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Term:interleukin-6 signaling pathway
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Accession:PW:0000516 term browser browse the term
Definition:Interleukin-6 signaling is involved in a wide range of biological processes such as immune regulation, inflammation, hematopoiesis and oncogenesis. A signal transducer common to all family members, gp130 activates Jak-Stat and Raf/Mek/Erk signaling pathways.
Synonyms:exact_synonym: Reactome:R-HSA-1059683
 related_synonym: Il-6 signaling pathway;   PID:200146

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interleukin-6 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2m alpha-2-macroglobulin JBrowse link NW_004936870 424,832 468,303 RGD:9068941
G Adam10 ADAM metallopeptidase domain 10 JBrowse link NW_004936471 19,760,709 19,911,759 RGD:9068941
G Adam17 ADAM metallopeptidase domain 17 JBrowse link NW_004936532 5,864,851 5,904,005 RGD:9068941
G Akt1 AKT serine/threonine kinase 1 JBrowse link NW_004936621 620,163 639,115 RGD:9068941
G Cebpd CCAAT enhancer binding protein delta JBrowse link NW_004936590 4,919,862 4,920,612 RGD:9068941
G Crp C-reactive protein JBrowse link NW_004936740 885,855 888,854 RGD:9068941
G Fgg fibrinogen gamma chain JBrowse link NW_004936576 1,343,657 1,352,085 RGD:9068941
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link NW_004936488 4,384,710 4,388,118 RGD:9068941
G Foxo1 forkhead box O1 JBrowse link NW_004936565 5,210,014 5,299,213 RGD:9068941
G Gab1 GRB2 associated binding protein 1 JBrowse link NW_004936535 4,934,743 5,048,698 RGD:9068941
G Gab2 GRB2 associated binding protein 2 JBrowse link NW_004936498 6,775,170 6,835,680 RGD:9068941
G Grb2 growth factor receptor bound protein 2 JBrowse link NW_004936594 592,760 661,369 RGD:9068941
G Hck HCK proto-oncogene, Src family tyrosine kinase JBrowse link NW_004936485 18,996,016 19,017,908 RGD:9068941
G Hsp90b1 heat shock protein 90 beta family member 1 JBrowse link NW_004936492 10,513,908 10,528,281 RGD:9068941
G Il6r interleukin 6 receptor JBrowse link NW_004936580 4,055,438 4,081,876 RGD:9068941
G Il6st interleukin 6 signal transducer JBrowse link NW_004936480 11,867,573 11,913,563 RGD:9068941
G Irf1 interferon regulatory factor 1 JBrowse link NW_004936647 2,686,247 2,693,633 RGD:9068941
G Jak1 Janus kinase 1 JBrowse link NW_004936692 2,298,149 2,354,084 RGD:9068941
G Jak2 Janus kinase 2 JBrowse link NW_004936503 111,722 243,627 RGD:9068941
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link NW_004936522 3,034,364 3,037,632 RGD:9068941
G Junb JunB proto-oncogene, AP-1 transcription factor subunit JBrowse link NW_004936659 1,890,786 1,892,619 RGD:9068941
G Lbp lipopolysaccharide binding protein JBrowse link NW_004936561 3,017,471 3,035,481 RGD:9068941
G Lmo4 LIM domain only 4 JBrowse link NW_004936732 1,541,511 1,557,845 RGD:9068941
G Map2k4 mitogen-activated protein kinase kinase 4 JBrowse link NW_004936595 4,762,327 4,828,433 RGD:9068941
G Mapk11 mitogen-activated protein kinase 11 JBrowse link NW_004936629 542,143 549,861 RGD:9068941
G Mapk14 mitogen-activated protein kinase 14 JBrowse link NW_004936476 23,237,762 23,310,211 RGD:9068941
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link NW_004936580 803,452 806,966 RGD:9068941
G Mitf melanocyte inducing transcription factor JBrowse link NW_004936603 1,682,411 1,858,295 RGD:9068941
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link NW_004936470 20,480,844 20,485,955 RGD:9068941
G Pias1 protein inhibitor of activated STAT 1 JBrowse link NW_004936471 27,925,153 28,055,632 RGD:9068941
G Pias3 protein inhibitor of activated STAT 3 JBrowse link NW_004936867 603,007 612,488 RGD:9068941
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link NW_004936566 3,924,013 3,951,052 RGD:9068941
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link NW_004936480 1,188,408 1,273,210 RGD:9068941
G Prkcd protein kinase C delta JBrowse link NW_004936473 3,892,625 3,923,467 RGD:9068941
G Ptpn11 protein tyrosine phosphatase non-receptor type 11 JBrowse link NW_004936668 2,602,261 2,687,903 RGD:9068941
G Rac1 Rac family small GTPase 1 JBrowse link NW_004936750 107,689 122,679 RGD:9068941
G Socs3 suppressor of cytokine signaling 3 JBrowse link NW_004936594 2,932,297 2,935,358 RGD:9068941
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link NW_004936508 12,162,553 12,281,812 RGD:9068941
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link NW_004936495 15,286,524 15,365,598 RGD:9068941
G Stat1 signal transducer and activator of transcription 1 JBrowse link NW_004936506 7,196,860 7,235,854 RGD:9068941
G Stat3 signal transducer and activator of transcription 3 JBrowse link NW_004936490 17,119,189 17,178,402 RGD:9068941
G Timp1 TIMP metallopeptidase inhibitor 1 JBrowse link NW_004936502 13,345,936 13,350,170 RGD:9068941
G Tnfsf11 TNF superfamily member 11 JBrowse link NW_004936747 1,255,803 1,288,252 RGD:9068941
G Tyk2 tyrosine kinase 2 JBrowse link NW_004936659 681,463 704,484 RGD:9068941
G Vav1 vav guanine nucleotide exchange factor 1 JBrowse link NW_004936588 4,058,312 4,107,330 RGD:9068941

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  pathway 5482
    signaling pathway 2378
      cytokine and chemokine mediated signaling pathway 321
        cytokine mediated signaling pathway 320
          Interleukin mediated signaling pathway 234
            interleukin-6 family mediated signaling pathway 45
              interleukin-6 signaling pathway 45
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.