PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: insulin secretion pathway
Accession: PW:0000674
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Definition: Insulin secretion by pancreatic beta-cells is an important aspect of glucose homeostasis. A major component of glucose-stimulated insulin secretion is represented by the route dependent on the ATP-sensitive potassium channels. However, other contributions are also likely to promote insulin secretion.
Synonyms: related_synonym: Regulation of insulin secretion; insulin secretion
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Abcc8
ATP-binding cassette, sub-family C member 8
TAS
RGD
PMID:18940941
RGD:2311063
NCBI chr 7:45,753,952...45,829,441
Ensembl chr 7:45,753,947...45,829,457
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Cacna1a
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
TAS
RGD
PMID:16868246
RGD:2311105
NCBI chr 8:85,065,257...85,366,880
Ensembl chr 8:85,065,268...85,366,875
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Cacna1c
calcium channel, voltage-dependent, L type, alpha 1C subunit
TAS
RGD
PMID:16868246
RGD:2311105
NCBI chr 6:118,564,201...119,174,345
Ensembl chr 6:118,564,201...119,173,851
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Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
TAS
RGD
PMID:16868246
RGD:2311105
NCBI chr14:29,761,898...30,213,113
Ensembl chr14:29,761,896...30,213,412
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Cdc42
cell division cycle 42
TAS
RGD
PMID:19295123
RGD:2311087
NCBI chr 4:137,047,011...137,085,007
Ensembl chr 4:137,047,007...137,085,031
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Gck
glucokinase
TAS
RGD
PMID:18774732
RGD:2311061
NCBI chr11:5,850,816...5,900,081
Ensembl chr11:5,850,820...5,900,081
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Kcnb1
potassium voltage gated channel, Shab-related subfamily, member 1
TAS
RGD
PMID:12830383
RGD:2311121
NCBI chr 2:166,937,889...167,032,088
Ensembl chr 2:166,937,889...167,032,075
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Kcnj11
potassium inwardly rectifying channel, subfamily J, member 11
TAS
RGD
PMID:18940941
RGD:2311063
NCBI chr 7:45,746,545...45,750,215
Ensembl chr 7:45,743,377...45,750,188
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Rab27a
RAB27A, member RAS oncogene family
TAS
RGD
PMID:19295123
RGD:2311087
NCBI chr 9:72,952,092...73,004,905
Ensembl chr 9:72,952,136...73,004,911
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Rab3a
RAB3A, member RAS oncogene family
TAS
RGD
PMID:19295123
RGD:2311087
NCBI chr 8:71,207,258...71,211,276
Ensembl chr 8:71,207,328...71,211,323
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Slc2a2
solute carrier family 2 (facilitated glucose transporter), member 2
TAS
RGD
PMID:18774732
RGD:2311061
NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508
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Snap25
synaptosomal-associated protein 25
ISO
RGD
PMID:12830383
RGD:2311121
NCBI chr 2:136,555,359...136,624,348
Ensembl chr 2:136,555,373...136,624,348
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Stx1a
syntaxin 1A (brain)
TAS
RGD
PMID:19295123
RGD:2311087
NCBI chr 5:135,051,473...135,079,954
Ensembl chr 5:135,052,336...135,079,954
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Stxbp1
syntaxin binding protein 1
TAS
RGD
PMID:19295123
RGD:2311087
NCBI chr 2:32,677,619...32,737,249
Ensembl chr 2:32,677,614...32,737,257
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Syt7
synaptotagmin VII
ISO
RGD
PMID:18713958 PMID:17709608
RGD:2311148 , RGD:2311143
NCBI chr19:10,366,142...10,430,545
Ensembl chr19:10,366,454...10,430,544
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Syt9
synaptotagmin IX
ISO
RGD
PMID:18713958 PMID:16165130
RGD:2311148 , RGD:2311147
NCBI chr 7:106,969,929...107,147,863
Ensembl chr 7:106,969,935...107,147,863
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Unc13a
unc-13 homolog A
TAS
RGD
PMID:19295123
RGD:2311087
NCBI chr 8:72,079,356...72,124,418
Ensembl chr 8:72,077,061...72,124,401
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Vamp2
vesicle-associated membrane protein 2
TAS
RGD
PMID:19295123
RGD:2311087
NCBI chr11:68,979,354...68,983,207
Ensembl chr11:68,979,316...68,983,210
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Abcc8
ATP-binding cassette, sub-family C member 8
ISO
DNA:missense mutation::A1369S (human)
RGD
PMID:17259403
RGD:2313628
NCBI chr 7:45,753,952...45,829,441
Ensembl chr 7:45,753,947...45,829,457
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Kcnj11
potassium inwardly rectifying channel, subfamily J, member 11
ISO
polymorphisms in the human gene are linked to altered insulin secretion; E23K polymorphism appears to confer susceptibility to diabetes type-2 in Caucasian population DNA:missense mutation::p.E23K (human)
RGD
PMID:15565284 PMID:17259403
RGD:2313610 , RGD:2313628
NCBI chr 7:45,746,545...45,750,215
Ensembl chr 7:45,743,377...45,750,188
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