Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:Endoplasmic Reticulum-associated degradation pathway
go back to main search page
Accession:PW:0000638 term browser browse the term
Definition:In the endoplasmic reticulum correctly folded proteins are targeted for further export whereas misfolded proteins are retained and targeted for degradation.
Synonyms:related_synonym: ERAD pathway;   KEGG:04141


show annotations for term's descendants       view all columns           Sort by:
 
Endoplasmic Reticulum-associated degradation pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AMFR autocrine motility factor receptor JBrowse link 16 56,361,452 56,425,545 RGD:6907045
G ATF4 activating transcription factor 4 JBrowse link 22 39,514,494 39,522,686 RGD:6907045
G ATF6 activating transcription factor 6 JBrowse link 1 161,766,320 161,964,070 RGD:6907045
G ATF6B activating transcription factor 6 beta JBrowse link 6 32,115,264 32,128,246 RGD:6907045
G ATXN3 ataxin 3 JBrowse link 14 92,058,552 92,106,621 RGD:6907045
G ATXN3L ataxin 3 like JBrowse link X 13,318,647 13,320,399 RGD:6907045
G BAG1 BAG cochaperone 1 JBrowse link 9 33,252,471 33,264,708 RGD:6907045
G BAG2 BAG cochaperone 2 JBrowse link 6 57,172,326 57,189,833 RGD:6907045
G BAK1 BCL2 antagonist/killer 1 JBrowse link 6 33,572,552 33,580,296 RGD:6907045
G BAX BCL2 associated X, apoptosis regulator JBrowse link 19 48,954,825 48,961,798 RGD:6907045
G BCAP31 B cell receptor associated protein 31 JBrowse link X 153,700,492 153,724,746 RGD:6907045
G BCL2 BCL2 apoptosis regulator JBrowse link 18 63,123,346 63,320,280 RGD:6907045
G CALR calreticulin JBrowse link 19 12,938,609 12,944,489 RGD:6907045
G CANX calnexin JBrowse link 5 179,678,646 179,731,641 RGD:6907045
G CAPN1 calpain 1 JBrowse link 11 65,181,373 65,212,006 RGD:6907045
G CAPN2 calpain 2 JBrowse link 1 223,701,593 223,776,018 RGD:6907045
G CKAP4 cytoskeleton associated protein 4 JBrowse link 12 106,237,881 106,248,020 RGD:6907045
G CRYAA crystallin alpha A JBrowse link 21 43,169,008 43,172,810 RGD:6907045
G CRYAB crystallin alpha B JBrowse link 11 111,908,564 111,923,740 RGD:6907045
G CUL1 cullin 1 JBrowse link 7 148,697,756 148,801,110 RGD:6907045
G DAD1 defender against cell death 1 JBrowse link 14 22,564,907 22,589,224 RGD:6907045
G DDIT3 DNA damage inducible transcript 3 JBrowse link 12 57,516,588 57,520,517 RGD:6907045
G DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit JBrowse link 1 20,651,777 20,661,369 RGD:6907045
G DERL1 derlin 1 JBrowse link 8 123,013,164 123,042,423 RGD:6907045
G DERL2 derlin 2 JBrowse link 17 5,471,254 5,486,225 RGD:6907045
G DERL3 derlin 3 JBrowse link 22 23,834,498 23,839,348 RGD:6907045
G DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 JBrowse link 9 33,025,203 33,039,907 RGD:6907045
G DNAJA2 DnaJ heat shock protein family (Hsp40) member A2 JBrowse link 16 46,955,362 46,973,674 RGD:6907045
G DNAJB1 DnaJ heat shock protein family (Hsp40) member B1 JBrowse link 19 14,514,764 14,530,597 RGD:6907045
G DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 JBrowse link 3 186,570,720 186,585,793 RGD:6907045
G DNAJB12 DnaJ heat shock protein family (Hsp40) member B12 JBrowse link 10 72,332,835 72,354,919 RGD:6907045
G DNAJB2 DnaJ heat shock protein family (Hsp40) member B2 JBrowse link 2 219,279,366 219,286,895 RGD:6907045
G DNAJC1 DnaJ heat shock protein family (Hsp40) member C1 JBrowse link 10 21,756,548 22,003,763 RGD:6907045
G DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 JBrowse link 2 182,716,257 182,794,464 RGD:6907045
G DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 JBrowse link 13 95,677,139 95,794,988 RGD:6907045
G DNAJC5 DnaJ heat shock protein family (Hsp40) member C5 JBrowse link 20 63,895,126 63,936,026 RGD:6907045
G DNAJC5B DnaJ heat shock protein family (Hsp40) member C5 beta JBrowse link 8 66,014,978 66,101,245 RGD:6907045
G DNAJC5G DnaJ heat shock protein family (Hsp40) member C5 gamma JBrowse link 2 27,275,427 27,281,499 RGD:6907045
G EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link 3 5,187,707 5,219,963 RGD:6907045
G EDEM2 ER degradation enhancing alpha-mannosidase like protein 2 JBrowse link 20 35,115,364 35,147,336 RGD:6907045
G EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 JBrowse link 1 184,690,237 184,754,907 RGD:6907045
G EIF2AK1 eukaryotic translation initiation factor 2 alpha kinase 1 JBrowse link 7 6,022,247 6,059,229 RGD:6907045
G EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 JBrowse link 2 37,099,210 37,157,065 RGD:6907045
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 2 88,556,740 88,627,464 RGD:6907045
G EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 JBrowse link 15 39,934,115 40,035,591 RGD:6907045
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha JBrowse link 14 67,360,328 67,386,516 RGD:6907045
G ERLEC1 endoplasmic reticulum lectin 1 JBrowse link 2 53,786,931 53,834,524 RGD:6907045
G ERN1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 17 64,039,142 64,132,469 RGD:6907045
G ERO1A endoplasmic reticulum oxidoreductase 1 alpha JBrowse link 14 52,639,915 52,695,750 RGD:6907045
G ERO1B endoplasmic reticulum oxidoreductase 1 beta JBrowse link 1 236,213,064 236,281,983 RGD:6907045
G ERP29 endoplasmic reticulum protein 29 JBrowse link 12 112,013,340 112,023,449 RGD:6907045
G FBXO2 F-box protein 2 JBrowse link 1 11,648,387 11,654,429 RGD:6907045
G FBXO6 F-box protein 6 JBrowse link 1 11,664,200 11,674,354 RGD:6907045
G GANAB glucosidase II alpha subunit JBrowse link 11 62,624,826 62,646,726 RGD:6907045
G HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 JBrowse link 16 56,932,142 56,944,864 RGD:6907045
G HSP90AA1 heat shock protein 90 alpha family class A member 1 JBrowse link 14 102,080,742 102,139,749 RGD:6907045
G HSP90AB1 heat shock protein 90 alpha family class B member 1 JBrowse link 6 44,246,166 44,253,888 RGD:6907045
G HSP90B1 heat shock protein 90 beta family member 1 JBrowse link 12 103,930,410 103,947,926 RGD:6907045
G HSPA1A heat shock protein family A (Hsp70) member 1A JBrowse link 6 31,815,543 31,817,942 RGD:6907045
G HSPA1B heat shock protein family A (Hsp70) member 1B JBrowse link 6 31,827,738 31,830,254 RGD:6907045
G HSPA1L heat shock protein family A (Hsp70) member 1 like JBrowse link 6 31,809,619 31,815,283 RGD:6907045
G HSPA2 heat shock protein family A (Hsp70) member 2 JBrowse link 14 64,540,468 64,543,237 RGD:6907045
G HSPA4L heat shock protein family A (Hsp70) member 4 like JBrowse link 4 127,781,796 127,840,733 RGD:6907045
G HSPA5 heat shock protein family A (Hsp70) member 5 JBrowse link 9 125,234,853 125,241,343 RGD:6907045
G HSPA6 heat shock protein family A (Hsp70) member 6 JBrowse link 1 161,524,540 161,526,894 RGD:6907045
G HSPA8 heat shock protein family A (Hsp70) member 8 JBrowse link 11 123,057,489 123,062,366 RGD:6907045
G HSPBP1 HSPA (Hsp70) binding protein 1 JBrowse link 19 55,262,223 55,280,423 RGD:6907045
G HSPH1 heat shock protein family H (Hsp110) member 1 JBrowse link 13 31,134,973 31,162,388 RGD:6907045
G HYOU1 hypoxia up-regulated 1 JBrowse link 11 119,044,187 119,057,205 RGD:6907045
G LMAN1 lectin, mannose binding 1 JBrowse link 18 59,327,823 59,359,265 RGD:6907045
G LMAN1L lectin, mannose binding 1 like JBrowse link 15 74,812,835 74,825,754 RGD:6907045
G LMAN2 lectin, mannose binding 2 JBrowse link 5 177,331,567 177,351,668 RGD:6907045
G MAN1A1 mannosidase alpha class 1A member 1 JBrowse link 6 119,177,204 119,350,619 RGD:6907045
G MAN1A2 mannosidase alpha class 1A member 2 JBrowse link 1 117,367,393 117,528,872 RGD:6907045
G MAN1B1 mannosidase alpha class 1B member 1 JBrowse link 9 137,086,941 137,109,183 RGD:6907045
G MAN1C1 mannosidase alpha class 1C member 1 JBrowse link 1 25,616,820 25,786,207 RGD:6907045
G MAP2K7 mitogen-activated protein kinase kinase 7 JBrowse link 19 7,903,785 7,914,478 RGD:6907045
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 6 136,557,046 136,793,098 RGD:6907045
G MAPK10 mitogen-activated protein kinase 10 JBrowse link 4 86,010,405 86,594,625 RGD:6907045
G MAPK8 mitogen-activated protein kinase 8 JBrowse link 10 48,306,639 48,439,360 RGD:6907045
G MAPK9 mitogen-activated protein kinase 9 JBrowse link 5 180,233,143 180,292,083 RGD:6907045
G MARCHF6 membrane associated ring-CH-type finger 6 JBrowse link 5 10,353,693 10,440,388 RGD:6907045
G MBTPS1 membrane bound transcription factor peptidase, site 1 JBrowse link 16 84,053,763 84,116,942 RGD:6907045
G MBTPS2 membrane bound transcription factor peptidase, site 2 JBrowse link X 21,839,617 21,885,423 RGD:6907045
G MOGS mannosyl-oligosaccharide glucosidase JBrowse link 2 74,461,057 74,465,382 RGD:6907045
G NFE2L2 nuclear factor, erythroid 2 like 2 JBrowse link 2 177,230,303 177,265,131 RGD:6907045
G NGLY1 N-glycanase 1 JBrowse link 3 25,718,944 25,790,039 RGD:6907045
G NPLOC4 NPL4 homolog, ubiquitin recognition factor JBrowse link 17 81,556,885 81,637,148 RGD:6907045
G NSFL1C NSFL1 cofactor JBrowse link 20 1,442,162 1,467,793 RGD:6907045
G OS9 OS9 endoplasmic reticulum lectin JBrowse link 12 57,693,955 57,721,557 RGD:6907045
G P4HB prolyl 4-hydroxylase subunit beta JBrowse link 17 81,843,159 81,860,535 RGD:6907045
G PDIA3 protein disulfide isomerase family A member 3 JBrowse link 15 43,746,438 43,773,278 RGD:6907045
G PDIA4 protein disulfide isomerase family A member 4 JBrowse link 7 149,003,051 149,028,505 RGD:6907045
G PDIA6 protein disulfide isomerase family A member 6 JBrowse link 2 10,783,391 10,837,712 RGD:6907045
G PLAA phospholipase A2 activating protein JBrowse link 9 26,903,372 26,947,473 RGD:6907045
G PPP1R15A protein phosphatase 1 regulatory subunit 15A JBrowse link 19 48,872,392 48,876,062 RGD:6907045
G PREB prolactin regulatory element binding JBrowse link 2 27,130,756 27,134,675 RGD:6907045
G PRKCSH protein kinase C substrate 80K-H JBrowse link 19 11,435,257 11,450,968 RGD:6907045
G PRKN parkin RBR E3 ubiquitin protein ligase JBrowse link 6 161,347,417 162,727,802 RGD:6907045
G RAD23A RAD23 homolog A, nucleotide excision repair protein JBrowse link 19 12,945,814 12,953,643 RGD:6907045
G RAD23B RAD23 homolog B, nucleotide excision repair protein JBrowse link 9 107,283,279 107,332,194 RGD:6907045
G RBX1 ring-box 1 JBrowse link 22 40,951,378 40,973,309 RGD:6907045
G RNF5 ring finger protein 5 JBrowse link 6 32,178,405 32,180,793 RGD:6907045
G RPN1 ribophorin I JBrowse link 3 128,619,969 128,650,818 RGD:6907045
G RPN2 ribophorin II JBrowse link 20 37,179,046 37,241,623 RGD:6907045
G RRBP1 ribosome binding protein 1 JBrowse link 20 17,613,678 17,682,283 RGD:6907045
G SAR1A secretion associated Ras related GTPase 1A JBrowse link 10 70,147,289 70,170,514 RGD:6907045
G SAR1B secretion associated Ras related GTPase 1B JBrowse link 5 134,601,149 134,632,828 RGD:6907045
G SEC13 SEC13 homolog, nuclear pore and COPII coat complex component JBrowse link 3 10,300,929 10,321,188 RGD:6907045
G SEC23A Sec23 homolog A, COPII coat complex component JBrowse link 14 39,031,919 39,103,235 RGD:6907045
G SEC23B SEC23 homolog B, COPII coat complex component JBrowse link 20 18,507,482 18,561,415 RGD:6907045
G SEC24A SEC24 homolog A, COPII coat complex component JBrowse link 5 134,647,757 134,727,909 RGD:6907045
G SEC24B SEC24 homolog B, COPII coat complex component JBrowse link 4 109,433,715 109,540,896 RGD:6907045
G SEC24C SEC24 homolog C, COPII coat complex component JBrowse link 10 73,744,164 73,772,167 RGD:6907045
G SEC24D SEC24 homolog D, COPII coat complex component JBrowse link 4 118,722,823 118,838,683 RGD:6907045
G SEC31A SEC31 homolog A, COPII coat complex component JBrowse link 4 82,818,509 82,900,571 RGD:6907045
G SEC31B SEC31 homolog B, COPII coat complex component JBrowse link 10 100,486,647 100,519,861 RGD:6907045
G SEC61A1 SEC61 translocon subunit alpha 1 JBrowse link 3 128,052,437 128,071,683 RGD:6907045
G SEC61A2 SEC61 translocon subunit alpha 2 JBrowse link 10 12,129,641 12,169,958 RGD:6907045
G SEC61B SEC61 translocon subunit beta JBrowse link 9 99,222,282 99,230,615 RGD:6907045
G SEC61G SEC61 translocon subunit gamma JBrowse link 7 54,752,247 54,759,246 RGD:6907045
G SEC62 SEC62 homolog, preprotein translocation factor JBrowse link 3 169,966,136 169,998,373 RGD:6907045
G SEC63 SEC63 homolog, protein translocation regulator JBrowse link 6 107,867,756 107,958,208 RGD:6907045
G SEL1L SEL1L adaptor subunit of ERAD E3 ubiquitin ligase JBrowse link 14 81,471,547 81,533,861 RGD:6907045
G SIL1 SIL1 nucleotide exchange factor JBrowse link 5 138,946,724 139,198,368 RGD:6907045
G SKP1 S-phase kinase associated protein 1 JBrowse link 5 134,148,935 134,177,033 RGD:6907045
G SSR1 signal sequence receptor subunit 1 JBrowse link 6 7,281,143 7,313,199 RGD:6907045
G SSR2 signal sequence receptor subunit 2 JBrowse link 1 156,009,048 156,020,951 RGD:6907045
G SSR3 signal sequence receptor subunit 3 JBrowse link 3 156,539,553 156,555,200 RGD:6907045
G SSR4 signal sequence receptor subunit 4 JBrowse link X 153,794,159 153,798,512 RGD:6907045
G STT3A STT3 oligosaccharyltransferase complex catalytic subunit A JBrowse link 11 125,592,847 125,623,091 RGD:6907045
G STT3B STT3 oligosaccharyltransferase complex catalytic subunit B JBrowse link 3 31,532,638 31,637,621 RGD:6907045
G STUB1 STIP1 homology and U-box containing protein 1 JBrowse link 16 680,410 682,801 RGD:6907045
G SVIP small VCP interacting protein JBrowse link 11 22,812,429 22,829,865 RGD:6907045
G SYVN1 synoviolin 1 JBrowse link 11 65,127,279 65,135,178 RGD:6907045
G TRAF2 TNF receptor associated factor 2 JBrowse link 9 136,881,933 136,926,615 RGD:6907045
G TRAM1 translocation associated membrane protein 1 JBrowse link 8 70,573,218 70,608,453 RGD:6907045
G TUSC3 tumor suppressor candidate 3 JBrowse link 8 15,540,087 15,766,649 RGD:6907045
G TXNDC5 thioredoxin domain containing 5 JBrowse link 6 7,881,514 7,910,788 RGD:6907045
G UBE2D1 ubiquitin conjugating enzyme E2 D1 JBrowse link 10 58,334,979 58,370,753 RGD:6907045
G UBE2D2 ubiquitin conjugating enzyme E2 D2 JBrowse link 5 139,561,166 139,628,434 RGD:6907045
G UBE2D3 ubiquitin conjugating enzyme E2 D3 JBrowse link 4 102,794,383 102,868,893 RGD:6907045
G UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) JBrowse link 7 43,926,422 43,956,136 RGD:6907045
G UBE2E1 ubiquitin conjugating enzyme E2 E1 JBrowse link 3 23,805,955 23,891,640 RGD:6907045
G UBE2E2 ubiquitin conjugating enzyme E2 E2 JBrowse link 3 23,203,007 23,591,925 RGD:6907045
G UBE2E3 ubiquitin conjugating enzyme E2 E3 JBrowse link 2 180,980,385 181,063,427 RGD:6907045
G UBE2G1 ubiquitin conjugating enzyme E2 G1 JBrowse link 17 4,269,217 4,366,674 RGD:6907045
G UBE2G2 ubiquitin conjugating enzyme E2 G2 JBrowse link 21 44,768,580 44,801,820 RGD:6907045
G UBE2J1 ubiquitin conjugating enzyme E2 J1 JBrowse link 6 89,326,625 89,353,155 RGD:6907045
G UBE2J2 ubiquitin conjugating enzyme E2 J2 JBrowse link 1 1,253,912 1,273,854 RGD:6907045
G UBE4B ubiquitination factor E4B JBrowse link 1 10,032,958 10,181,239 RGD:6907045
G UBQLN1 ubiquilin 1 JBrowse link 9 83,659,968 83,707,979 RGD:6907045
G UBQLN2 ubiquilin 2 JBrowse link X 56,563,627 56,567,868 RGD:6907045
G UBQLN3 ubiquilin 3 JBrowse link 11 5,507,300 5,509,957 RGD:6907045
G UBQLN4 ubiquilin 4 JBrowse link 1 156,033,129 156,053,798 RGD:6907045
G UBQLNL ubiquilin like JBrowse link 11 5,514,393 5,516,699 RGD:6907045
G UBXN6 UBX domain protein 6 JBrowse link 19 4,445,006 4,458,759 RGD:6907045
G UFD1 ubiquitin recognition factor in ER associated degradation 1 JBrowse link 22 19,449,911 19,479,193 RGD:6907045
G UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 JBrowse link 2 128,091,184 128,195,677 RGD:6907045
G UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 JBrowse link 13 95,801,580 96,053,437 RGD:6907045
G VCP valosin containing protein JBrowse link 9 35,056,064 35,072,668 RGD:6907045
G WFS1 wolframin ER transmembrane glycoprotein JBrowse link 4 6,260,368 6,303,265 RGD:6907045
G XBP1 X-box binding protein 1 JBrowse link 22 28,794,560 28,800,572 RGD:6907045
G YOD1 YOD1 deubiquitinase JBrowse link 1 207,043,849 207,052,980 RGD:6907045

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5944
    regulatory pathway 3597
      pathway pertinent to protein folding, sorting, modification, translocation and degradation 330
        protein degradation pathway 328
          Endoplasmic Reticulum-associated degradation pathway 164
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.