PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: protein kinase A (PKA) signaling pathway
Accession: PW:0000543
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Definition: Protein kinase A (PKA) signaling is a widely used intracellular pathway and the major route for channeling the cAMP signal. cAMP is regulated by adenylyl cyclases that produce it and phosphodiesterases that hydrolyze it. Compartmentalization of PKA signaling is mediated by the AKAP family of scaffold proteins that bring together the kinase, cAMP modulators and sometimes the targets.
Synonyms: related_synonym: cAMP-dependent protein kinase A signaling pathway; cAMP/PKA signaling pathway; protein kinase A signaling
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Adcy1
adenylate cyclase 1
ISO
RGD
PMID:18948702
RGD:2312469
NCBI chr14:86,125,119...86,234,459
Ensembl chr14:81,911,099...82,028,969
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Adcy10
adenylate cyclase 10
ISO
RGD
PMID:18948702
RGD:2312469
NCBI chr13:80,280,595...80,366,939
Ensembl chr13:77,768,468...77,833,951
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Adcy2
adenylate cyclase 2
ISO
RGD
PMID:18948702
RGD:2312469
NCBI chr 1:36,204,054...36,650,645
Ensembl chr 1:34,375,895...34,822,236
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Adcy3
adenylate cyclase 3
ISO
RGD
PMID:18948702
RGD:2312469
NCBI chr 6:32,819,602...32,923,174
Ensembl chr 6:27,124,828...27,203,686
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Adcy4
adenylate cyclase 4
ISO
RGD
PMID:18948702
RGD:2312469
NCBI chr15:33,236,201...33,252,070
Ensembl chr15:29,266,287...29,282,108
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Adcy5
adenylate cyclase 5
ISO
RGD
PMID:18948702
RGD:2312469
NCBI chr11:78,976,861...79,123,343
Ensembl chr11:65,471,612...65,618,974
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Adcy6
adenylate cyclase 6
ISO IDA
RGD
PMID:18948702 PMID:15579502
RGD:2312469 , RGD:2313211
NCBI chr 7:131,621,860...131,642,923
Ensembl chr 7:129,742,838...129,763,754
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Adcy7
adenylate cyclase 7
ISO
RGD
PMID:18948702
RGD:2312469
NCBI chr19:34,913,154...34,972,366
Ensembl chr19:18,740,875...18,776,311
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Adcy8
adenylate cyclase 8
ISO
RGD
PMID:18948702
RGD:2312469
NCBI chr 7:98,306,434...98,555,687
Ensembl chr 7:96,417,324...96,665,911
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Adcy9
adenylate cyclase 9
ISO
RGD
PMID:18948702
RGD:2312469
NCBI chr10:11,645,373...11,768,462
Ensembl chr10:11,139,446...11,262,066
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Akap1
A-kinase anchoring protein 1
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr10:74,118,232...74,151,366
Ensembl chr10:73,621,883...73,653,896
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Akap10
A-kinase anchoring protein 10
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr10:47,044,819...47,108,153
Ensembl chr10:46,551,532...46,608,769
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Akap11
A-kinase anchoring protein 11
ISO IMP
RGD
PMID:14715913 PMID:19319965 PMID:18385542
RGD:2312475 , RGD:2312477 , RGD:2312637
NCBI chr15:60,320,839...60,365,480
Ensembl chr15:53,911,657...53,941,605
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Akap12
A-kinase anchoring protein 12
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr 1:43,135,515...43,225,245
Ensembl chr 1:40,730,123...40,819,886
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Akap13
A-kinase anchoring protein 13
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr 1:138,722,445...139,029,401
Ensembl chr 1:129,314,402...129,619,646
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Akap14
A-kinase anchoring protein 14
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr X:116,395,512...116,410,697
Ensembl chr X:116,395,516...116,410,697
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Akap3
A-kinase anchoring protein 3
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr 4:161,374,198...161,400,062
Ensembl chr 4:159,699,289...159,713,903
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Akap4
A-kinase anchoring protein 4
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr X:18,107,256...18,117,549
Ensembl chr X:15,435,410...15,445,684
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Akap5
A-kinase anchoring protein 5
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr 6:100,787,169...100,796,712
Ensembl chr 6:95,051,537...95,061,578
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Akap6
A-kinase anchoring protein 6
ISO IMP
RGD
PMID:14715913 PMID:19319965 PMID:11296225
RGD:2312475 , RGD:2312477 , RGD:68716
NCBI chr 6:75,919,350...76,359,667
Ensembl chr 6:70,184,175...70,619,738
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Akap7
A-kinase anchoring protein 7
ISO IMP
RGD
PMID:14715913 PMID:19319965 PMID:17901878
RGD:2312475 , RGD:2312477 , RGD:2312630
NCBI chr 1:21,906,503...22,168,663
Ensembl chr 1:20,087,373...20,217,797
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Akap8
A-kinase anchoring protein 8
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr 7:11,966,769...11,983,056
Ensembl chr 7:11,316,228...11,332,399
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Akap9
A-kinase anchoring protein 9
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr 4:31,011,475...31,147,338
Ensembl chr 4:30,056,738...30,192,606
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Crhr2
corticotropin releasing hormone receptor 2
IMP
RGD
PMID:15911134
RGD:5131271
NCBI chr 4:85,553,163...85,596,203
Ensembl chr 4:84,224,002...84,265,904
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Ezr
ezrin
ISO
RGD
PMID:14715913
RGD:2312475
NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:46,967,658...47,011,505
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Glp1r
glucagon-like peptide 1 receptor
IMP
RGD
PMID:10446905
RGD:1598448
NCBI chr20:8,973,393...9,011,622
Ensembl chr20:8,972,004...9,010,241
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Pakap
paralemmin A kinase anchor protein
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr 5:76,976,906...77,443,656
Ensembl chr 5:72,181,718...72,648,524
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Pde10a
phosphodiesterase 10A
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 1:54,313,343...54,765,668
Ensembl chr 1:51,770,132...52,216,563
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Pde11a
phosphodiesterase 11A
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 3:81,320,822...81,704,397
Ensembl chr 3:60,913,562...61,297,158
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Pde1a
phosphodiesterase 1A
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 3:85,152,053...85,432,289
Ensembl chr 3:64,747,269...65,024,874
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Pde1b
phosphodiesterase 1B
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 7:136,505,834...136,533,034
Ensembl chr 7:134,627,322...134,654,580
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Pde1c
phosphodiesterase 1C
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 4:86,629,074...87,108,147
Ensembl chr 4:85,300,858...85,863,219
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Pde2a
phosphodiesterase 2A
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 1:165,235,623...165,327,466
Ensembl chr 1:155,813,180...155,915,434
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Pde3a
phosphodiesterase 3A
ISO
RGD
PMID:17376027 PMID:17376027
RGD:2312479 , RGD:2312479
NCBI chr 4:175,904,276...176,170,531
Ensembl chr 4:174,172,868...174,438,274
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Pde3b
phosphodiesterase 3B
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 1:178,041,207...178,204,503
Ensembl chr 1:168,607,022...168,769,334
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Pde4a
phosphodiesterase 4A
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 8:27,966,978...28,029,721
Ensembl chr 8:19,703,290...19,751,961
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Pde4b
phosphodiesterase 4B
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:116,799,971...117,367,696
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Pde4c
phosphodiesterase 4C
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr16:18,724,703...18,745,528
Ensembl chr16:18,691,700...18,710,640
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Pde4d
phosphodiesterase 4D
ISO IMP
RGD
PMID:17376027 PMID:11296225
RGD:2312479 , RGD:68716
NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:40,019,933...41,525,884
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Pde7a
phosphodiesterase 7A
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 2:103,631,655...103,723,057
Ensembl chr 2:101,718,444...101,806,681
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Pde7b
phosphodiesterase 7B
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 1:16,994,072...17,312,828
Ensembl chr 1:15,182,704...15,492,900
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Pde8a
phosphodiesterase 8A
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 1:144,575,203...144,698,216
Ensembl chr 1:135,166,237...135,288,024
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Pde8b
phosphodiesterase 8B
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 2:28,009,841...28,244,050
Ensembl chr 2:26,276,635...26,509,209
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Prkaca
protein kinase cAMP-activated catalytic subunit alpha
ISO
RGD
PMID:14715913
RGD:2312475
NCBI chr19:41,059,843...41,083,189
Ensembl chr19:24,155,090...24,178,430
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Prkacb
protein kinase cAMP-activated catalytic subunit beta
ISO
RGD
PMID:14715913
RGD:2312475
NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:235,636,885...235,726,198
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Prkar1a
protein kinase cAMP-dependent type I regulatory subunit alpha
ISO
RGD
PMID:14715913
RGD:2312475
NCBI chr10:95,120,537...95,139,028
Ensembl chr10:94,620,039...94,639,041
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Prkar1b
protein kinase cAMP-dependent type I regulatory subunit beta
ISO
RGD
PMID:14715913
RGD:2312475
NCBI chr12:20,606,066...20,738,766
Ensembl chr12:15,511,801...15,624,942
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Prkar2a
protein kinase cAMP-dependent type II regulatory subunit alpha
ISO
RGD
PMID:14715913
RGD:2312475
NCBI chr 8:118,271,608...118,337,332
Ensembl chr 8:109,395,833...109,455,628
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Prkar2b
protein kinase cAMP-dependent type II regulatory subunit beta
ISO
RGD
PMID:14715913
RGD:2312475
NCBI chr 6:54,291,143...54,381,639
Ensembl chr 6:48,563,662...48,653,933
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