Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:gemcitabine pharmacokinetics pathway
go back to main search page
Accession:PW:0000759 term browser browse the term
Definition:The pathway of processing - absorption, distribution, metabolism or elimination of gemcitabine. Gemcitabine is a cytidine analogue administered as a prodrug for the treatment of certain cancers. The diphosphate form is an inhibitor of ribonucleotide reductases, essential enzymes of deoxyribonucleotide synthesis. Genetic variations can result in changes in the availability of the drug.
Synonyms:related_synonym: SMP:00603



show annotations for term's descendants           Sort by:
gemcitabine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmpk1 cytidine/uridine monophosphate kinase 1 ISO SMPDB SMP:00603 NCBI chr 5:133,717,073...133,744,623
Ensembl chr 5:128,480,301...128,507,830
JBrowse link
G Ctps1 CTP synthase 1 ISO SMPDB SMP:00603 NCBI chr 5:139,372,349...139,440,441
Ensembl chr 5:134,125,025...134,154,180
JBrowse link
G Dck deoxycytidine kinase ISO SMPDB SMP:00603 NCBI chr14:19,589,298...19,610,326
Ensembl chr14:19,305,218...19,326,247
JBrowse link
G Dctd dCMP deaminase ISO SMPDB SMP:00603 NCBI chr16:50,799,699...50,831,398
Ensembl chr16:44,055,128...44,098,446
JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 ISO SMPDB SMP:00603 NCBI chr10:79,403,939...79,426,620
Ensembl chr10:78,906,083...78,916,408
JBrowse link
G Nt5c 5', 3'-nucleotidase, cytosolic ISO SMPDB SMP:00603 NCBI chr10:100,739,591...100,742,276
Ensembl chr10:100,739,588...100,741,954
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 ISO SMPDB SMP:00603 NCBI chr 1:166,235,904...166,260,206
Ensembl chr 1:156,823,960...156,848,261
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 ISO SMPDB SMP:00603 NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:41,340,557...41,346,773
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B ISO SMPDB SMP:00603 NCBI chr 7:70,962,008...70,993,726
Ensembl chr 7:69,078,291...69,108,633
JBrowse link
G Slc28a1 solute carrier family 28 member 1 ISO SMPDB SMP:00603 NCBI chr 1:135,079,375...135,122,791
Ensembl chr 1:135,081,385...135,122,464
JBrowse link
G Slc28a3 solute carrier family 28 member 3 ISO SMPDB SMP:00603 NCBI chr17:6,068,034...6,120,421
Ensembl chr17:6,062,549...6,114,038
JBrowse link
G Slc29a1 solute carrier family 29 member 1 ISO SMPDB SMP:00603 NCBI chr 9:22,897,099...22,911,640
Ensembl chr 9:15,399,612...15,414,203
JBrowse link
G Tyms thymidylate synthetase ISO SMPDB SMP:00603 NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    drug pathway 397
      antineoplastic and immunomodulatory drug pathway 156
        antineoplastic drug pathway 154
          gemcitabine pathway 13
            gemcitabine pharmacokinetics pathway 13
paths to the root