PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: protein kinase A (PKA) signaling pathway
Accession: PW:0000543
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Definition: Protein kinase A (PKA) signaling is a widely used intracellular pathway and the major route for channeling the cAMP signal. cAMP is regulated by adenylyl cyclases that produce it and phosphodiesterases that hydrolyze it. Compartmentalization of PKA signaling is mediated by the AKAP family of scaffold proteins that bring together the kinase, cAMP modulators and sometimes the targets.
Synonyms: related_synonym: cAMP-dependent protein kinase A signaling pathway; cAMP/PKA signaling pathway; protein kinase A signaling
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Adcy1
adenylate cyclase 1
TAS
RGD
PMID:18948702
RGD:2312469
NCBI chr11:7,013,433...7,128,506
Ensembl chr11:7,013,489...7,128,506
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Adcy10
adenylate cyclase 10
TAS
RGD
PMID:18948702
RGD:2312469
NCBI chr 1:165,309,114...165,404,347
Ensembl chr 1:165,312,752...165,404,343
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Adcy2
adenylate cyclase 2
ISO
RGD
PMID:18948702
RGD:2312469
NCBI chr13:68,768,162...69,147,719
Ensembl chr13:68,768,162...69,147,660
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Adcy3
adenylate cyclase 3
TAS
RGD
PMID:18948702
RGD:2312469
NCBI chr12:4,183,397...4,263,525
Ensembl chr12:4,183,103...4,263,525
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Adcy4
adenylate cyclase 4
ISO
RGD
PMID:18948702
RGD:2312469
NCBI chr14:56,006,513...56,021,552
Ensembl chr14:56,006,514...56,021,552
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Adcy5
adenylate cyclase 5
TAS
RGD
PMID:18948702
RGD:2312469
NCBI chr16:34,974,933...35,126,108
Ensembl chr16:34,975,247...35,126,108
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Adcy6
adenylate cyclase 6
TAS ISO
RGD
PMID:18948702 PMID:15579502
RGD:2312469 , RGD:2313211
NCBI chr15:98,484,982...98,508,119
Ensembl chr15:98,487,854...98,507,957
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Adcy7
adenylate cyclase 7
ISO
RGD
PMID:18948702
RGD:2312469
NCBI chr 8:88,998,818...89,056,593
Ensembl chr 8:88,999,031...89,056,590
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Adcy8
adenylate cyclase 8
TAS
RGD
PMID:18948702
RGD:2312469
NCBI chr15:64,570,884...64,794,145
Ensembl chr15:64,568,933...64,794,145
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Adcy9
adenylate cyclase 9
TAS
RGD
PMID:18948702
RGD:2312469
NCBI chr16:4,102,750...4,255,094
Ensembl chr16:4,105,393...4,238,362
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Akap1
A kinase anchor protein 1
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr11:88,721,618...88,755,426
Ensembl chr11:88,721,618...88,755,412
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Akap10
A kinase anchor protein 10
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr11:61,756,029...61,821,134
Ensembl chr11:61,762,133...61,821,078
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Akap11
A kinase anchor protein 11
ISO
RGD
PMID:14715913 PMID:19319965 PMID:18385542
RGD:2312475 , RGD:2312477 , RGD:2312637
NCBI chr14:78,729,686...78,774,306
Ensembl chr14:78,729,686...78,774,248
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Akap12
A kinase anchor protein 12
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr10:4,216,329...4,309,471
Ensembl chr10:4,216,380...4,309,470
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Akap13
A kinase anchor protein 13
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr 7:75,105,271...75,404,357
Ensembl chr 7:75,105,282...75,404,357
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Akap14
A kinase anchor protein 14
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr X:36,414,351...36,432,495
Ensembl chr X:36,414,351...36,432,495
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Akap3
A kinase anchor protein 3
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr 6:126,830,061...126,851,271
Ensembl chr 6:126,830,061...126,851,271
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Akap4
A kinase anchor protein 4
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr X:6,933,754...6,944,848
Ensembl chr X:6,933,758...6,944,848
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Akap5
A kinase anchor protein 5
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr12:76,371,652...76,380,925
Ensembl chr12:76,371,665...76,380,927
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Akap6
A kinase anchor protein 6
ISO
RGD
PMID:14715913 PMID:19319965 PMID:11296225
RGD:2312475 , RGD:2312477 , RGD:68716
NCBI chr12:52,745,371...53,202,351
Ensembl chr12:52,746,166...53,202,382
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Akap7
A kinase anchor protein 7
ISO
RGD
PMID:14715913 PMID:19319965 PMID:17901878
RGD:2312475 , RGD:2312477 , RGD:2312630
NCBI chr10:25,044,988...25,175,115
Ensembl chr10:25,044,988...25,183,768
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Akap8
A kinase anchor protein 8
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr17:32,522,646...32,540,212
Ensembl chr17:32,522,646...32,540,212
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Akap9
A kinase anchor protein 9
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr 5:3,977,410...4,130,204
Ensembl chr 5:3,978,054...4,131,310
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Crhr2
corticotropin releasing hormone receptor 2
ISO
RGD
PMID:15911134
RGD:5131271
NCBI chr 6:55,067,033...55,110,001
Ensembl chr 6:55,067,034...55,110,001
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Ezr
ezrin
ISO
RGD
PMID:14715913
RGD:2312475
NCBI chr17:7,005,530...7,050,179
Ensembl chr17:7,005,440...7,050,183
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Glp1r
glucagon-like peptide 1 receptor
ISO
RGD
PMID:10446905
RGD:1598448
NCBI chr17:31,120,841...31,155,484
Ensembl chr17:31,120,791...31,159,765
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Pakap
paralemmin A kinase anchor protein
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr 4:57,434,475...57,896,984
Ensembl chr 4:57,717,657...57,896,984 Ensembl chr 4:57,717,657...57,896,984 Ensembl chr 4:57,717,657...57,896,984
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Pde10a
phosphodiesterase 10A
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr17:8,742,719...9,205,480
Ensembl chr17:8,744,204...9,205,480
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Pde11a
phosphodiesterase 11A
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 2:75,816,152...76,169,501
Ensembl chr 2:75,819,485...76,169,118
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Pde1a
phosphodiesterase 1A, calmodulin-dependent
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 2:79,664,797...80,026,862
Ensembl chr 2:79,664,797...79,959,802
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Pde1b
phosphodiesterase 1B, Ca2+-calmodulin dependent
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr15:103,411,461...103,438,483
Ensembl chr15:103,411,461...103,438,479
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Pde1c
phosphodiesterase 1C
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 6:56,046,783...56,629,590
Ensembl chr 6:56,046,789...56,629,472
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Pde2a
phosphodiesterase 2A, cGMP-stimulated
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 7:101,070,905...101,162,026
Ensembl chr 7:101,060,093...101,162,026 Ensembl chr 7:101,060,093...101,162,026
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Pde3a
phosphodiesterase 3A, cGMP inhibited
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 6:141,194,995...141,452,588
Ensembl chr 6:141,194,995...141,453,174
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Pde3b
phosphodiesterase 3B, cGMP-inhibited
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 7:114,014,388...114,137,173
Ensembl chr 7:114,014,516...114,138,486
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Pde4a
phosphodiesterase 4A, cAMP specific
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 9:21,076,998...21,124,544
Ensembl chr 9:21,073,005...21,124,544
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Pde4b
phosphodiesterase 4B, cAMP specific
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 4:101,944,529...102,464,459
Ensembl chr 4:101,944,740...102,464,456
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Pde4c
phosphodiesterase 4C, cAMP specific
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 8:71,176,485...71,203,835
Ensembl chr 8:71,176,369...71,203,835
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Pde4d
phosphodiesterase 4D, cAMP specific
ISO
RGD
PMID:17376027 PMID:11296225
RGD:2312479 , RGD:68716
NCBI chr13:108,790,711...110,092,503
Ensembl chr13:108,586,482...110,089,995
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Pde7a
phosphodiesterase 7A
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 3:19,277,272...19,365,486
Ensembl chr 3:19,277,272...19,365,486
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Pde7b
phosphodiesterase 7B
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr10:20,272,798...20,600,824
Ensembl chr10:20,273,750...20,600,824
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Pde8a
phosphodiesterase 8A
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 7:80,863,013...80,984,283
Ensembl chr 7:80,863,344...80,984,281
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Pde8b
phosphodiesterase 8B
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr13:95,160,962...95,386,904
Ensembl chr13:95,160,962...95,386,844
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Prkaca
protein kinase, cAMP dependent, catalytic, alpha
ISO
RGD
PMID:14715913
RGD:2312475
NCBI chr 8:84,699,607...84,723,073
Ensembl chr 8:84,699,622...84,723,072
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Prkacb
protein kinase, cAMP dependent, catalytic, beta
ISO
RGD
PMID:14715913
RGD:2312475
NCBI chr 3:146,435,334...146,518,691
Ensembl chr 3:146,435,329...146,518,745
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Prkar1a
protein kinase, cAMP dependent regulatory, type I, alpha
ISO
RGD
PMID:14715913
RGD:2312475
NCBI chr11:109,539,849...109,560,489
Ensembl chr11:109,540,231...109,560,482
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Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
ISO
RGD
PMID:14715913
RGD:2312475
NCBI chr 5:139,003,059...139,136,458
Ensembl chr 5:139,003,061...139,135,756
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Prkar2a
protein kinase, cAMP dependent regulatory, type II alpha
ISO
RGD
PMID:14715913
RGD:2312475
NCBI chr 9:108,569,342...108,627,643
Ensembl chr 9:108,566,513...108,627,635
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Prkar2b
protein kinase, cAMP dependent regulatory, type II beta
ISO
RGD
PMID:14715913
RGD:2312475
NCBI chr12:32,008,468...32,111,639
Ensembl chr12:32,008,475...32,111,295
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