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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:protein kinase A (PKA) signaling pathway
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Accession:PW:0000543 term browser browse the term
Definition:Protein kinase A (PKA) signaling is a widely used intracellular pathway and the major route for channeling the cAMP signal. cAMP is regulated by adenylyl cyclases that produce it and phosphodiesterases that hydrolyze it. Compartmentalization of PKA signaling is mediated by the AKAP family of scaffold proteins that bring together the kinase, cAMP modulators and sometimes the targets.
Synonyms:related_synonym: cAMP-dependent protein kinase A signaling pathway;   cAMP/PKA signaling pathway;   protein kinase A signaling

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protein kinase A (PKA) signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy1 adenylate cyclase 1 TAS RGD PMID:18948702 RGD:2312469 NCBI chr11:7,013,433...7,128,506
Ensembl chr11:7,013,489...7,128,506
JBrowse link
G Adcy10 adenylate cyclase 10 TAS RGD PMID:18948702 RGD:2312469 NCBI chr 1:165,309,114...165,404,347
Ensembl chr 1:165,312,752...165,404,343
JBrowse link
G Adcy2 adenylate cyclase 2 ISO RGD PMID:18948702 RGD:2312469 NCBI chr13:68,768,162...69,147,719
Ensembl chr13:68,768,162...69,147,660
JBrowse link
G Adcy3 adenylate cyclase 3 TAS RGD PMID:18948702 RGD:2312469 NCBI chr12:4,183,397...4,263,525
Ensembl chr12:4,183,103...4,263,525
JBrowse link
G Adcy4 adenylate cyclase 4 ISO RGD PMID:18948702 RGD:2312469 NCBI chr14:56,006,513...56,021,552
Ensembl chr14:56,006,514...56,021,552
JBrowse link
G Adcy5 adenylate cyclase 5 TAS RGD PMID:18948702 RGD:2312469 NCBI chr16:34,974,933...35,126,108
Ensembl chr16:34,975,247...35,126,108
JBrowse link
G Adcy6 adenylate cyclase 6 TAS
ISO
RGD PMID:18948702 PMID:15579502 RGD:2312469, RGD:2313211 NCBI chr15:98,484,982...98,508,119
Ensembl chr15:98,487,854...98,507,957
JBrowse link
G Adcy7 adenylate cyclase 7 ISO RGD PMID:18948702 RGD:2312469 NCBI chr 8:88,998,818...89,056,593
Ensembl chr 8:88,999,031...89,056,590
JBrowse link
G Adcy8 adenylate cyclase 8 TAS RGD PMID:18948702 RGD:2312469 NCBI chr15:64,570,884...64,794,145
Ensembl chr15:64,568,933...64,794,145
JBrowse link
G Adcy9 adenylate cyclase 9 TAS RGD PMID:18948702 RGD:2312469 NCBI chr16:4,102,750...4,255,094
Ensembl chr16:4,105,393...4,238,362
JBrowse link
G Akap1 A kinase anchor protein 1 ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr11:88,721,618...88,755,426
Ensembl chr11:88,721,618...88,755,412
JBrowse link
G Akap10 A kinase anchor protein 10 ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr11:61,756,029...61,821,134
Ensembl chr11:61,762,133...61,821,078
JBrowse link
G Akap11 A kinase anchor protein 11 ISO RGD PMID:14715913 PMID:19319965 PMID:18385542 RGD:2312475, RGD:2312477, RGD:2312637 NCBI chr14:78,729,686...78,774,306
Ensembl chr14:78,729,686...78,774,248
JBrowse link
G Akap12 A kinase anchor protein 12 ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr10:4,216,329...4,309,471
Ensembl chr10:4,216,380...4,309,470
JBrowse link
G Akap13 A kinase anchor protein 13 ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr 7:75,105,271...75,404,357
Ensembl chr 7:75,105,282...75,404,357
JBrowse link
G Akap14 A kinase anchor protein 14 ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr  X:36,414,351...36,432,495
Ensembl chr  X:36,414,351...36,432,495
JBrowse link
G Akap3 A kinase anchor protein 3 ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr 6:126,830,061...126,851,271
Ensembl chr 6:126,830,061...126,851,271
JBrowse link
G Akap4 A kinase anchor protein 4 ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr  X:6,933,754...6,944,848
Ensembl chr  X:6,933,758...6,944,848
JBrowse link
G Akap5 A kinase anchor protein 5 ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr12:76,371,652...76,380,925
Ensembl chr12:76,371,665...76,380,927
JBrowse link
G Akap6 A kinase anchor protein 6 ISO RGD PMID:14715913 PMID:19319965 PMID:11296225 RGD:2312475, RGD:2312477, RGD:68716 NCBI chr12:52,745,371...53,202,351
Ensembl chr12:52,746,166...53,202,382
JBrowse link
G Akap7 A kinase anchor protein 7 ISO RGD PMID:14715913 PMID:19319965 PMID:17901878 RGD:2312475, RGD:2312477, RGD:2312630 NCBI chr10:25,044,988...25,175,115
Ensembl chr10:25,044,988...25,183,768
JBrowse link
G Akap8 A kinase anchor protein 8 ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr17:32,522,646...32,540,212
Ensembl chr17:32,522,646...32,540,212
JBrowse link
G Akap9 A kinase anchor protein 9 ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr 5:3,977,410...4,130,204
Ensembl chr 5:3,978,054...4,131,310
JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 ISO RGD PMID:15911134 RGD:5131271 NCBI chr 6:55,067,033...55,110,001
Ensembl chr 6:55,067,034...55,110,001
JBrowse link
G Ezr ezrin ISO RGD PMID:14715913 RGD:2312475 NCBI chr17:7,005,530...7,050,179
Ensembl chr17:7,005,440...7,050,183
JBrowse link
G Glp1r glucagon-like peptide 1 receptor ISO RGD PMID:10446905 RGD:1598448 NCBI chr17:31,120,841...31,155,484
Ensembl chr17:31,120,791...31,159,765
JBrowse link
G Pakap paralemmin A kinase anchor protein ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr 4:57,434,475...57,896,984
Ensembl chr 4:57,717,657...57,896,984
Ensembl chr 4:57,717,657...57,896,984
Ensembl chr 4:57,717,657...57,896,984
JBrowse link
G Pde10a phosphodiesterase 10A ISO RGD PMID:17376027 RGD:2312479 NCBI chr17:8,742,719...9,205,480
Ensembl chr17:8,744,204...9,205,480
JBrowse link
G Pde11a phosphodiesterase 11A ISO RGD PMID:17376027 RGD:2312479 NCBI chr 2:75,816,152...76,169,501
Ensembl chr 2:75,819,485...76,169,118
JBrowse link
G Pde1a phosphodiesterase 1A, calmodulin-dependent ISO RGD PMID:17376027 RGD:2312479 NCBI chr 2:79,664,797...80,026,862
Ensembl chr 2:79,664,797...79,959,802
JBrowse link
G Pde1b phosphodiesterase 1B, Ca2+-calmodulin dependent ISO RGD PMID:17376027 RGD:2312479 NCBI chr15:103,411,461...103,438,483
Ensembl chr15:103,411,461...103,438,479
JBrowse link
G Pde1c phosphodiesterase 1C ISO RGD PMID:17376027 RGD:2312479 NCBI chr 6:56,046,783...56,629,590
Ensembl chr 6:56,046,789...56,629,472
JBrowse link
G Pde2a phosphodiesterase 2A, cGMP-stimulated ISO RGD PMID:17376027 RGD:2312479 NCBI chr 7:101,070,905...101,162,026
Ensembl chr 7:101,060,093...101,162,026
Ensembl chr 7:101,060,093...101,162,026
JBrowse link
G Pde3a phosphodiesterase 3A, cGMP inhibited ISO RGD PMID:17376027 RGD:2312479 NCBI chr 6:141,194,995...141,452,588
Ensembl chr 6:141,194,995...141,453,174
JBrowse link
G Pde3b phosphodiesterase 3B, cGMP-inhibited ISO RGD PMID:17376027 RGD:2312479 NCBI chr 7:114,014,388...114,137,173
Ensembl chr 7:114,014,516...114,138,486
JBrowse link
G Pde4a phosphodiesterase 4A, cAMP specific ISO RGD PMID:17376027 RGD:2312479 NCBI chr 9:21,076,998...21,124,544
Ensembl chr 9:21,073,005...21,124,544
JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific ISO RGD PMID:17376027 RGD:2312479 NCBI chr 4:101,944,529...102,464,459
Ensembl chr 4:101,944,740...102,464,456
JBrowse link
G Pde4c phosphodiesterase 4C, cAMP specific ISO RGD PMID:17376027 RGD:2312479 NCBI chr 8:71,176,485...71,203,835
Ensembl chr 8:71,176,369...71,203,835
JBrowse link
G Pde4d phosphodiesterase 4D, cAMP specific ISO RGD PMID:17376027 PMID:11296225 RGD:2312479, RGD:68716 NCBI chr13:108,790,711...110,092,503
Ensembl chr13:108,586,482...110,089,995
JBrowse link
G Pde7a phosphodiesterase 7A ISO RGD PMID:17376027 RGD:2312479 NCBI chr 3:19,277,272...19,365,486
Ensembl chr 3:19,277,272...19,365,486
JBrowse link
G Pde7b phosphodiesterase 7B ISO RGD PMID:17376027 RGD:2312479 NCBI chr10:20,272,798...20,600,824
Ensembl chr10:20,273,750...20,600,824
JBrowse link
G Pde8a phosphodiesterase 8A ISO RGD PMID:17376027 RGD:2312479 NCBI chr 7:80,863,013...80,984,283
Ensembl chr 7:80,863,344...80,984,281
JBrowse link
G Pde8b phosphodiesterase 8B ISO RGD PMID:17376027 RGD:2312479 NCBI chr13:95,160,962...95,386,904
Ensembl chr13:95,160,962...95,386,844
JBrowse link
G Prkaca protein kinase, cAMP dependent, catalytic, alpha ISO RGD PMID:14715913 RGD:2312475 NCBI chr 8:84,699,607...84,723,073
Ensembl chr 8:84,699,622...84,723,072
JBrowse link
G Prkacb protein kinase, cAMP dependent, catalytic, beta ISO RGD PMID:14715913 RGD:2312475 NCBI chr 3:146,435,334...146,518,691
Ensembl chr 3:146,435,329...146,518,745
JBrowse link
G Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha ISO RGD PMID:14715913 RGD:2312475 NCBI chr11:109,539,849...109,560,489
Ensembl chr11:109,540,231...109,560,482
JBrowse link
G Prkar1b protein kinase, cAMP dependent regulatory, type I beta ISO RGD PMID:14715913 RGD:2312475 NCBI chr 5:139,003,059...139,136,458
Ensembl chr 5:139,003,061...139,135,756
JBrowse link
G Prkar2a protein kinase, cAMP dependent regulatory, type II alpha ISO RGD PMID:14715913 RGD:2312475 NCBI chr 9:108,569,342...108,627,643
Ensembl chr 9:108,566,513...108,627,635
JBrowse link
G Prkar2b protein kinase, cAMP dependent regulatory, type II beta ISO RGD PMID:14715913 RGD:2312475 NCBI chr12:32,008,468...32,111,639
Ensembl chr12:32,008,475...32,111,295
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6074
    signaling pathway 2500
      signaling pathway involving second messengers 365
        protein kinase A (PKA) signaling pathway 49
Path 2
Term Annotations click to browse term
  pathway 6074
    signaling pathway 2500
      kinase mediated signaling pathway 618
        serine/threonine-specific kinase mediated signaling pathway 478
          protein kinase A (PKA) signaling pathway 49
paths to the root