kallikrein-kinin cascade pathway - Ontology Report - Rat Genome Database

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PATHWAY ONTOLOGY - ANNOTATIONS	{{ watchLinkText }}
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:	kallikrein-kinin cascade pathway	go back to main search page
Accession:	PW:0000526	browse the term
Definition:	The kallikrein-kinin system (KKS) cascade generates several bioactive kinins with roles in vasodilation, release of inflammatory mediators and stimulation of sensory neurons. Kinins also play a role in the renal handling of sodium and water metabolism. In the latter case, the system parallels renin-angiotensin (RAS); the two systems can cross-talk.
Synonyms:	related_synonym:	KKS system signaling pathway; tissue kallikrein-kinin cascade

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Genes (19)

kallikrein-kinin cascade pathway

term browser

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

RGD

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

angiotensin I converting enzyme

RGD

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

bradykinin receptor B1

RGD

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

bradykinin receptor B2

RGD

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

carboxypeptidase M

RGD

NCBI chr 7:53,225,647...53,286,220
Ensembl chr 7:53,225,696...53,286,220

G

carboxypeptidase N subunit 1

RGD

NCBI chr 1:242,844,575...242,873,465
Ensembl chr 1:242,844,212...242,873,465

G

coagulation factor XII

RGD

NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530

G

kallikrein 1

RGD

NCBI chr 1:94,642,722...94,646,714
Ensembl chr 1:94,642,687...94,646,754

G

kallikrein B1

RGD

PMID:18396440 PMID:16177542

RGD:7401224, RGD:7401223

NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053

G

kininogen 2

RGD

NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971

G

membrane metallo-endopeptidase

NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792

G

prolylcarboxypeptidase

RGD

NCBI chr 1:146,931,487...146,983,891
Ensembl chr 1:146,930,561...146,984,530

G

serpin family A member 4

RGD

NCBI chr 6:122,999,970...123,009,083
Ensembl chr 6:122,999,900...123,009,082

G

serpin family G member 1

RGD

NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034

G

X-prolyl aminopeptidase 1

RGD

NCBI chr 1:252,001,366...252,052,077
Ensembl chr 1:252,001,367...252,051,479

G

X-prolyl aminopeptidase 2

RGD

NCBI chr X:127,287,765...127,317,036
Ensembl chr X:127,287,979...127,317,223

kinin signaling pathway

term browser

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arrestin, beta 1

RGD

NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061

G

arrestin, beta 2

RGD

NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850

G

bradykinin receptor B1

RGD

PMID:16177542 PMID:15734727

RGD:7401223, RGD:7401225

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

bradykinin receptor B2

RGD

PMID:16177542 PMID:15734727

RGD:7401223, RGD:7401225

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

G protein-coupled receptor kinase 4

RGD

NCBI chr14:75,998,554...76,080,808
Ensembl chr14:76,006,218...76,080,693

G

kininogen 2

RGD

NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971

Term paths to the root

Path 1
Term	Annotations
pathway	6100
signaling pathway	2646
signaling pathway pertinent to immunity	794
kallikrein-kinin cascade pathway	19
kinin signaling pathway	6
Path 2
Term	Annotations
pathway	6100
signaling pathway	2646
signaling pathway pertinent to the brain and nervous system	464
sensory system signaling pathway	78
kallikrein-kinin cascade pathway	19
kinin signaling pathway	6

paths to the root