angiotensin (1-7) signaling pathway - Ontology Report - Rat Genome Database

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PATHWAY ONTOLOGY - ANNOTATIONS	{{ watchLinkText }}
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:	angiotensin (1-7) signaling pathway	go back to main search page
Accession:	PW:0000529	browse the term
Definition:	Angiotensin (1-7) is derived from angiotensin II through the action of angiotensin converting enzyme 2 (ACE2) or from angiotensin I through the action of neutral endopeptidase (NEP). Angiotensin (1-7) signaling appears to have a vasodilatory effect but the exact action of this peptide in humans remains to be established.

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Genes (5)

angiotensin (1-7) signaling pathway

term browser

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

PMID:10642323 PMID:15283675

RGD:1581953 RGD:1598433

NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703

G

angiotensin converting enzyme 2

NCBI chr X:12,099,849...12,152,204
Ensembl chr X:12,093,242...12,151,286

G

angiotensinogen

NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833

G

MAS1 proto-oncogene, G protein-coupled receptor

PMID:15951342 PMID:16520407

RGD:1581931 RGD:1581938

NCBI chr 1:7,527,566...7,542,110
Ensembl chr 1:7,527,861...7,528,838

G

membrane metalloendopeptidase

PMID:10642323 PMID:15638741 PMID:16520407

RGD:1581742 RGD:1581931 RGD:1581953

NCBI chr13:95,018,395...95,122,977
Ensembl chr13:95,019,081...95,126,045

Term paths to the root

Path 1
Term	Annotations
pathway	4039
signaling pathway	1924
hormone signaling pathway	378
peptide and protein hormone signaling pathway	272
angiotensin signaling pathway	39
angiotensin (1-7) signaling pathway	5
Path 2
Term	Annotations
pathway	4039
regulatory pathway	2496
homeostasis pathway	1298
cardiovascular system homeostasis pathway	262
renin-angiotensin cascade pathway	43
angiotensin signaling pathway	39
angiotensin (1-7) signaling pathway	5

paths to the root