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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:altered transforming growth factor-beta Smad dependent signaling pathway
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Accession:PW:0000614 term browser browse the term
Definition:A transfoming growth factor-beta Smad dependent signaling pathway that deviates from what its normal course should be. Altered TGF-beta Smad dependent signaling has been implicated in vascular conditions and tumorigenesis.
Synonyms:related_synonym: altered TGF-beta Smad dependent signaling pathway
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altered transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SMAD2 SMAD family member 2 ISO RGD PMID:17613544 PMID:18662538 RGD:2306282 RGD:2308865 NCBI chr18:41,213,001...41,309,902
Ensembl chr18:44,580,905...44,668,530 		JBrowse link
G SMAD3 SMAD family member 3 ISO RGD PMID:17613544 PMID:18772397 RGD:2306282 RGD:5490966 NCBI chr15:46,013,764...46,143,126
Ensembl chr15:64,284,949...64,414,185 		JBrowse link
G SMAD4 SMAD family member 4 ISO RGD PMID:17613544 PMID:18662538 PMID:18772397 PMID:19506583 RGD:2306282 RGD:2308865 RGD:5490965 RGD:5490966 NCBI chr18:44,402,112...44,456,779
Ensembl chr18:47,764,568...47,797,359 		JBrowse link
G SMAD7 SMAD family member 7 ISO RGD PMID:18662538 RGD:2308865 NCBI chr18:42,306,324...42,337,214 JBrowse link
G TGFB1 transforming growth factor beta 1 ISO RGD PMID:17613544 PMID:18313409 RGD:2299005 RGD:2306282 NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 ISO RGD PMID:17613544 PMID:18313409 RGD:2299005 RGD:2306282 NCBI chr 9:70,195,007...70,243,514
Ensembl chr 9:98,332,739...98,362,748 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 ISO RGD PMID:17613544 PMID:18313409 PMID:18662538 PMID:18772397 PMID:19506583 RGD:2299005 RGD:2306282 RGD:2308865 RGD:5490965 RGD:5490966 NCBI chr 3:30,536,187...30,623,653
Ensembl chr 3:30,854,460...30,938,856 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4069
    signaling pathway 1942
      altered signaling pathway 102
        altered signaling pathway pertinent to development 29
          altered transforming growth factor-beta Smad dependent signaling pathway 7
Path 2
Term Annotations click to browse term
  pathway 4069
    signaling pathway 1942
      growth factor signaling pathway 373
        transforming growth factor-beta superfamily mediated signaling pathway 104
          transforming growth factor-beta signaling pathway 68
            transforming growth factor-beta Smad dependent signaling pathway 66
              altered transforming growth factor-beta Smad dependent signaling pathway 7
paths to the root