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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:endometrial cancer pathway
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Accession:PW:0000611 term browser browse the term
Definition:Endometrial cancer affects the lining of the uterus, or endometrium. Hormonal and genetic alterations play a role in the development of this carcinoma type. Mutations in genes acting in several pathways have been associated with the condition and its types.
Synonyms:related_synonym: KEGG:05213;   endometrial neoplasm pathway
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endometrial cancer pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 IEA KEGG mmu:05213 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Akt2 thymoma viral proto-oncogene 2 severity IEA
ISO		 KEGG
RGD		 PMID:22146979 mmu:05213, RGD:13432140 NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251 		JBrowse link
G Akt3 thymoma viral proto-oncogene 3 IEA KEGG mmu:05213 NCBI chr 1:176,847,642...177,091,688
Ensembl chr 1:176,847,639...177,085,769 		JBrowse link
G Apc APC, WNT signaling pathway regulator IEA
ISO		 KEGG
RGD		 PMID:12439748 mmu:05213, RGD:13432145 NCBI chr18:34,353,350...34,455,243
Ensembl chr18:34,353,977...34,455,605 		JBrowse link
G Apc2 APC regulator of WNT signaling pathway 2 IEA KEGG mmu:05213 NCBI chr10:80,131,790...80,154,091
Ensembl chr10:80,131,811...80,154,097 		JBrowse link
G Araf Araf proto-oncogene, serine/threonine kinase IEA KEGG mmu:05213 NCBI chr  X:20,663,946...20,726,760
Ensembl chr  X:20,664,053...20,726,758 		JBrowse link
G Axin1 axin 1 IEA KEGG mmu:05213 NCBI chr17:26,350,294...26,414,784
Ensembl chr17:26,357,662...26,414,785 		JBrowse link
G Axin2 axin 2 IEA
ISO		 KEGG
RGD		 PMID:25144715 mmu:05213, RGD:13432159 NCBI chr11:108,808,687...108,841,609
Ensembl chr11:108,811,175...108,841,609 		JBrowse link
G Bad BCL2-associated agonist of cell death IEA
ISO		 KEGG
RGD		 PMID:12790783 mmu:05213, RGD:13432162 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267 		JBrowse link
G Braf Braf transforming gene IEA KEGG mmu:05213 NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397 		JBrowse link
G Casp9 caspase 9 IEA
ISO		 KEGG
RGD		 PMID:17121923 mmu:05213, RGD:13432196 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Ccnd1 cyclin D1 IEA KEGG mmu:05213 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Cdh1 cadherin 1 IEA KEGG mmu:05213 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Ctnna1 catenin alpha 1 IEA KEGG mmu:05213 NCBI chr18:35,251,955...35,387,829
Ensembl chr18:35,251,912...35,387,832 		JBrowse link
G Ctnna2 catenin alpha 2 IEA KEGG mmu:05213 NCBI chr 6:76,858,620...77,956,798
Ensembl chr 6:76,858,620...77,956,682 		JBrowse link
G Ctnna3 catenin alpha 3 IEA KEGG mmu:05213 NCBI chr10:63,265,877...64,841,174
Ensembl chr10:63,265,877...64,839,446 		JBrowse link
G Ctnnb1 catenin beta 1 ISO
IEA		 KEGG
RGD		 PMID:19078924 mmu:05213, RGD:4143515 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Egf epidermal growth factor IEA KEGG mmu:05213 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965 		JBrowse link
G Egfr epidermal growth factor receptor IEA KEGG mmu:05213 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Elk1 ELK1, member of ETS oncogene family IEA KEGG mmu:05213 NCBI chr  X:20,799,634...20,816,847
Ensembl chr  X:20,799,634...20,816,847 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO
IEA		 KEGG
RGD		 PMID:19078924 mmu:05213, RGD:4143515 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542 		JBrowse link
G Foxo3 forkhead box O3 IEA KEGG mmu:05213 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751 		JBrowse link
G Grb2 growth factor receptor bound protein 2 IEA KEGG mmu:05213 NCBI chr11:115,534,871...115,599,423
Ensembl chr11:115,534,871...115,599,423 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IEA KEGG mmu:05213 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Hras Harvey rat sarcoma virus oncogene IEA KEGG mmu:05213 NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918 		JBrowse link
G Ilk integrin linked kinase IEA KEGG mmu:05213 NCBI chr 7:105,385,797...105,392,132
Ensembl chr 7:105,385,799...105,392,132 		JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog ISO
IEA		 KEGG
RGD		 PMID:19078924 mmu:05213, RGD:4143515 NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 IEA KEGG mmu:05213 NCBI chr 3:130,903,972...131,018,006
Ensembl chr 3:130,904,120...131,018,005 		JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 IEA KEGG mmu:05213 NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913 		JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 IEA KEGG mmu:05213 NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 IEA KEGG mmu:05213 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 IEA KEGG mmu:05213 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mlh1 mutL homolog 1 ISO
IEA		 KEGG
RGD		 PMID:19078924 mmu:05213, RGD:4143515 NCBI chr 9:111,057,296...111,100,854
Ensembl chr 9:111,057,296...111,100,859 		JBrowse link
G Msh6 mutS homolog 6 ISO RGD PMID:19078924 RGD:4143515 NCBI chr17:88,282,478...88,298,320
Ensembl chr17:88,282,490...88,298,320 		JBrowse link
G Myc myelocytomatosis oncogene IEA KEGG mmu:05213 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Nras neuroblastoma ras oncogene IEA KEGG mmu:05213 NCBI chr 3:102,965,643...102,975,230
Ensembl chr 3:102,965,601...102,975,230 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 IEA KEGG mmu:05213 NCBI chr17:24,292,654...24,370,957
Ensembl chr17:24,292,654...24,369,898 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO
IEA		 KEGG
RGD		 PMID:19078924 mmu:05213, RGD:4143515 NCBI chr 3:32,451,203...32,520,256
Ensembl chr 3:32,451,820...32,522,635 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta IEA KEGG mmu:05213 NCBI chr 9:98,920,455...99,022,264
Ensembl chr 9:98,918,707...99,022,674 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta IEA KEGG mmu:05213 NCBI chr 4:149,733,625...149,787,023
Ensembl chr 4:149,733,625...149,787,028 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IEA KEGG mmu:05213 NCBI chr12:32,223,128...32,258,675
Ensembl chr12:32,223,472...32,258,658 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IEA KEGG mmu:05213 NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG mmu:05213 NCBI chr 8:71,220,820...71,229,356
Ensembl chr 8:71,220,820...71,229,357 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG mmu:05213 NCBI chr 4:116,078,593...116,160,253
Ensembl chr 4:116,078,815...116,160,253
Ensembl chr 4:116,078,815...116,160,253 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase regulatory subunit 5 IEA KEGG mmu:05213 NCBI chr11:68,322,951...68,388,675
Ensembl chr11:68,322,947...68,388,675 		JBrowse link
G Pten phosphatase and tensin homolog ISO
IEA		 KEGG
RGD		 PMID:19078924 mmu:05213, RGD:4143515 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 IEA KEGG mmu:05213 NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IEA KEGG mmu:05213 NCBI chr17:80,701,181...80,787,882
Ensembl chr17:80,701,180...80,787,882 		JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 IEA KEGG mmu:05213 NCBI chr12:69,630,535...69,728,626
Ensembl chr12:69,630,536...69,728,626 		JBrowse link
G Tcf7 transcription factor 7, T cell specific IEA KEGG mmu:05213 NCBI chr11:52,137,347...52,174,211
Ensembl chr11:52,143,198...52,174,158 		JBrowse link
G Tcf7l1 transcription factor 7 like 1 (T cell specific, HMG box) IEA KEGG mmu:05213 NCBI chr 6:72,603,354...72,766,028
Ensembl chr 6:72,603,361...72,766,237 		JBrowse link
G Tcf7l2 transcription factor 7 like 2, T cell specific, HMG box IEA KEGG mmu:05213 NCBI chr19:55,730,227...55,922,091
Ensembl chr19:55,730,252...55,922,086 		JBrowse link
G Trp53 transformation related protein 53 ISO
IEA		 KEGG
RGD		 PMID:19078924 mmu:05213, RGD:4143515 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6072
    disease pathway 2094
      cancer pathway 390
        urogenital cancer pathway 167
          endometrial cancer pathway 53
paths to the root