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The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (

Term:angiotensin (1-7) signaling pathway
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Accession:PW:0000529 term browser browse the term
Definition:Angiotensin (1-7) is derived from angiotensin II through the action of angiotensin converting enzyme 2 (ACE2) or from angiotensin I through the action of neutral endopeptidase (NEP). Angiotensin (1-7) signaling appears to have a vasodilatory effect but the exact action of this peptide in humans remains to be established.

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angiotensin (1-7) signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ISO RGD PMID:10642323 PMID:15283675 RGD:1581953 RGD:1598433 NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703
JBrowse link
G ACE2 angiotensin converting enzyme 2 ISO RGD PMID:15638741 RGD:1581742 NCBI chr  X:12,099,849...12,152,204
Ensembl chr  X:12,093,242...12,151,286
JBrowse link
G AGT angiotensinogen ISO RGD PMID:15951342 RGD:1581938 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833
JBrowse link
G MAS1 MAS1 proto-oncogene, G protein-coupled receptor ISO RGD PMID:15951342 PMID:16520407 RGD:1581931 RGD:1581938 NCBI chr 1:7,527,566...7,542,110
Ensembl chr 1:7,527,861...7,528,838
JBrowse link
G MME membrane metalloendopeptidase ISO RGD PMID:10642323 PMID:15638741 PMID:16520407 RGD:1581742 RGD:1581931 RGD:1581953 NCBI chr13:95,018,395...95,122,977
Ensembl chr13:95,019,081...95,126,045
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4039
    signaling pathway 1924
      hormone signaling pathway 378
        peptide and protein hormone signaling pathway 272
          angiotensin signaling pathway 39
            angiotensin (1-7) signaling pathway 5
Path 2
Term Annotations click to browse term
  pathway 4039
    regulatory pathway 2496
      homeostasis pathway 1298
        cardiovascular system homeostasis pathway 262
          renin-angiotensin cascade pathway 43
            angiotensin signaling pathway 39
              angiotensin (1-7) signaling pathway 5
paths to the root