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The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (

Term:glypican signaling pathway
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Accession:PW:0000658 term browser browse the term
Definition:Glypicans are heparan sulfate proteoglycans represented by six families in mammals. They impact on a number of signaling pathways; the effect on signaling can be either inhibitory or stimulatory, depending on the context. They also appear to integrate directional cues important for neuronal migration, axon guidance and synapse formation.
Synonyms:related_synonym: PID:200026;   PID:200126;   PID:200225

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glypican signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO PID PID:200026 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase ISO PID PID:200026 NCBI chr15:46,555,552...46,593,778
Ensembl chr15:46,555,188...46,593,653
JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO PID PID:200225 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Fgf2 fibroblast growth factor 2 ISO PID PID:200026 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgf7 fibroblast growth factor 7 ISO PID PID:200225 NCBI chr 3:118,315,859...118,368,464
Ensembl chr 3:118,317,761...118,366,872
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 ISO PID PID:200026 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase ISO PID PID:200026 NCBI chr 5:151,172,189...151,199,746
Ensembl chr 5:151,172,206...151,199,745
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 ISO PID PID:200026 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) ISO PID PID:200225 NCBI chr 1:142,185,092...142,198,167
Ensembl chr 1:142,185,094...142,197,182
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase ISO PID PID:200026 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G Gpc1 glypican 1 ISO PID PID:200026 NCBI chr 9:99,998,275...100,026,818
Ensembl chr 9:99,998,275...100,026,818
JBrowse link
G Gpc2 glypican 2 ISO PID PID:200126 NCBI chr12:19,593,041...19,599,374
Ensembl chr12:19,593,041...19,599,374
JBrowse link
G Gpc3 glypican 3 ISO PID PID:200225 NCBI chr  X:139,579,268...139,947,093
Ensembl chr  X:139,579,268...139,916,883
JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase ISO PID PID:200026 NCBI chr 3:148,579,917...148,623,026
Ensembl chr 3:148,579,920...148,623,033
JBrowse link
G Lama1 laminin subunit alpha 1 ISO PID PID:200026 NCBI chr 9:115,916,907...116,042,123
Ensembl chr 9:115,916,907...116,042,123
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase ISO PID PID:200026 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase ISO PID PID:200026 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO PID PID:200225 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO PID PID:200225 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mdk midkine ISO PID PID:200126 NCBI chr 3:80,841,003...80,843,895
Ensembl chr 3:80,841,005...80,842,916
JBrowse link
G Nrg1 neuregulin 1 ISO PID PID:200026 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Pla2g2a phospholipase A2 group IIA ISO PID PID:200026 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
G Prnp prion protein ISO PID PID:200026 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Ptch1 patched 1 ISO PID PID:200225 NCBI chr17:1,032,242...1,085,885
Ensembl chr17:1,029,048...1,093,873
JBrowse link
G Serpinc1 serpin family C member 1 ISO PID PID:200026 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link
G Shh sonic hedgehog signaling molecule ISO PID PID:200225 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Slit2 slit guidance ligand 2 ISO PID PID:200026 NCBI chr14:66,831,848...67,171,491
Ensembl chr14:66,831,848...67,170,361
JBrowse link
G Smad2 SMAD family member 2 ISO PID PID:200026 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO PID PID:200026 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Tdgf1 teratocarcinoma-derived growth factor 1 ISO PID PID:200026 NCBI chr 8:119,215,266...119,220,909
Ensembl chr 8:119,215,495...119,219,232
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO PID PID:200026 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 ISO PID PID:200026 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tgfb3 transforming growth factor, beta 3 ISO PID PID:200026 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 ISO PID PID:200026 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 ISO PID PID:200026 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Vegfa vascular endothelial growth factor A ISO PID PID:200026 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase ISO PID PID:200026 NCBI chr 9:121,802,471...121,918,906
Ensembl chr 9:121,802,673...121,902,678
JBrowse link

Term paths to the root
Path 1
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  pathway 6106
    signaling pathway 2647
      glycoconjugated protein signaling pathway 415
        proteoglycan signaling pathway 136
          glypican signaling pathway 37
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