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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:eicosanoid signaling pathway
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Accession:PW:0000565 term browser browse the term
Definition:Eicosanoids, derived from omega-3 or omega-6 fatty acids, are represented by the leukotriene and prostanoid classes of which the latter is represented by several families. Some can act as endogenous ligands for members of the peroxisomal proliferator-activated nuclear receptors (PPARs). Once activated, PPARs heterodimerize with the retinoid X receptor (RXR) and modulate the expression of target genes.
Synonyms:related_synonym: PID:200082
 alt_id: PW:0001294


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eicosanoid signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200082 NCBI chrNW_004955538:3,208,711...3,224,386
Ensembl chrNW_004955538:3,208,710...3,229,904
JBrowse link
G Arhgef1 Rho guanine nucleotide exchange factor 1 ISO PID PID:200082 NCBI chrNW_004955555:941,539...961,407 JBrowse link
G Arr3 arrestin 3 ISO PID PID:200082 NCBI chrNW_004955475:9,819,783...9,835,526
Ensembl chrNW_004955475:9,819,792...9,835,200
JBrowse link
G Arrb2 arrestin beta 2 ISO PID PID:200082 NCBI chrNW_004955467:10,109,985...10,118,687
Ensembl chrNW_004955467:10,110,003...10,123,022
JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase ISO PID PID:200082 NCBI chrNW_004955403:52,825,397...52,874,007
Ensembl chrNW_004955403:52,832,604...52,874,264
JBrowse link
G Dnm1 dynamin 1 ISO PID PID:200082 NCBI chrNW_004955570:752,335...781,770
Ensembl chrNW_004955570:752,335...781,770
JBrowse link
G Egf epidermal growth factor ISO PID PID:200082 NCBI chrNW_004955496:325,954...401,430
Ensembl chrNW_004955496:328,075...401,569
JBrowse link
G Egfr epidermal growth factor receptor ISO PID PID:200082 NCBI chrNW_004955456:321,222...456,431 JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase ISO PID PID:200082 NCBI chrNW_004955452:6,840,274...6,863,460
Ensembl chrNW_004955452:6,841,802...6,863,542
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase ISO PID PID:200082 NCBI chrNW_004955411:36,403,156...36,597,660
Ensembl chrNW_004955411:36,401,842...36,512,054
JBrowse link
G Gna11 G protein subunit alpha 11 ISO PID PID:200082 NCBI chrNW_004955495:5,286,891...5,302,631
Ensembl chrNW_004955495:5,285,380...5,302,631
JBrowse link
G Gna12 G protein subunit alpha 12 ISO PID PID:200082 NCBI chrNW_004955460:12,534,210...12,628,090
Ensembl chrNW_004955460:12,534,168...12,622,537
JBrowse link
G Gna13 G protein subunit alpha 13 ISO PID PID:200082 NCBI chrNW_004955478:4,510,932...4,552,646
Ensembl chrNW_004955478:4,515,751...4,552,784
JBrowse link
G Gna14 G protein subunit alpha 14 ISO PID PID:200082 NCBI chrNW_004955512:1,703,750...1,918,321
Ensembl chrNW_004955512:1,707,503...1,917,513
JBrowse link
G Gna15 G protein subunit alpha 15 ISO PID PID:200082 NCBI chrNW_004955495:5,254,546...5,270,864
Ensembl chrNW_004955495:5,252,547...5,270,894
JBrowse link
G Gnai2 G protein subunit alpha i2 ISO PID PID:200082 NCBI chrNW_004955532:2,059,038...2,079,120
Ensembl chrNW_004955532:2,059,038...2,079,957
JBrowse link
G Gnaq G protein subunit alpha q ISO PID PID:200082 NCBI chrNW_004955512:1,381,159...1,658,409 JBrowse link
G Gnb1 G protein subunit beta 1 ISO PID PID:200082 NCBI chrNW_004955486:9,165,850...9,192,306
Ensembl chrNW_004955486:9,165,850...9,193,066
JBrowse link
G Gnb5 G protein subunit beta 5 ISO PID PID:200082 NCBI chrNW_004955409:2,621,144...2,642,298
Ensembl chrNW_004955409:2,619,718...2,641,308
JBrowse link
G Gng2 G protein subunit gamma 2 ISO PID PID:200082 NCBI chrNW_004955409:11,075,455...11,178,993
Ensembl chrNW_004955409:11,075,455...11,088,455
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO PID PID:200082 NCBI chrNW_004955422:18,173,438...18,192,357
Ensembl chrNW_004955422:18,170,616...18,192,412
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO PID PID:200082 NCBI chrNW_004955442:19,640,145...19,785,803
Ensembl chrNW_004955442:19,640,145...19,785,803
JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase ISO PID PID:200082 NCBI chrNW_004955422:28,934,512...28,986,998
Ensembl chrNW_004955422:28,932,653...28,986,998
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO PID PID:200082 NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase ISO PID PID:200082 NCBI chrNW_004955452:10,608,317...10,632,310
Ensembl chrNW_004955452:10,608,318...10,632,310
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase ISO PID PID:200082 NCBI chrNW_004955454:15,025,967...15,111,142
Ensembl chrNW_004955454:15,035,979...15,111,142
JBrowse link
G Mapk11 mitogen-activated protein kinase 11 ISO PID PID:200082 NCBI chrNW_004955413:33,287,860...33,293,948
Ensembl chrNW_004955413:33,286,390...33,294,227
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 ISO PID PID:200082 NCBI chrNW_004955437:3,836,331...3,884,083
Ensembl chrNW_004955437:3,838,232...3,884,083
JBrowse link
G Nos3 nitric oxide synthase 3 ISO PID PID:200082 NCBI chrNW_004955491:5,438,228...5,457,308
Ensembl chrNW_004955491:5,438,010...5,460,814
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO PID PID:200082 NCBI chrNW_004955410:11,402,476...11,433,335
Ensembl chrNW_004955410:11,402,520...11,437,422
JBrowse link
G Pik3r5 phosphoinositide-3-kinase regulatory subunit 5 ISO PID PID:200082 NCBI chrNW_004955467:8,025,231...8,091,406
Ensembl chrNW_004955467:8,065,857...8,091,486
JBrowse link
G Pik3r6 phosphoinositide-3-kinase regulatory subunit 6 ISO PID PID:200082 NCBI chrNW_004955467:8,104,242...8,157,637
Ensembl chrNW_004955467:8,104,906...8,157,144
JBrowse link
G Plcb2 phospholipase C beta 2 ISO PID PID:200082 NCBI chrNW_004955416:7,221,326...7,240,743
Ensembl chrNW_004955416:7,218,417...7,240,739
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha ISO PID PID:200082 NCBI chrNW_004955415:32,794,172...32,807,944
Ensembl chrNW_004955415:32,793,718...32,812,930
JBrowse link
G Prkca protein kinase C alpha ISO PID PID:200082 NCBI chrNW_004955478:5,686,639...6,090,356
Ensembl chrNW_004955478:5,686,640...6,083,967
JBrowse link
G Prkcd protein kinase C delta ISO PID PID:200082 NCBI chrNW_004955430:3,125,066...3,151,857
Ensembl chrNW_004955430:3,124,738...3,153,274
JBrowse link
G Prkce protein kinase C epsilon ISO PID PID:200082 NCBI chrNW_004955441:12,642,703...13,142,396
Ensembl chrNW_004955441:12,642,697...13,139,372
JBrowse link
G Prkcg protein kinase C gamma ISO PID PID:200082 NCBI chrNW_004955604:262,182...279,259
Ensembl chrNW_004955604:262,071...279,259
JBrowse link
G Prkch protein kinase C eta ISO PID PID:200082 NCBI chrNW_004955466:8,178,323...8,393,446 JBrowse link
G Prkcq protein kinase C theta ISO PID PID:200082 NCBI chrNW_004955421:23,072,607...23,151,591
Ensembl chrNW_004955421:23,070,955...23,175,699
JBrowse link
G Prkcz protein kinase C zeta ISO PID PID:200082 NCBI chrNW_004955486:8,947,579...9,021,702
Ensembl chrNW_004955486:8,947,579...9,021,702
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 ISO PID PID:200082 NCBI chrNW_004955425:6,176,335...7,335,867
Ensembl chrNW_004955425:6,176,432...7,331,446
JBrowse link
G Ptgdr prostaglandin D2 receptor ISO PID PID:200082 NCBI chrNW_004955409:10,801,370...10,810,161
Ensembl chrNW_004955409:10,801,328...10,810,066
JBrowse link
G Ptgir prostaglandin I2 receptor ISO PID PID:200082 NCBI chrNW_004955574:686,156...690,126
Ensembl chrNW_004955574:687,583...689,750
JBrowse link
G Rab11a RAB11A, member RAS oncogene family ISO PID PID:200082 NCBI chrNW_004955450:9,638,761...9,656,291
Ensembl chrNW_004955450:9,638,761...9,656,603
JBrowse link
G Rac1 Rac family small GTPase 1 ISO PID PID:200082 NCBI chrNW_004955460:13,270,159...13,295,562
Ensembl chrNW_004955460:13,270,159...13,311,351
JBrowse link
G Rhoa ras homolog family member A ISO PID PID:200082 NCBI chrNW_004955532:1,300,821...1,347,453
Ensembl chrNW_004955532:1,300,462...1,347,451
JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 ISO PID PID:200082 NCBI chrNW_004955402:9,752,101...9,864,317
Ensembl chrNW_004955402:9,750,730...9,864,317
JBrowse link
G Sele selectin E ISO PID PID:200082 NCBI chrNW_004955462:7,564,437...7,575,297 JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 ISO PID PID:200082 NCBI chrNW_004955553:1,639,267...1,656,850
Ensembl chrNW_004955553:1,639,267...1,656,850
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO PID PID:200082 NCBI chrNW_004955445:19,213,210...19,227,670
Ensembl chrNW_004955445:19,215,161...19,228,695
JBrowse link
G Syk spleen associated tyrosine kinase ISO PID PID:200082 NCBI chrNW_004955515:1,328,793...1,400,206
Ensembl chrNW_004955515:1,328,630...1,380,581
JBrowse link
G Tbxa2r thromboxane A2 receptor ISO PID PID:200082 NCBI chrNW_004955495:5,539,382...5,557,441
Ensembl chrNW_004955495:5,539,889...5,557,441
JBrowse link
G Tgm2 transglutaminase 2 ISO PID PID:200082 NCBI chrNW_004955445:18,544,192...18,576,576
Ensembl chrNW_004955445:18,544,183...18,576,570
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO PID PID:200082 NCBI chrNW_004955435:5,390,745...5,410,025
Ensembl chrNW_004955435:5,390,751...5,411,691
JBrowse link
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase ISO PID PID:200082 NCBI chrNW_004955402:9,199,704...9,255,183
Ensembl chrNW_004955402:9,226,295...9,256,044
JBrowse link
prostaglandin D2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy2 adenylate cyclase 2 ISO SMPDB SMP:00343 NCBI chrNW_004955504:4,990,634...5,376,990
Ensembl chrNW_004955504:5,004,903...5,376,328
JBrowse link
G Gnb1 G protein subunit beta 1 ISO SMPDB SMP:00343 NCBI chrNW_004955486:9,165,850...9,192,306
Ensembl chrNW_004955486:9,165,850...9,193,066
JBrowse link
G Gng12 G protein subunit gamma 12 ISO SMPDB SMP:00343 NCBI chrNW_004955423:23,576,515...23,644,600
Ensembl chrNW_004955423:23,634,402...23,644,600
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta ISO SMPDB SMP:00343 NCBI chrNW_004955423:9,630,308...9,747,820
Ensembl chrNW_004955423:9,629,378...9,747,820
JBrowse link
G Ptgdr prostaglandin D2 receptor ISO SMPDB SMP:00343 NCBI chrNW_004955409:10,801,370...10,810,161
Ensembl chrNW_004955409:10,801,328...10,810,066
JBrowse link
prostaglandin I2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy2 adenylate cyclase 2 ISO SMPDB SMP:00354 NCBI chrNW_004955504:4,990,634...5,376,990
Ensembl chrNW_004955504:5,004,903...5,376,328
JBrowse link
G Gnb1 G protein subunit beta 1 ISO SMPDB SMP:00354 NCBI chrNW_004955486:9,165,850...9,192,306
Ensembl chrNW_004955486:9,165,850...9,193,066
JBrowse link
G Gng12 G protein subunit gamma 12 ISO SMPDB SMP:00354 NCBI chrNW_004955423:23,576,515...23,644,600
Ensembl chrNW_004955423:23,634,402...23,644,600
JBrowse link
G Myl3 myosin light chain 3 ISO SMPDB SMP:00354 NCBI chrNW_004955420:25,308,513...25,311,959
Ensembl chrNW_004955420:25,305,759...25,312,271
JBrowse link
G Mylk myosin light chain kinase ISO SMPDB SMP:00354 NCBI chrNW_004955427:22,760,432...23,008,432
Ensembl chrNW_004955427:22,762,221...22,970,508
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta ISO SMPDB SMP:00354 NCBI chrNW_004955423:9,630,308...9,747,820
Ensembl chrNW_004955423:9,629,378...9,747,820
JBrowse link
G Ptgir prostaglandin I2 receptor ISO SMPDB SMP:00354 NCBI chrNW_004955574:686,156...690,126
Ensembl chrNW_004955574:687,583...689,750
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3928
    signaling pathway 1887
      lipid signaling pathway 154
        eicosanoid signaling pathway 61
          eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma 0
          leukotriene signaling pathway 0
          prostanoid signaling pathway + 8
Path 2
Term Annotations click to browse term
  pathway 3928
    signaling pathway 1887
      hormone signaling pathway 368
        lipid hormone signaling pathway 111
          eicosanoid signaling pathway 61
            eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma 0
            leukotriene signaling pathway 0
            prostanoid signaling pathway + 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.