Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:insulin secretion pathway
go back to main search page
Accession:PW:0000674 term browser browse the term
Definition:Insulin secretion by pancreatic beta-cells is an important aspect of glucose homeostasis. A major component of glucose-stimulated insulin secretion is represented by the route dependent on the ATP-sensitive potassium channels. However, other contributions are also likely to promote insulin secretion.
Synonyms:related_synonym: Regulation of insulin secretion;   insulin secretion

View Interactive Diagram



show annotations for term's descendants           Sort by:
insulin secretion pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP-binding cassette, sub-family C member 8 TAS RGD PMID:18940941 RGD:2311063 NCBI chr 7:45,753,952...45,829,441
Ensembl chr 7:45,753,947...45,829,457
JBrowse link
G Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit TAS RGD PMID:16868246 RGD:2311105 NCBI chr 8:85,065,257...85,366,880
Ensembl chr 8:85,065,268...85,366,875
JBrowse link
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit TAS RGD PMID:16868246 RGD:2311105 NCBI chr 6:118,564,201...119,174,345
Ensembl chr 6:118,564,201...119,173,851
JBrowse link
G Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit TAS RGD PMID:16868246 RGD:2311105 NCBI chr14:29,761,898...30,213,113
Ensembl chr14:29,761,896...30,213,412
JBrowse link
G Cdc42 cell division cycle 42 TAS RGD PMID:19295123 RGD:2311087 NCBI chr 4:137,047,011...137,085,007
Ensembl chr 4:137,047,007...137,085,031
JBrowse link
G Gck glucokinase TAS RGD PMID:18774732 RGD:2311061 NCBI chr11:5,850,816...5,900,081
Ensembl chr11:5,850,820...5,900,081
JBrowse link
G Kcnb1 potassium voltage gated channel, Shab-related subfamily, member 1 TAS RGD PMID:12830383 RGD:2311121 NCBI chr 2:166,937,889...167,032,088
Ensembl chr 2:166,937,889...167,032,075
JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 TAS RGD PMID:18940941 RGD:2311063 NCBI chr 7:45,746,545...45,750,215
Ensembl chr 7:45,743,377...45,750,188
JBrowse link
G Rab27a RAB27A, member RAS oncogene family TAS RGD PMID:19295123 RGD:2311087 NCBI chr 9:72,952,092...73,004,905
Ensembl chr 9:72,952,136...73,004,911
JBrowse link
G Rab3a RAB3A, member RAS oncogene family TAS RGD PMID:19295123 RGD:2311087 NCBI chr 8:71,207,258...71,211,276
Ensembl chr 8:71,207,328...71,211,323
JBrowse link
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 TAS RGD PMID:18774732 RGD:2311061 NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508
JBrowse link
G Snap25 synaptosomal-associated protein 25 ISO RGD PMID:12830383 RGD:2311121 NCBI chr 2:136,555,359...136,624,348
Ensembl chr 2:136,555,373...136,624,348
JBrowse link
G Stx1a syntaxin 1A (brain) TAS RGD PMID:19295123 RGD:2311087 NCBI chr 5:135,051,473...135,079,954
Ensembl chr 5:135,052,336...135,079,954
JBrowse link
G Stxbp1 syntaxin binding protein 1 TAS RGD PMID:19295123 RGD:2311087 NCBI chr 2:32,677,619...32,737,249
Ensembl chr 2:32,677,614...32,737,257
JBrowse link
G Syt7 synaptotagmin VII ISO RGD PMID:18713958 PMID:17709608 RGD:2311148, RGD:2311143 NCBI chr19:10,366,142...10,430,545
Ensembl chr19:10,366,454...10,430,544
JBrowse link
G Syt9 synaptotagmin IX ISO RGD PMID:18713958 PMID:16165130 RGD:2311148, RGD:2311147 NCBI chr 7:106,969,929...107,147,863
Ensembl chr 7:106,969,935...107,147,863
JBrowse link
G Unc13a unc-13 homolog A TAS RGD PMID:19295123 RGD:2311087 NCBI chr 8:72,079,356...72,124,418
Ensembl chr 8:72,077,061...72,124,401
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 TAS RGD PMID:19295123 RGD:2311087 NCBI chr11:68,979,354...68,983,207
Ensembl chr11:68,979,316...68,983,210
JBrowse link
altered insulin secretion pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP-binding cassette, sub-family C member 8 ISO DNA:missense mutation::A1369S (human) RGD PMID:17259403 RGD:2313628 NCBI chr 7:45,753,952...45,829,441
Ensembl chr 7:45,753,947...45,829,457
JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 ISO polymorphisms in the human gene are linked to altered insulin secretion; E23K polymorphism appears to confer susceptibility to diabetes type-2 in Caucasian population
DNA:missense mutation::p.E23K (human)
RGD PMID:15565284 PMID:17259403 RGD:2313610, RGD:2313628 NCBI chr 7:45,746,545...45,750,215
Ensembl chr 7:45,743,377...45,750,188
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6074
    regulatory pathway 3686
      homeostasis pathway 1721
        glucose homeostasis pathway 345
          insulin secretion pathway 18
            altered insulin secretion pathway 2
paths to the root