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Term:interleukin-1 signaling pathway
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Accession:PW:0000883 term browser browse the term
Definition:Interleukin-1 signaling, primarily via interleukin-1beta, plays important roles in innate and adaptive immune responses. Binding of the processed cytokine to its receptor, allows for the recruitment of several accessory and adaptor proteins leading to the activation of NF-kappaB and MAPK signaling cascades. A natural receptor antagonist and a decoy receptor act as regulators of interleukin 1alpha and beta.
Synonyms:related_synonym: Il-1 signaling pathway;   PID:200089

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interleukin-1 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chuk component of inhibitor of nuclear factor kappa B kinase complex JBrowse link NW_004955507 6,066,026 6,102,066 RGD:9068941
G Erc1 ELKS/RAB6-interacting/CAST family member 1 JBrowse link NW_004955454 3,584,910 4,036,276 RGD:9068941
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link NW_004955536 611,965 658,647 RGD:9068941
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma JBrowse link NW_004955580 1,053,823 1,069,802 RGD:9068941
G Il1a interleukin 1 alpha JBrowse link NW_004955470 1,527,710 1,538,418 RGD:9068941
G Il1b interleukin 1 beta JBrowse link NW_004955470 1,486,936 1,491,888 RGD:9068941
G Il1r1 interleukin 1 receptor type 1 JBrowse link NW_004955470 7,685,498 7,703,374 RGD:9068941
G Il1r2 interleukin 1 receptor type 2 JBrowse link NW_004955470 7,518,565 7,562,219 RGD:9068941
G Il1rap interleukin 1 receptor accessory protein JBrowse link NW_004955420 17,463,493 17,591,054 RGD:9068941
G Il1rn interleukin 1 receptor antagonist JBrowse link NW_004955470 1,145,022 1,159,413 RGD:9068941
G Irak1 interleukin 1 receptor associated kinase 1 JBrowse link NW_004955580 663,651 668,622 RGD:9068941
G Irak2 interleukin 1 receptor associated kinase 2 JBrowse link NW_004955561 1,585,842 1,650,268 RGD:9068941
G Irak3 interleukin 1 receptor associated kinase 3 JBrowse link NW_004955458 12,839,995 12,880,285 RGD:9068941
G Irak4 interleukin 1 receptor associated kinase 4 JBrowse link NW_004955500 3,010,505 3,039,090 RGD:9068941
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link NW_004955464 1,107,598 1,110,326 RGD:9068941
G LOC102006100 TIR domain-containing adapter molecule 2 JBrowse link NW_004955408 35,342,733 35,382,821 RGD:9068941
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link NW_004955478 3,331,607 3,448,840 RGD:9068941
G Map3k3 mitogen-activated protein kinase kinase kinase 3 JBrowse link NW_004955478 8,122,999 8,185,138 RGD:9068941
G Map3k7 mitogen-activated protein kinase kinase kinase 7 JBrowse link NW_004955411 17,177,335 17,229,957 RGD:9068941
G Mapk8 mitogen-activated protein kinase 8 JBrowse link NW_004955556 1,593,552 1,705,543 RGD:9068941
G Myd88 MYD88 innate immune signal transduction adaptor JBrowse link NW_004955427 25,553,589 25,557,654 RGD:9068941
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link NW_004955496 5,842,734 5,950,995 RGD:9068941
G Nlrp3 NLR family pyrin domain containing 3 JBrowse link NW_004955581 597,952 616,903 RGD:9068941
G Peli1 pellino E3 ubiquitin protein ligase 1 JBrowse link NW_004955424 20,212,077 20,263,761 RGD:9068941
G Peli2 pellino E3 ubiquitin protein ligase family member 2 JBrowse link NW_004955466 10,228,101 10,335,129 RGD:9068941
G Peli3 pellino E3 ubiquitin protein ligase family member 3 JBrowse link NW_004955422 18,868,696 18,877,826 RGD:9068941
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link NW_004955420 8,355,415 8,427,024 RGD:9068941
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link NW_004955446 1,020,707 1,098,327 RGD:9068941
G Prkci protein kinase C iota JBrowse link NW_004955420 423,406 486,676 RGD:9068941
G Prkcz protein kinase C zeta JBrowse link NW_004955486 8,947,579 9,021,702 RGD:9068941
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link NW_004955422 19,602,930 19,612,263 RGD:9068941
G Sigirr single Ig and TIR domain containing JBrowse link NW_004955476 11,603,375 11,610,606 RGD:9068941
G Sqstm1 sequestosome 1 JBrowse link NW_004955408 757,426 764,989 RGD:9068941
G Tab1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 JBrowse link NW_004955413 25,290,733 25,315,267 RGD:9068941
G Tab2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 JBrowse link NW_004955439 11,826,469 11,903,103 RGD:9068941
G Tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 JBrowse link NW_004955535 3,547,556 3,612,705 RGD:9068941
G Ticam2 toll like receptor adaptor molecule 2 JBrowse link NW_004955411 31,010,373 31,042,321 RGD:9068941
G Tollip toll interacting protein JBrowse link NW_004955476 10,987,223 11,009,134 RGD:9068941
G Traf6 TNF receptor associated factor 6 JBrowse link NW_004955422 9,925,765 9,950,354 RGD:9068941
G Ube2n ubiquitin conjugating enzyme E2 N JBrowse link NW_004955405 30,240,402 30,278,362 RGD:9068941
G Ube2v1 ubiquitin conjugating enzyme E2 V1 JBrowse link NW_004955445 8,142,882 8,174,199 RGD:9068941

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  pathway 5436
    signaling pathway 2372
      cytokine and chemokine mediated signaling pathway 318
        cytokine mediated signaling pathway 317
          Interleukin mediated signaling pathway 234
            interleukin-1 family mediated signaling pathway 41
              interleukin-1 signaling pathway 41
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.