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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:protein kinase A (PKA) signaling pathway
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Accession:PW:0000543 term browser browse the term
Definition:Protein kinase A (PKA) signaling is a widely used intracellular pathway and the major route for channeling the cAMP signal. cAMP is regulated by adenylyl cyclases that produce it and phosphodiesterases that hydrolyze it. Compartmentalization of PKA signaling is mediated by the AKAP family of scaffold proteins that bring together the kinase, cAMP modulators and sometimes the targets.
Synonyms:related_synonym: cAMP-dependent protein kinase A signaling pathway;   cAMP/PKA signaling pathway;   protein kinase A signaling

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protein kinase A (PKA) signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY1 adenylate cyclase 1 TAS RGD PMID:18948702 RGD:2312469 NCBI chr 7:45,574,140...45,723,116
Ensembl chr 7:45,574,140...45,723,116
JBrowse link
G ADCY10 adenylate cyclase 10 TAS RGD PMID:18948702 RGD:2312469 NCBI chr 1:167,809,386...167,914,134
Ensembl chr 1:167,809,386...167,914,215
JBrowse link
G ADCY2 adenylate cyclase 2 TAS RGD PMID:18948702 RGD:2312469 NCBI chr 5:7,396,138...7,830,081
Ensembl chr 5:7,396,138...7,830,081
JBrowse link
G ADCY3 adenylate cyclase 3 TAS RGD PMID:18948702 RGD:2312469 NCBI chr 2:24,819,169...24,920,237
Ensembl chr 2:24,819,169...24,920,237
JBrowse link
G ADCY4 adenylate cyclase 4 TAS RGD PMID:18948702 RGD:2312469 NCBI chr14:24,318,359...24,335,071
Ensembl chr14:24,318,349...24,335,093
JBrowse link
G ADCY5 adenylate cyclase 5 TAS RGD PMID:18948702 RGD:2312469 NCBI chr 3:123,282,296...123,449,090
Ensembl chr 3:123,282,296...123,449,090
JBrowse link
G ADCY6 adenylate cyclase 6 TAS
ISO
RGD PMID:18948702 PMID:15579502 RGD:2312469, RGD:2313211 NCBI chr12:48,766,194...48,789,974
Ensembl chr12:48,766,194...48,789,089
JBrowse link
G ADCY7 adenylate cyclase 7 TAS RGD PMID:18948702 RGD:2312469 NCBI chr16:50,244,699...50,318,135
Ensembl chr16:50,246,137...50,318,135
JBrowse link
G ADCY8 adenylate cyclase 8 TAS RGD PMID:18948702 RGD:2312469 NCBI chr 8:130,780,301...131,040,909
Ensembl chr 8:130,780,301...131,040,909
JBrowse link
G ADCY9 adenylate cyclase 9 TAS RGD PMID:18948702 RGD:2312469 NCBI chr16:3,953,387...4,116,442
Ensembl chr16:3,953,387...4,116,442
JBrowse link
G AKAP1 A-kinase anchoring protein 1 TAS RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr17:57,085,246...57,121,344
Ensembl chr17:57,085,092...57,121,346
JBrowse link
G AKAP10 A-kinase anchoring protein 10 TAS RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr17:19,904,302...19,977,828
Ensembl chr17:19,904,302...19,978,343
JBrowse link
G AKAP11 A-kinase anchoring protein 11 TAS
ISO
RGD PMID:14715913 PMID:19319965 PMID:18385542 RGD:2312475, RGD:2312477, RGD:2312637 NCBI chr13:42,271,477...42,323,261
Ensembl chr13:42,272,152...42,323,261
JBrowse link
G AKAP12 A-kinase anchoring protein 12 TAS RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr 6:151,239,967...151,358,559
Ensembl chr 6:151,239,967...151,358,559
JBrowse link
G AKAP13 A-kinase anchoring protein 13 TAS RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr15:85,380,603...85,749,358
Ensembl chr15:85,380,571...85,749,358
JBrowse link
G AKAP14 A-kinase anchoring protein 14 TAS RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr  X:119,895,893...119,920,716
Ensembl chr  X:119,895,837...119,920,716
JBrowse link
G AKAP3 A-kinase anchoring protein 3 TAS RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr12:4,615,518...4,649,051
Ensembl chr12:4,615,508...4,649,051
JBrowse link
G AKAP4 A-kinase anchoring protein 4 TAS RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr  X:50,190,777...50,201,007
Ensembl chr  X:50,190,777...50,201,007
JBrowse link
G AKAP5 A-kinase anchoring protein 5 TAS RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr14:64,465,499...64,474,503
Ensembl chr14:64,465,499...64,474,503
JBrowse link
G AKAP6 A-kinase anchoring protein 6 TAS
ISO
RGD PMID:14715913 PMID:19319965 PMID:11296225 RGD:2312475, RGD:2312477, RGD:68716 NCBI chr14:32,329,298...32,837,684
Ensembl chr14:32,329,298...32,837,684
JBrowse link
G AKAP7 A-kinase anchoring protein 7 TAS
ISO
RGD PMID:14715913 PMID:19319965 PMID:17901878 RGD:2312475, RGD:2312477, RGD:2312630 NCBI chr 6:131,125,627...131,283,532
Ensembl chr 6:131,135,467...131,283,535
JBrowse link
G AKAP8 A-kinase anchoring protein 8 TAS RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr19:15,353,385...15,379,787
Ensembl chr19:15,353,385...15,379,815
JBrowse link
G AKAP9 A-kinase anchoring protein 9 TAS RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr 7:91,940,862...92,110,673
Ensembl chr 7:91,940,840...92,110,673
JBrowse link
G CRHR2 corticotropin releasing hormone receptor 2 ISO RGD PMID:15911134 RGD:5131271 NCBI chr 7:30,651,942...30,700,103
Ensembl chr 7:30,651,942...30,700,129
JBrowse link
G EZR ezrin TAS RGD PMID:14715913 RGD:2312475 NCBI chr 6:158,765,748...158,819,368
Ensembl chr 6:158,765,741...158,819,368
JBrowse link
G GLP1R glucagon like peptide 1 receptor ISO RGD PMID:10446905 RGD:1598448 NCBI chr 6:39,048,781...39,091,303
Ensembl chr 6:39,048,781...39,091,303
JBrowse link
G PALM2AKAP2 PALM2 and AKAP2 fusion TAS RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr 9:109,640,787...110,172,512
Ensembl chr 9:109,498,325...110,172,512
JBrowse link
G PDE10A phosphodiesterase 10A TAS RGD PMID:17376027 RGD:2312479 NCBI chr 6:165,327,289...165,988,052
Ensembl chr 6:165,327,287...165,988,117
JBrowse link
G PDE11A phosphodiesterase 11A TAS RGD PMID:17376027 RGD:2312479 NCBI chr 2:177,623,244...178,108,339
Ensembl chr 2:177,623,244...178,108,339
JBrowse link
G PDE1A phosphodiesterase 1A TAS RGD PMID:17376027 RGD:2312479 NCBI chr 2:182,140,041...182,716,797
Ensembl chr 2:182,139,968...182,523,359
JBrowse link
G PDE1B phosphodiesterase 1B TAS RGD PMID:17376027 RGD:2312479 NCBI chr12:54,549,601...54,579,239
Ensembl chr12:54,549,601...54,579,239
JBrowse link
G PDE1C phosphodiesterase 1C TAS RGD PMID:17376027 RGD:2312479 NCBI chr 7:31,616,777...32,428,224
Ensembl chr 7:31,751,179...32,428,131
JBrowse link
G PDE2A phosphodiesterase 2A TAS RGD PMID:17376027 RGD:2312479 NCBI chr11:72,576,141...72,674,422
Ensembl chr11:72,576,141...72,674,591
JBrowse link
G PDE3A phosphodiesterase 3A TAS RGD PMID:17376027 RGD:2312479 NCBI chr12:20,368,537...20,688,583
Ensembl chr12:20,368,537...20,688,583
JBrowse link
G PDE3B phosphodiesterase 3B TAS RGD PMID:17376027 RGD:2312479 NCBI chr11:14,643,804...14,899,321
Ensembl chr11:14,643,804...14,872,044
JBrowse link
G PDE4A phosphodiesterase 4A TAS RGD PMID:17376027 RGD:2312479 NCBI chr19:10,416,773...10,469,631
Ensembl chr19:10,416,773...10,469,630
JBrowse link
G PDE4B phosphodiesterase 4B TAS RGD PMID:17376027 RGD:2312479 NCBI chr 1:65,792,510...66,374,579
Ensembl chr 1:65,792,514...66,374,579
JBrowse link
G PDE4C phosphodiesterase 4C TAS RGD PMID:17376027 RGD:2312479 NCBI chr19:18,207,965...18,255,362
Ensembl chr19:18,207,965...18,248,200
Ensembl chr19:18,207,965...18,248,200
JBrowse link
G PDE4D phosphodiesterase 4D TAS
ISO
RGD PMID:17376027 PMID:11296225 RGD:2312479, RGD:68716 NCBI chr 5:58,969,038...60,522,128
Ensembl chr 5:58,969,038...60,522,120
JBrowse link
G PDE7A phosphodiesterase 7A TAS RGD PMID:17376027 RGD:2312479 NCBI chr 8:65,714,334...65,842,064
Ensembl chr 8:65,714,334...65,842,322
JBrowse link
G PDE7B phosphodiesterase 7B TAS RGD PMID:17376027 RGD:2312479 NCBI chr 6:135,851,701...136,195,574
Ensembl chr 6:135,851,701...136,195,574
JBrowse link
G PDE8A phosphodiesterase 8A TAS RGD PMID:17376027 RGD:2312479 NCBI chr15:84,980,467...85,139,142
Ensembl chr15:84,980,440...85,139,145
JBrowse link
G PDE8B phosphodiesterase 8B TAS RGD PMID:17376027 RGD:2312479 NCBI chr 5:77,086,715...77,428,256
Ensembl chr 5:77,210,449...77,428,256
Ensembl chr 5:77,210,449...77,428,256
JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha TAS RGD PMID:14715913 RGD:2312475 NCBI chr19:14,091,688...14,117,762
Ensembl chr19:14,091,688...14,118,084
JBrowse link
G PRKACB protein kinase cAMP-activated catalytic subunit beta TAS RGD PMID:14715913 RGD:2312475 NCBI chr 1:84,078,079...84,238,498
Ensembl chr 1:84,078,062...84,238,498
JBrowse link
G PRKACG protein kinase cAMP-activated catalytic subunit gamma TAS RGD PMID:14715913 RGD:2312475 NCBI chr 9:69,012,504...69,014,113
Ensembl chr 9:69,012,504...69,014,113
JBrowse link
G PRKAR1A protein kinase cAMP-dependent type I regulatory subunit alpha TAS RGD PMID:14715913 RGD:2312475 NCBI chr17:68,413,623...68,551,316
Ensembl chr17:68,511,780...68,551,319
JBrowse link
G PRKAR1B protein kinase cAMP-dependent type I regulatory subunit beta TAS RGD PMID:14715913 RGD:2312475 NCBI chr 7:549,197...728,934
Ensembl chr 7:549,197...727,650
JBrowse link
G PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha TAS RGD PMID:14715913 RGD:2312475 NCBI chr 3:48,744,591...48,847,874
Ensembl chr 3:48,744,597...48,847,874
JBrowse link
G PRKAR2B protein kinase cAMP-dependent type II regulatory subunit beta TAS RGD PMID:14715913 RGD:2312475 NCBI chr 7:107,044,705...107,161,811
Ensembl chr 7:107,044,705...107,161,811
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5957
    signaling pathway 2493
      signaling pathway involving second messengers 366
        protein kinase A (PKA) signaling pathway 50
Path 2
Term Annotations click to browse term
  pathway 5957
    signaling pathway 2493
      kinase mediated signaling pathway 620
        serine/threonine-specific kinase mediated signaling pathway 478
          protein kinase A (PKA) signaling pathway 50
paths to the root