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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family
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Accession:PW:0000855 term browser browse the term
Definition:Acetylcholine signaling via receptor type M1, M3 and M5 primarily engages G alphaq protein family resulting in activation of phospholipase C and mobilization of intracellular calcium. The receptors are expressed in various areas of the brain and the cell membrane of effector tissues.


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acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHRM1 cholinergic receptor muscarinic 1 ISO RGD PMID:23841840 RGD:8549585 NCBI chr 2:8,858,765...8,872,042 JBrowse link
G CHRM3 cholinergic receptor muscarinic 3 ISO RGD PMID:23841840 RGD:8549585 NCBI chr14:51,818,625...52,363,662
Ensembl chr14:51,828,231...51,830,003 		JBrowse link
G CHRM5 cholinergic receptor muscarinic 5 ISO RGD PMID:23841840 RGD:8549585 NCBI chr 7:80,423,768...80,429,187
Ensembl chr 7:80,427,360...80,428,963 		JBrowse link
G GNA11 G protein subunit alpha 11 ISO RGD PMID:23759942 RGD:8549590 NCBI chr 2:75,439,405...75,456,855
Ensembl chr 2:75,437,201...75,457,092 		JBrowse link
G GNA14 G protein subunit alpha 14 ISO RGD PMID:23759942 RGD:8549590 NCBI chr 1:230,341,947...230,545,123
Ensembl chr 1:230,341,942...230,546,120 		JBrowse link
G GNAQ G protein subunit alpha q ISO RGD PMID:23759942 RGD:8549590 NCBI chr 1:230,607,469...230,906,988
Ensembl chr 1:230,605,265...230,907,674 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4041
    signaling pathway 1918
      chemical compound signaling pathway 85
        acetylcholine signaling pathway 39
          acetylcholine signaling pathway via muscarinic acetylcholine receptor 19
            acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family 6
Path 2
Term Annotations click to browse term
  pathway 4041
    signaling pathway 1918
      signaling pathway pertinent to the brain and nervous system 230
        neuron-to-neuron signaling pathways 130
          neuron-to-neuron signaling pathway via the chemical synapse 128
            acetylcholine signaling pathway 39
              acetylcholine signaling pathway via muscarinic acetylcholine receptor 19
                acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family 6
paths to the root