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The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (

Term:angiotensin (1-7) signaling pathway
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Accession:PW:0000529 term browser browse the term
Definition:Angiotensin (1-7) is derived from angiotensin II through the action of angiotensin converting enzyme 2 (ACE2) or from angiotensin I through the action of neutral endopeptidase (NEP). Angiotensin (1-7) signaling appears to have a vasodilatory effect but the exact action of this peptide in humans remains to be established.

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angiotensin (1-7) signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 ISO RGD PMID:15638741 RGD:1581742 NCBI chrNW_004936470:4,964,526...5,011,808
Ensembl chrNW_004936470:4,965,332...5,011,702
JBrowse link
G Agt angiotensinogen ISO RGD PMID:15951342 RGD:1581938 NCBI chrNW_004936484:19,713,299...19,721,144
Ensembl chrNW_004936484:19,716,165...19,721,261
JBrowse link
G LOC101968921 angiotensin-converting enzyme ISO RGD PMID:10642323 PMID:15283675 RGD:1581953 RGD:1598433 NCBI chrNW_004936541:4,157,847...4,178,156
Ensembl chrNW_004936541:4,157,393...4,178,177
JBrowse link
G Mme membrane metalloendopeptidase ISO RGD PMID:10642323 PMID:15638741 PMID:16520407 RGD:1581742 RGD:1581931 RGD:1581953 NCBI chrNW_004936519:2,513,896...2,595,896
Ensembl chrNW_004936519:2,513,704...2,595,971
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3947
    signaling pathway 1893
      hormone signaling pathway 368
        peptide and protein hormone signaling pathway 263
          angiotensin signaling pathway 37
            angiotensin (1-7) signaling pathway 4
Path 2
Term Annotations click to browse term
  pathway 3947
    regulatory pathway 2449
      homeostasis pathway 1274
        cardiovascular system homeostasis pathway 256
          renin-angiotensin cascade pathway 41
            angiotensin signaling pathway 37
              angiotensin (1-7) signaling pathway 4
paths to the root