853,340 121,862,582 RGD:9068941
G IRAK2 interleukin 1 receptor associated kinase 2 JBrowse link 20 8,133,987 8,197,009 RGD:9068941
G IRAK3 interleukin 1 receptor associated kinase 3 JBrowse link 10 8,683,541 8,730,757 RGD:9068941
G IRAK4 interleukin 1 receptor associated kinase 4 JBrowse link 27 10,313,782 10,340,652 RGD:9068941
G JUN Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 50,966,698 50,968,939 RGD:9068941
G MAP2K6 mitogen-activated protein kinase kinase 6 JBrowse link 9 15,840,714 15,962,400 RGD:9068941
G MAP3K3 mitogen-activated protein kinase kinase kinase 3 JBrowse link 9 11,612,527 11,678,407 RGD:9068941
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 JBrowse link 12 49,669,849 49,740,039 RGD:9068941
G MAPK8 mitogen-activated protein kinase 8 JBrowse link 28 323,361 410,367 RGD:9068941
G MYD88 MYD88 innate immune signal transduction adaptor JBrowse link 23 7,901,578 7,905,274 RGD:9068941
G NFKB1 nuclear factor kappa B subunit 1 JBrowse link 32 23,948,598 24,040,704 RGD:9068941
G NLRP1 NLR family pyrin domain containing 1 JBrowse link 5 31,264,554 31,299,538 RGD:9068941
G NLRP3 NLR family pyrin domain containing 3 JBrowse link 8 251,776 313,290 RGD:9068941
G PELI1 pellino E3 ubiquitin protein ligase 1 JBrowse link 10 63,727,905 63,863,599 RGD:9068941
G PELI2 pellino E3 ubiquitin protein ligase family member 2 JBrowse link 8 31,834,287 32,013,387 RGD:9068941
G PELI3 pellino E3 ubiquitin protein ligase family member 3 JBrowse link 18 50,870,483 50,881,089 RGD:9068941
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link 34 12,600,140 12,681,905 RGD:9068941
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 53,447,802 53,527,563 RGD:9068941
G PRKCI protein kinase C iota JBrowse link 34 34,767,066 34,839,823 RGD:9068941
G PRKCZ protein kinase C zeta JBrowse link 5 57,012,020 57,113,346 RGD:9068941
G PYCARD PYD and CARD domain containing JBrowse link 6 17,049,352 17,051,348 RGD:9068941
G RELA RELA proto-oncogene, NF-kB subunit JBrowse link 18 51,550,003 51,558,861 RGD:9068941
G SIGIRR single Ig and TIR domain containing JBrowse link 18 25,548,484 25,553,720 RGD:9068941
G SQSTM1 sequestosome 1 JBrowse link 11 1,859,776 1,869,289 RGD:9068941
G TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 JBrowse link 10 25,623,381 25,657,630 RGD:9068941
G TAB2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 JBrowse link 1 40,125,842 40,216,455 RGD:9068941
G TAB3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 JBrowse link X 25,950,071 26,039,180 RGD:9068941
G TICAM2 toll like receptor adaptor molecule 2 JBrowse link 11 5,312,383 5,313,099 RGD:9068941
G TMED7 transmembrane p24 trafficking protein 7 JBrowse link 11 5,342,265 5,356,828 RGD:9068941
G TOLLIP toll interacting protein JBrowse link 18 45,559,385 45,578,467 RGD:9068941
G TRAF6 TNF receptor associated factor 6 JBrowse link 18 31,674,242 31,689,160 RGD:9068941
G UBE2N ubiquitin conjugating enzyme E2 N JBrowse link 15 33,651,478 33,687,049 RGD:9068941
G UBE2V1 ubiquitin conjugating enzyme E2 V1 JBrowse link 24 36,570,172 36,601,200 RGD:9068941

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  pathway 5644
    signaling pathway 2414
      cytokine and chemokine mediated signaling pathway 335
        cytokine mediated signaling pathway 334
          Interleukin mediated signaling pathway 248
            interleukin-1 family mediated signaling pathway 44
              interleukin-1 signaling pathway 44
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.