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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:adenosine monophosphate-activated protein kinase (AMPK) signaling pathway
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Accession:PW:0000542 term browser browse the term
Definition:AMPK senses changes in cellular energy as an ATP/AMP ratio. AMP binding allosterically activates AMPK; subsequent phosphorylation events lead to repression of energy consuming pathways. One target of AMPK is the mTOR signaling pathway. AMPK activates the inhibitory Tsc2 while inhibiting the mTorc1 complex.
Synonyms:related_synonym: 5'AMP-activated protein kinase;   AMPK signaling pathway
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adenosine monophosphate-activated protein kinase (AMPK) signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cab39 calcium binding protein 39 TAS
IDA		 RGD PMID:15509864 PMID:14511394 RGD:1600678, RGD:1600691 NCBI chr 9:86,463,095...86,524,545
Ensembl chr 9:86,463,095...86,524,544 		JBrowse link
G Calm1 calmodulin 1 ISO RGD PMID:16054095 RGD:2311420 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227 		JBrowse link
G Calm2 calmodulin 2 ISO RGD PMID:16054095 RGD:2311420 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287 		JBrowse link
G Calm3 calmodulin 3 ISO RGD PMID:16054095 RGD:2311420 NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207 		JBrowse link
G Camkk1 calcium/calmodulin-dependent protein kinase kinase 1 IDA RGD PMID:16054095 RGD:2311420 NCBI chr10:57,637,335...57,660,498
Ensembl chr10:57,637,391...57,660,498 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 IDA RGD PMID:16054095 RGD:2311420 NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A IEP RGD PMID:30868489 RGD:25823184 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Ppm1e protein phosphatase, Mg2+/Mn2+ dependent, 1E ISO RGD PMID:20801214 RGD:7794756 NCBI chr10:72,051,643...72,187,439
Ensembl chr10:72,055,208...72,187,282 		JBrowse link
G Ppm1f protein phosphatase, Mg2+/Mn2+ dependent, 1F ISO RGD PMID:20801214 RGD:7794756 NCBI chr11:84,064,422...84,094,410
Ensembl chr11:84,064,420...84,094,340 		JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha ISO RGD PMID:21782450 RGD:7794757 NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327 		JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta ISO RGD PMID:21782450 RGD:7794757 NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824 		JBrowse link
G Ppp1r3d protein phosphatase 1, regulatory subunit 3D ISO RGD PMID:21782450 RGD:7794757 NCBI chr 3:165,502,384...165,505,455
Ensembl chr 3:165,502,384...165,505,455 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha ISO RGD PMID:21782450 RGD:7794757 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 ISO
IDA		 RGD PMID:15509864 PMID:14511394 PMID:12829246 RGD:1600678, RGD:1600691, RGD:1600679 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 ISO
IDA		 RGD PMID:15509864 PMID:14511394 PMID:12829246 RGD:1600678, RGD:1600691, RGD:1600679 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 ISO RGD PMID:15509864 PMID:12829246 RGD:1600678, RGD:1600679 NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661 		JBrowse link
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 ISO RGD PMID:15509864 PMID:12829246 RGD:1600678, RGD:1600679 NCBI chr 2:185,257,218...185,272,846
Ensembl chr 2:185,257,213...185,269,872 		JBrowse link
G Prkag1 protein kinase AMP-activated non-catalytic subunit gamma 1 ISO
IDA		 RGD PMID:15509864 PMID:14511394 PMID:12829246 RGD:1600678, RGD:1600691, RGD:1600679 NCBI chr 7:129,963,105...129,980,532
Ensembl chr 7:129,963,105...129,980,561 		JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 ISO RGD PMID:15509864 PMID:12829246 RGD:1600678, RGD:1600679 NCBI chr 4:10,010,890...10,252,155
Ensembl chr 4:10,010,890...10,252,142 		JBrowse link
G Prkag3 protein kinase AMP-activated non-catalytic subunit gamma 3 ISO RGD PMID:15509864 PMID:12829246 RGD:1600678, RGD:1600679 NCBI chr 9:76,295,715...76,304,959
Ensembl chr 9:76,295,715...76,304,959 		JBrowse link
G Stk11 serine/threonine kinase 11 TAS
IDA		 RGD PMID:15509864 PMID:14511394 RGD:1600678, RGD:1600691 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Strada STE20 related adaptor alpha TAS
IDA		 RGD PMID:15509864 PMID:14511394 RGD:1600678, RGD:1600691 NCBI chr10:91,094,849...91,123,890
Ensembl chr10:91,094,687...91,123,830 		JBrowse link
G Tsc1 TSC complex subunit 1 IEP RGD PMID:31787541 RGD:25823196 NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2635
      signaling pathway involving second messengers 359
        adenosine monophosphate-activated protein kinase (AMPK) signaling pathway 23
Path 2
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3867
      homeostasis pathway 1773
        energy homeostasis pathway 431
          adenosine monophosphate-activated protein kinase (AMPK) signaling pathway 23
paths to the root