PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: protein kinase A (PKA) signaling pathway
Accession: PW:0000543
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Definition: Protein kinase A (PKA) signaling is a widely used intracellular pathway and the major route for channeling the cAMP signal. cAMP is regulated by adenylyl cyclases that produce it and phosphodiesterases that hydrolyze it. Compartmentalization of PKA signaling is mediated by the AKAP family of scaffold proteins that bring together the kinase, cAMP modulators and sometimes the targets.
Synonyms: related_synonym: cAMP-dependent protein kinase A signaling pathway; cAMP/PKA signaling pathway; protein kinase A signaling
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ADCY1
adenylate cyclase 1
TAS
RGD
PMID:18948702
RGD:2312469
NCBI chr 7:45,574,140...45,723,116
Ensembl chr 7:45,574,140...45,723,116
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ADCY10
adenylate cyclase 10
TAS
RGD
PMID:18948702
RGD:2312469
NCBI chr 1:167,809,386...167,914,134
Ensembl chr 1:167,809,386...167,914,215
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ADCY2
adenylate cyclase 2
TAS
RGD
PMID:18948702
RGD:2312469
NCBI chr 5:7,396,138...7,830,081
Ensembl chr 5:7,396,138...7,830,081
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ADCY3
adenylate cyclase 3
TAS
RGD
PMID:18948702
RGD:2312469
NCBI chr 2:24,819,169...24,920,237
Ensembl chr 2:24,819,169...24,920,237
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ADCY4
adenylate cyclase 4
TAS
RGD
PMID:18948702
RGD:2312469
NCBI chr14:24,318,359...24,335,071
Ensembl chr14:24,318,349...24,335,093
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ADCY5
adenylate cyclase 5
TAS
RGD
PMID:18948702
RGD:2312469
NCBI chr 3:123,282,296...123,449,090
Ensembl chr 3:123,282,296...123,449,090
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ADCY6
adenylate cyclase 6
TAS ISO
RGD
PMID:18948702 PMID:15579502
RGD:2312469 , RGD:2313211
NCBI chr12:48,766,194...48,789,974
Ensembl chr12:48,766,194...48,789,089
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ADCY7
adenylate cyclase 7
TAS
RGD
PMID:18948702
RGD:2312469
NCBI chr16:50,244,699...50,318,135
Ensembl chr16:50,246,137...50,318,135
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ADCY8
adenylate cyclase 8
TAS
RGD
PMID:18948702
RGD:2312469
NCBI chr 8:130,780,301...131,040,909
Ensembl chr 8:130,780,301...131,040,909
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ADCY9
adenylate cyclase 9
TAS
RGD
PMID:18948702
RGD:2312469
NCBI chr16:3,953,387...4,116,442
Ensembl chr16:3,953,387...4,116,442
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AKAP1
A-kinase anchoring protein 1
TAS
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr17:57,085,246...57,121,344
Ensembl chr17:57,085,092...57,121,346
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AKAP10
A-kinase anchoring protein 10
TAS
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr17:19,904,302...19,977,828
Ensembl chr17:19,904,302...19,978,343
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AKAP11
A-kinase anchoring protein 11
TAS ISO
RGD
PMID:14715913 PMID:19319965 PMID:18385542
RGD:2312475 , RGD:2312477 , RGD:2312637
NCBI chr13:42,271,477...42,323,261
Ensembl chr13:42,272,152...42,323,261
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AKAP12
A-kinase anchoring protein 12
TAS
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr 6:151,239,967...151,358,559
Ensembl chr 6:151,239,967...151,358,559
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AKAP13
A-kinase anchoring protein 13
TAS
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr15:85,380,603...85,749,358
Ensembl chr15:85,380,571...85,749,358
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AKAP14
A-kinase anchoring protein 14
TAS
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr X:119,895,893...119,920,716
Ensembl chr X:119,895,837...119,920,716
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AKAP3
A-kinase anchoring protein 3
TAS
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr12:4,615,518...4,649,051
Ensembl chr12:4,615,508...4,649,051
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AKAP4
A-kinase anchoring protein 4
TAS
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr X:50,190,777...50,201,007
Ensembl chr X:50,190,777...50,201,007
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AKAP5
A-kinase anchoring protein 5
TAS
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr14:64,465,499...64,474,503
Ensembl chr14:64,465,499...64,474,503
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AKAP6
A-kinase anchoring protein 6
TAS ISO
RGD
PMID:14715913 PMID:19319965 PMID:11296225
RGD:2312475 , RGD:2312477 , RGD:68716
NCBI chr14:32,329,298...32,837,684
Ensembl chr14:32,329,298...32,837,684
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AKAP7
A-kinase anchoring protein 7
TAS ISO
RGD
PMID:14715913 PMID:19319965 PMID:17901878
RGD:2312475 , RGD:2312477 , RGD:2312630
NCBI chr 6:131,125,627...131,283,532
Ensembl chr 6:131,135,467...131,283,535
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AKAP8
A-kinase anchoring protein 8
TAS
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr19:15,353,385...15,379,787
Ensembl chr19:15,353,385...15,379,815
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AKAP9
A-kinase anchoring protein 9
TAS
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr 7:91,940,862...92,110,673
Ensembl chr 7:91,940,840...92,110,673
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CRHR2
corticotropin releasing hormone receptor 2
ISO
RGD
PMID:15911134
RGD:5131271
NCBI chr 7:30,651,942...30,700,103
Ensembl chr 7:30,651,942...30,700,129
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EZR
ezrin
TAS
RGD
PMID:14715913
RGD:2312475
NCBI chr 6:158,765,748...158,819,368
Ensembl chr 6:158,765,741...158,819,368
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GLP1R
glucagon like peptide 1 receptor
ISO
RGD
PMID:10446905
RGD:1598448
NCBI chr 6:39,048,781...39,091,303
Ensembl chr 6:39,048,781...39,091,303
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PALM2AKAP2
PALM2 and AKAP2 fusion
TAS
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr 9:109,640,787...110,172,512
Ensembl chr 9:109,498,325...110,172,512
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PDE10A
phosphodiesterase 10A
TAS
RGD
PMID:17376027
RGD:2312479
NCBI chr 6:165,327,289...165,988,052
Ensembl chr 6:165,327,287...165,988,117
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PDE11A
phosphodiesterase 11A
TAS
RGD
PMID:17376027
RGD:2312479
NCBI chr 2:177,623,244...178,108,339
Ensembl chr 2:177,623,244...178,108,339
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PDE1A
phosphodiesterase 1A
TAS
RGD
PMID:17376027
RGD:2312479
NCBI chr 2:182,140,041...182,716,797
Ensembl chr 2:182,139,968...182,523,359
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PDE1B
phosphodiesterase 1B
TAS
RGD
PMID:17376027
RGD:2312479
NCBI chr12:54,549,601...54,579,239
Ensembl chr12:54,549,601...54,579,239
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PDE1C
phosphodiesterase 1C
TAS
RGD
PMID:17376027
RGD:2312479
NCBI chr 7:31,616,777...32,428,224
Ensembl chr 7:31,751,179...32,428,131
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PDE2A
phosphodiesterase 2A
TAS
RGD
PMID:17376027
RGD:2312479
NCBI chr11:72,576,141...72,674,422
Ensembl chr11:72,576,141...72,674,591
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PDE3A
phosphodiesterase 3A
TAS
RGD
PMID:17376027
RGD:2312479
NCBI chr12:20,368,537...20,688,583
Ensembl chr12:20,368,537...20,688,583
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PDE3B
phosphodiesterase 3B
TAS
RGD
PMID:17376027
RGD:2312479
NCBI chr11:14,643,804...14,899,321
Ensembl chr11:14,643,804...14,872,044
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PDE4A
phosphodiesterase 4A
TAS
RGD
PMID:17376027
RGD:2312479
NCBI chr19:10,416,773...10,469,631
Ensembl chr19:10,416,773...10,469,630
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PDE4B
phosphodiesterase 4B
TAS
RGD
PMID:17376027
RGD:2312479
NCBI chr 1:65,792,510...66,374,579
Ensembl chr 1:65,792,514...66,374,579
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PDE4C
phosphodiesterase 4C
TAS
RGD
PMID:17376027
RGD:2312479
NCBI chr19:18,207,965...18,255,362
Ensembl chr19:18,207,965...18,248,200 Ensembl chr19:18,207,965...18,248,200
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PDE4D
phosphodiesterase 4D
TAS ISO
RGD
PMID:17376027 PMID:11296225
RGD:2312479 , RGD:68716
NCBI chr 5:58,969,038...60,522,128
Ensembl chr 5:58,969,038...60,522,120
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PDE7A
phosphodiesterase 7A
TAS
RGD
PMID:17376027
RGD:2312479
NCBI chr 8:65,714,334...65,842,064
Ensembl chr 8:65,714,334...65,842,322
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PDE7B
phosphodiesterase 7B
TAS
RGD
PMID:17376027
RGD:2312479
NCBI chr 6:135,851,701...136,195,574
Ensembl chr 6:135,851,701...136,195,574
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PDE8A
phosphodiesterase 8A
TAS
RGD
PMID:17376027
RGD:2312479
NCBI chr15:84,980,467...85,139,142
Ensembl chr15:84,980,440...85,139,145
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PDE8B
phosphodiesterase 8B
TAS
RGD
PMID:17376027
RGD:2312479
NCBI chr 5:77,086,715...77,428,256
Ensembl chr 5:77,210,449...77,428,256 Ensembl chr 5:77,210,449...77,428,256
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PRKACA
protein kinase cAMP-activated catalytic subunit alpha
TAS
RGD
PMID:14715913
RGD:2312475
NCBI chr19:14,091,688...14,117,762
Ensembl chr19:14,091,688...14,118,084
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PRKACB
protein kinase cAMP-activated catalytic subunit beta
TAS
RGD
PMID:14715913
RGD:2312475
NCBI chr 1:84,078,079...84,238,498
Ensembl chr 1:84,078,062...84,238,498
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PRKACG
protein kinase cAMP-activated catalytic subunit gamma
TAS
RGD
PMID:14715913
RGD:2312475
NCBI chr 9:69,012,504...69,014,113
Ensembl chr 9:69,012,504...69,014,113
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PRKAR1A
protein kinase cAMP-dependent type I regulatory subunit alpha
TAS
RGD
PMID:14715913
RGD:2312475
NCBI chr17:68,413,623...68,551,316
Ensembl chr17:68,511,780...68,551,319
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PRKAR1B
protein kinase cAMP-dependent type I regulatory subunit beta
TAS
RGD
PMID:14715913
RGD:2312475
NCBI chr 7:549,197...728,934
Ensembl chr 7:549,197...727,650
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PRKAR2A
protein kinase cAMP-dependent type II regulatory subunit alpha
TAS
RGD
PMID:14715913
RGD:2312475
NCBI chr 3:48,744,591...48,847,874
Ensembl chr 3:48,744,597...48,847,874
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PRKAR2B
protein kinase cAMP-dependent type II regulatory subunit beta
TAS
RGD
PMID:14715913
RGD:2312475
NCBI chr 7:107,044,705...107,161,811
Ensembl chr 7:107,044,705...107,161,811
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