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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:androgen signaling pathway
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Accession:PW:0000564 term browser browse the term
Definition:Androgens are C19 steroids that constitutes the male sex hormones. They are also the precursors of female sex hormones, the estrogens. Testosterone and its more potent metabolite, dihydrotestosterone bind to androgen receptors to then translocate to the nucleus and activate the transcription of target genes. Many regulators, both activators and repressors, have been identified. Upregulation of receptor activity has been implicated in prostate cancer.
Synonyms:related_synonym: PID:200105
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androgen signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor ISO RGD PMID:16356826 RGD:2326084 NCBI chr24:34,713,390...34,731,461
NCBI chr  X:51,969,785...52,167,450
Ensembl chr  X:51,969,785...52,151,912 		JBrowse link
G CARM1 coactivator associated arginine methyltransferase 1 ISO RGD PMID:17163421 RGD:2326123 NCBI chr20:50,328,466...50,371,845
Ensembl chr20:50,331,030...50,348,195 		JBrowse link
G CREBBP CREB binding protein ISO RGD PMID:17163421 RGD:2326123 NCBI chr 6:37,410,201...37,536,688
Ensembl chr 6:37,409,930...37,534,176 		JBrowse link
G DNAJA2 DnaJ heat shock protein family (Hsp40) member A2 ISO RGD PMID:16356826 RGD:2326084 NCBI chr 2:67,903,292...67,916,267 JBrowse link
G EP300 E1A binding protein p300 ISO RGD PMID:17163421 RGD:2326123 NCBI chr10:24,076,538...24,156,708
Ensembl chr10:24,077,971...24,156,396 		JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 ISO RGD PMID:16356826 RGD:2326084 NCBI chr 8:70,091,203...70,096,107
Ensembl chr 8:70,092,217...70,095,243 		JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 ISO RGD PMID:16356826 RGD:2326084 NCBI chr12:12,658,415...12,664,945
Ensembl chr12:12,660,008...12,664,940 		JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 ISO RGD PMID:16356826 RGD:2326084 NCBI chr 5:11,292,219...11,296,851
Ensembl chr 5:11,292,262...11,296,797 		JBrowse link
G NCOA1 nuclear receptor coactivator 1 ISO RGD PMID:17163421 RGD:2326123 NCBI chr17:18,880,676...19,124,300
Ensembl chr17:18,880,383...19,122,258 		JBrowse link
G NCOA2 nuclear receptor coactivator 2 ISO RGD PMID:17163421 RGD:2326123 NCBI chr29:19,253,849...19,471,640
Ensembl chr29:19,222,842...19,545,371 		JBrowse link
G NCOA3 nuclear receptor coactivator 3 ISO RGD PMID:17163421 RGD:2326123 Ensembl chr24:34,585,305...34,728,674
Ensembl chr24:34,585,305...34,728,674 		JBrowse link
G NCOR1 nuclear receptor corepressor 1 ISO RGD PMID:17163421 RGD:2326123 NCBI chr 5:39,687,530...39,837,003
Ensembl chr 5:39,687,543...39,836,464 		JBrowse link
G NCOR2 nuclear receptor corepressor 2 ISO RGD PMID:17163421 RGD:2326123 NCBI chr26:5,352,670...5,493,741
Ensembl chr26:5,331,459...5,493,830 		JBrowse link
G PIAS2 protein inhibitor of activated STAT 2 ISO RGD PMID:9920921 RGD:70792 NCBI chr 7:44,436,100...44,583,657
Ensembl chr 7:44,454,095...44,583,657 		JBrowse link
G PRMT1 protein arginine methyltransferase 1 ISO RGD PMID:17163421 RGD:2326123 NCBI chr 1:106,849,864...106,859,896
Ensembl chr 1:106,849,864...106,874,075 		JBrowse link
G ST13 ST13 Hsp70 interacting protein ISO RGD PMID:16356826 RGD:2326084 NCBI chr10:24,379,997...24,411,764
Ensembl chr10:24,379,997...24,411,766 		JBrowse link
G STIP1 stress induced phosphoprotein 1 ISO RGD PMID:16356826 RGD:2326084 NCBI chr18:52,854,262...52,868,187
Ensembl chr18:52,854,663...52,868,478 		JBrowse link
altered androgen signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor ISO RGD PMID:18008377 PMID:23759327 RGD:2326139 RGD:8693397 NCBI chr24:34,713,390...34,731,461
NCBI chr  X:51,969,785...52,167,450
Ensembl chr  X:51,969,785...52,151,912 		JBrowse link
G NCOA2 nuclear receptor coactivator 2 ISO RGD PMID:23759327 RGD:8693397 NCBI chr29:19,253,849...19,471,640
Ensembl chr29:19,222,842...19,545,371 		JBrowse link
G NCOR2 nuclear receptor corepressor 2 ISO RGD PMID:23759327 RGD:8693397 NCBI chr26:5,352,670...5,493,741
Ensembl chr26:5,331,459...5,493,830 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4052
    signaling pathway 1939
      transcription factor mediated signaling pathway 376
        androgen signaling pathway 17
          altered androgen signaling pathway 3
Path 2
Term Annotations click to browse term
  pathway 4052
    signaling pathway 1939
      hormone signaling pathway 379
        lipid hormone signaling pathway 112
          steroid hormone signaling pathway 51
            sex steroids signaling pathway 34
              androgen signaling pathway 17
                altered androgen signaling pathway 3
paths to the root