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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:warfarin pharmacodynamics pathway
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Accession:PW:0000731 term browser browse the term
Definition:The pathway of warfarin-target interaction and of the biochemical or physiological responses to drug. Warfarin is used as anticoagulant that antagonizes the vitamin K dependent clotting pathway. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00268
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warfarin pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COL1A1 collagen type I alpha 1 chain ISO SMPDB SMP:00268 NCBI chr 9:26,183,852...26,199,927
Ensembl chr 9:26,183,852...26,199,927 		JBrowse link
G F10 coagulation factor X ISO SMPDB SMP:00268 NCBI chr22:60,585,563...60,597,027
Ensembl chr22:60,571,822...60,597,024 		JBrowse link
G F11 coagulation factor XI ISO SMPDB SMP:00268 NCBI chr16:44,469,609...44,492,833
Ensembl chr16:44,469,632...44,540,292 		JBrowse link
G F12 coagulation factor XII ISO SMPDB SMP:00268 NCBI chr 4:35,950,642...35,968,137
Ensembl chr 4:35,950,695...35,998,025 		JBrowse link
G F13A1 coagulation factor XIII A chain ISO SMPDB SMP:00268 NCBI chr35:6,186,750...6,347,522
Ensembl chr35:6,187,235...6,349,773 		JBrowse link
G F13B coagulation factor XIII B chain ISO SMPDB SMP:00268 NCBI chr 7:5,674,458...5,700,928
Ensembl chr 7:5,674,416...5,700,905 		JBrowse link
G F2 coagulation factor II, thrombin ISO SMPDB SMP:00268 NCBI chr18:42,782,744...42,799,531
Ensembl chr18:42,782,751...42,799,459 		JBrowse link
G F3 coagulation factor III, tissue factor ISO SMPDB SMP:00268 NCBI chr 6:54,709,581...54,720,603
Ensembl chr 6:54,708,471...54,720,607 		JBrowse link
G F5 coagulation factor V ISO SMPDB SMP:00268 NCBI chr 7:28,999,481...29,069,603
Ensembl chr 7:28,999,512...29,069,296 		JBrowse link
G F7 coagulation factor VII ISO SMPDB SMP:00268 NCBI chr22:60,572,459...60,582,743
Ensembl chr22:60,571,822...60,597,024 		JBrowse link
G F8 coagulation factor VIII ISO SMPDB SMP:00268 NCBI chr  X:122,894,974...123,046,343
Ensembl chr  X:122,885,162...123,043,414 		JBrowse link
G F9 coagulation factor IX ISO SMPDB SMP:00268 NCBI chr  X:109,501,341...109,533,798
Ensembl chr  X:109,501,341...109,533,798 		JBrowse link
G FGA fibrinogen alpha chain ISO SMPDB SMP:00268 NCBI chr15:52,238,305...52,247,017
Ensembl chr15:52,236,198...52,246,975 		JBrowse link
G FGB fibrinogen beta chain ISO SMPDB SMP:00268 NCBI chr15:52,220,690...52,228,526
Ensembl chr15:52,220,611...52,228,250 		JBrowse link
G FGG fibrinogen gamma chain ISO SMPDB SMP:00268 NCBI chr15:52,261,215...52,270,077
Ensembl chr15:52,261,217...52,269,964 		JBrowse link
G GGCX gamma-glutamyl carboxylase ISO SMPDB SMP:00268 NCBI chr17:39,512,293...39,525,251
Ensembl chr17:39,512,387...39,529,121 		JBrowse link
G KLKB1 kallikrein B1 ISO SMPDB SMP:00268 NCBI chr16:44,492,735...44,517,854
Ensembl chr16:44,469,632...44,540,292 		JBrowse link
G PLAT plasminogen activator, tissue type ISO SMPDB SMP:00268 NCBI chr16:23,469,590...23,496,013 JBrowse link
G PLG plasminogen ISO SMPDB SMP:00268 NCBI chr 1:49,497,229...49,535,260
Ensembl chr 1:49,497,229...49,535,260 		JBrowse link
G VKORC1 vitamin K epoxide reductase complex subunit 1 ISO SMPDB
RGD		 PMID:26287237 RGD:11354881 SMP:00268 NCBI chr 6:17,140,565...17,142,621
Ensembl chr 6:17,140,633...17,142,547 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4052
    drug pathway 379
      blood and blood forming organs drug pathway 57
        antithrombotic drug pathway 57
          anticoagulant drug pathway 26
            vitamin K antagonist drug pathway 25
              warfarin drug pathway 25
                warfarin pharmacodynamics pathway 20
paths to the root