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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:altered Wnt signaling, canonical pathway
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Accession:PW:0000599 term browser browse the term
Definition:A canonical Wnt signaling pathway that deviates from what its normal course should be. Mutations in core components of the canonical pathway have been implicated in several types of cancer as well as diseases other than cancer.
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altered Wnt signaling, canonical pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway ISO RGD PMID:18432252 RGD:2293188 NCBI chr18:26,138,382...26,196,021
Ensembl chr18:26,102,679...26,197,022 		JBrowse link
G Axin1 axin 1 ISO RGD PMID:18432252 RGD:2293188 NCBI chr10:15,667,894...15,720,092
Ensembl chr10:15,667,958...15,720,092 		JBrowse link
G Axin2 axin 2 ISO RGD PMID:18432252 RGD:2293188 NCBI chr10:94,393,379...94,426,579
Ensembl chr10:94,395,909...94,426,575 		JBrowse link
G Ctnnb1 catenin beta 1 ISO RGD PMID:18432252 PMID:19078924 RGD:2293188, RGD:4143515 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Lrp5 LDL receptor related protein 5 ISO RGD PMID:18432252 RGD:2293188 NCBI chr 1:210,243,499...210,346,886
Ensembl chr 1:210,243,502...210,346,822 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 IMP RGD PMID:20128690 RGD:150573713 NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:45,081,889...45,149,897 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 ISO RGD PMID:18772397 RGD:5490966 NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:264,791,335...264,984,225 		JBrowse link
G Wnt9a Wnt family member 9A ISO RGD PMID:18772397 RGD:5490966 NCBI chr10:44,593,691...44,620,682
Ensembl chr10:44,593,691...44,620,682 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      altered signaling pathway 115
        altered signaling pathway pertinent to development 33
          altered Wnt signaling pathway 8
            altered Wnt signaling, canonical pathway 8
Path 2
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      glycoconjugated protein signaling pathway 416
        glycoprotein signaling pathway 300
          altered glycoprotein signaling pathway 30
            altered Wnt signaling pathway 8
              altered Wnt signaling, canonical pathway 8
paths to the root