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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:adenosine monophosphate-activated protein kinase (AMPK) signaling pathway
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Accession:PW:0000542 term browser browse the term
Definition:AMPK senses changes in cellular energy as an ATP/AMP ratio. AMP binding allosterically activates AMPK; subsequent phosphorylation events lead to repression of energy consuming pathways. One target of AMPK is the mTOR signaling pathway. AMPK activates the inhibitory Tsc2 while inhibiting the mTorc1 complex.
Synonyms:related_synonym: 5'AMP-activated protein kinase;   AMPK signaling pathway
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adenosine monophosphate-activated protein kinase (AMPK) signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAB39 calcium binding protein 39 ISO RGD PMID:14511394 PMID:15509864 RGD:1600678 RGD:1600691 NCBI chr2B:117,965,688...118,074,063
Ensembl chr2B:236,809,549...236,870,646 		JBrowse link
G CALM1 calmodulin 1 ISO RGD PMID:16054095 RGD:2311420 NCBI chr14:71,015,099...71,026,322
Ensembl chr19:52,121,687...52,131,135 		JBrowse link
G CALM2 calmodulin 2 ISO RGD PMID:16054095 RGD:2311420 NCBI chr2A:47,274,722...47,290,861
Ensembl chr2A:48,204,518...48,220,697 		JBrowse link
G CALM3 calmodulin 3 ISO RGD PMID:16054095 RGD:2311420 NCBI chr19:43,593,069...43,602,550
Ensembl chr19:52,121,687...52,131,135 		JBrowse link
G CAMKK1 calcium/calmodulin dependent protein kinase kinase 1 ISO RGD PMID:16054095 RGD:2311420 NCBI chr17:3,908,598...3,941,118
Ensembl chr17:3,900,458...3,930,010 		JBrowse link
G CAMKK2 calcium/calmodulin dependent protein kinase kinase 2 ISO RGD PMID:16054095 RGD:2311420 NCBI chr12:118,835,862...118,896,918
Ensembl chr12:122,206,552...122,267,631 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A ISO RGD PMID:30868489 RGD:25823184 NCBI chr11:63,841,028...63,928,242
Ensembl chr11:67,144,736...67,205,481 		JBrowse link
G PPM1E protein phosphatase, Mg2+/Mn2+ dependent 1E ISO RGD PMID:20801214 RGD:7794756 NCBI chr17:52,832,291...53,057,157
Ensembl chr17:57,874,629...57,903,205 		JBrowse link
G PPM1F protein phosphatase, Mg2+/Mn2+ dependent 1F ISO RGD PMID:20801214 RGD:7794756 NCBI chr22:4,039,032...4,072,165
Ensembl chr22:20,520,022...20,553,128 		JBrowse link
G PPP1CA protein phosphatase 1 catalytic subunit alpha ISO RGD PMID:21782450 RGD:7794757 NCBI chr11:62,756,659...62,760,369
Ensembl chr11:66,068,007...66,071,611 		JBrowse link
G PPP1CB protein phosphatase 1 catalytic subunit beta ISO RGD PMID:21782450 RGD:7794757 NCBI chr2A:28,758,176...28,809,561
Ensembl chr2A:28,862,083...28,889,401 		JBrowse link
G PPP1R3D protein phosphatase 1 regulatory subunit 3D ISO RGD PMID:21782450 RGD:7794757 NCBI chr20:56,292,457...56,295,977 JBrowse link
G PPP2CA protein phosphatase 2 catalytic subunit alpha ISO RGD PMID:21782450 RGD:7794757 NCBI chr 5:129,599,606...129,629,312
Ensembl chr 5:135,751,958...135,765,786 		JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 ISO RGD PMID:12829246 PMID:14511394 PMID:15509864 RGD:1600678 RGD:1600679 RGD:1600691 NCBI chr 5:69,581,748...69,620,721
Ensembl chr 5:74,627,830...74,666,505 		JBrowse link
G PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 ISO RGD PMID:12829246 PMID:14511394 PMID:15509864 RGD:1600678 RGD:1600679 RGD:1600691 NCBI chr 1:55,928,577...55,998,628
Ensembl chr 1:57,664,237...57,702,227 		JBrowse link
G PRKAB1 protein kinase AMP-activated non-catalytic subunit beta 1 ISO RGD PMID:12829246 PMID:15509864 RGD:1600678 RGD:1600679 NCBI chr12:117,246,691...117,260,465
Ensembl chr12:120,624,004...120,637,585 		JBrowse link
G PRKAB2 protein kinase AMP-activated non-catalytic subunit beta 2 ISO RGD PMID:12829246 PMID:15509864 RGD:1600678 RGD:1600679 NCBI chr 1:122,577,308...122,595,083
Ensembl chr 1:112,934,877...112,952,364 		JBrowse link
G PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 ISO RGD PMID:12829246 PMID:14511394 PMID:15509864 RGD:1600678 RGD:1600679 RGD:1600691 NCBI chr12:39,731,899...39,748,620
Ensembl chr12:40,611,532...40,628,263 		JBrowse link
G PRKAG2 protein kinase AMP-activated non-catalytic subunit gamma 2 ISO RGD PMID:12829246 PMID:15509864 RGD:1600678 RGD:1600679 NCBI chr 7:143,143,556...143,463,492
Ensembl chr 7:155,293,748...155,610,078 		JBrowse link
G PRKAG3 protein kinase AMP-activated non-catalytic subunit gamma 3 ISO RGD PMID:12829246 PMID:15509864 RGD:1600678 RGD:1600679 NCBI chr2B:106,085,299...106,139,298
Ensembl chr2B:224,679,831...224,687,705 		JBrowse link
G STK11 serine/threonine kinase 11 ISO RGD PMID:14511394 PMID:15509864 RGD:1600678 RGD:1600691 Ensembl chr19:1,188,537...1,210,677 JBrowse link
G STRADA STE20 related adaptor alpha ISO RGD PMID:14511394 PMID:15509864 RGD:1600678 RGD:1600691 NCBI chr17:57,783,114...57,822,056
Ensembl chr17:62,929,065...62,967,021 		JBrowse link
G TSC1 TSC complex subunit 1 ISO RGD PMID:31787541 RGD:25823196 NCBI chr 9:104,007,708...104,060,938
Ensembl chr 9:132,638,003...132,675,759 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4069
    signaling pathway 1942
      signaling pathway involving second messengers 267
        adenosine monophosphate-activated protein kinase (AMPK) signaling pathway 23
Path 2
Term Annotations click to browse term
  pathway 4069
    regulatory pathway 2518
      homeostasis pathway 1306
        energy homeostasis pathway 234
          adenosine monophosphate-activated protein kinase (AMPK) signaling pathway 23
paths to the root